Drug General Information (ID: DDIIYTZLCQ)
Drug Name			Bexarotene		Drug Info		Gemfibrozil		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antihyperammonia Agents
Structure

Mechanism of Bexarotene-Gemfibrozil Interaction (Severity Level: Major)
Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Bexarotene				Gemfibrozil
Mechanism		Bexarotene				Increase the plasma concentrations of bexarotene
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Bexarotene caused by Gemfibrozil

Recommended Action
Management		The use of bexarotene in combination with gemfibrozil should generally be avoided.

References
1	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
2	Talpur R, Ward S, Apisarnthanarax N, Breuer-Mcham J, Duvic M "Optimizing bexarotene therapy for cutaneous T-cell lymphoma." J Am Acad Dermatol 47 (2002): 672-84.[PMID: 12399758]
3	Wiggins BS, Saseen JJ, Morris PB. "Gemfibrozil in Combination with Statins-Is It Really Contraindicated?."?Curr Atheroscler Rep. 2016;18(4):18.[PMID: 26932225]