Details of Drug

Drug General Information (ID: D0178)
Drug Name	Bexarotene
Drug Type	Small molecule
Drug Synonymous	Bexaroteno; Bexarotenum; Targret; Targretin; Targretyn; Targrexin; Bexarotene [USAN]; Elan brand of bexarotene;Ligand brand of bexarotene; LG 1069; LG100069; LG1069; LG69 compound; LGD 1069; LGD1069; LG-100069; LGD-1069; Targretin (TN); Targretin-gel; Bexarotene (USAN/INN); P-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid; 3-methyl-TTNEB; 4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl)benzoic acid; 4-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic acid; 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid; 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid; 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid; 4-[1-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthaleneyl)vinyl]benzene carboxylic acid; 9RA Click to Show/Hide
Disease Class	2B01: Mycosis fungoides
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C24H28O2
InChI	1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
InChIKey	NAVMQTYZDKMPEU-UHFFFAOYSA-N
Canonical SMILES	CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C
External Link
	Pubchem ID	82146
	CAS Number	153559-49-0
	CHEBI ID	50859
	TTD ID	D0N0RU
	INTEDE ID	DR0208

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM025 Decreased metabolism (Unspecific) BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM072 Increased risk of nephrotoxicity BM075 Increased risk of photosensitivity reactions BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Bexarotene
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[50]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[154]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[333]
	CYP450 enzyme induction					Drug Num: 263
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0485		Dienogest	C20H25NO2	68861	Major		Inter Info	[20], [8], [21]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[22], [8]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[20], [8], [21]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[27], [28]
D0922		Levonorgestrel	C21H28O2	13109	Major		Inter Info	[22], [8]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[30]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Major		Inter Info	[20], [8], [21]
D1011		Mestranol	C21H26O2	6291	Major		Inter Info	[20], [8], [21]
D1154		Norethisterone	C20H26O2	6230	Major		Inter Info	[20], [8], [21]
D1156		Norgestimate	C23H31NO3	6540478	Major		Inter Info	[20], [8], [21]
D1157		Norgestrel	C21H28O2	13109	Major		Inter Info	[22], [8]
D0450		Desogestrel	C22H30O	40973	Major		Inter Info	[20], [8], [21]
D0626		Etonogestrel	C22H28O2	6917715	Major		Inter Info	[22], [8]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[43]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[51]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[52]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[7], [8], [55]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[56], [57], [58], [59]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[60]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[7], [8], [55]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[7], [8], [55]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[81]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[82]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[83]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[84], [85]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[7], [8], [55]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[86], [87], [88], [89], [90]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[91]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[7], [92]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[93], [94]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[7], [8], [55]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[7], [8], [55]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[7], [96], [97]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[101], [102]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[103]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[105]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[106], [107], [108]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[109], [110], [111], [14], [7], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[126]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[127], [128]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[130]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[7], [131]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[132]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[7], [8], [55]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[7], [8], [55]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[7], [8], [55]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[134]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[138]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[139], [7], [140]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[141]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[14], [7], [142]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[143], [144]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[7], [8], [55]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[14], [7], [146]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[147], [148], [149], [150], [21]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[7], [8], [55]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[152]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[153], [154]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[7], [155], [156], [157]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[155], [156], [157]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[158]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[7], [8], [55]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[14], [159]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[65], [7], [160], [150], [8], [161]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[162]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[163]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[164]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[165]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[166]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[14], [7], [146]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[14], [7], [146]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[168], [169]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[7], [8], [55]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [147], [178], [179], [180], [181], [182], [183], [184], [185], [22], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [21], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [147], [178], [179], [180], [181], [182], [183], [184], [185], [22], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [21], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[174], [183], [206]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [147], [178], [179], [180], [181], [182], [183], [184], [185], [22], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [21], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[174], [183], [206]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[214]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[7], [8], [55]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[7], [8], [55]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[14], [7], [215]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[216]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[7], [8], [55]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[7], [8], [55]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[109], [110], [111], [14], [7], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[217]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[218]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[7], [8], [55]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[219]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[168], [222]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[223]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[224]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[7], [8], [55]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[225]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[7], [226], [227]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[7], [8], [55]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[109], [110], [111], [14], [7], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[7], [8], [55]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[228]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[231], [232], [237]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[245]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[7], [246]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[247], [248], [249], [250]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[251]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[252]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[14], [7], [253]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[14], [7], [254]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[255]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[14], [256]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[7], [8], [55]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[7], [8], [55]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[257]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[14], [7], [258]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[259]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[260]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[261], [262]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[14], [263]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[264]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[174], [183], [206]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[109], [110], [111], [14], [7], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[14], [7], [146]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[7], [8], [55]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[7], [8], [55]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[269], [270]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[84], [85]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[271]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[7], [8], [55]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[272]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[7], [8], [55]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[7], [8], [55]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[7], [8], [55]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[7], [8], [55]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[7], [8], [55]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[109], [110], [111], [14], [7], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[278]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[279]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[7], [8], [55]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[109], [110], [111], [14], [7], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[280], [281], [282], [283]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[280], [281], [282]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[14], [7], [284]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[285]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[286]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[7], [291]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[7], [292]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[300]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[303], [14], [304], [305]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[7], [8], [55]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[7], [8], [55]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [147], [178], [179], [180], [181], [182], [183], [184], [185], [22], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [21], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[174], [183], [206]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [147], [178], [179], [180], [181], [182], [183], [184], [185], [22], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [21], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[7], [8], [55]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[7], [8], [55]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[307]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[311], [312], [313]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[14], [7], [314]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[14], [139], [7], [315]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[316]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[14], [317]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[318]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[320]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[321]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[7], [322]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[323]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[14], [7], [324]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[7], [8], [55]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[14], [7], [325], [326]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[328]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[329]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[330]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[331], [332]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[7], [8], [55]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[334]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[14], [7], [325], [326]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[7], [335], [336]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[337], [338], [339], [8]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[340]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[341]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[101], [102]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[342], [343]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[7], [344]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[14], [7], [345]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[7], [8], [55]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[65], [7], [346], [347], [348]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[7], [8], [55]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[7], [351]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[353], [14], [7], [338], [354]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[7], [8], [55]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[7], [8], [55]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[7], [8], [55]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[356]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[7], [357]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[359]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[360]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[362]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[7], [8], [55]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[7], [8], [55]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[7], [8], [55]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[7], [8], [55]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[363]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[364]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[7], [365], [366], [367]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[368], [369]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[170], [171], [172], [173], [174], [175], [176], [177], [147], [178], [179], [180], [181], [182], [183], [184], [185], [22], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [21], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[7], [8], [55]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[7], [8], [55]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[7], [8], [55]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[14], [7], [146]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[377], [378], [379], [380]
D0061		Aminoglutethimide	C13H16N2O2	2145	Minor		Inter Info	[8]
D0071		Amobarbital	C11H18N2O3	2164	Minor		Inter Info	[8]
D0194		Bosentan	C27H29N5O6S	104865	Minor		Inter Info	[8]
D0255		Carbamazepine	C15H12N2O	2554	Minor		Inter Info	[8]
D0300		Cenobamate	C10H10ClN5O2	11962412	Minor		Inter Info	[8]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Minor		Inter Info	[8]
D0432		Deferasirox	C21H15N3O4	214348	Minor		Inter Info	[8]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[381]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Minor		Inter Info	[8]
D0628		Etravirine	C20H15BrN6O	193962	Minor		Inter Info	[8]
D0639		Felbamate	C11H14N2O4	3331	Minor		Inter Info	[8]
D0697		Fosphenytoin	C16H15N2O6P	56339	Minor		Inter Info	[8]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[382]
D0741		Griseofulvin	C17H17ClO6	441140	Minor		Inter Info	[8]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Minor		Inter Info	[8]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[383]
D0953		Lorlatinib	C21H19FN6O2	71731823	Minor		Inter Info	[8]
D1040		Methylphenobarbital	C13H14N2O3	8271	Minor		Inter Info	[384], [8], [385]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[386]
D1078		Mitotane	C14H10Cl4	4211	Minor		Inter Info	[8]
D1099		Nafcillin	C21H22N2O5S	8982	Minor		Inter Info	[8]
D1198		Oxcarbazepine	C15H12N2O2	34312	Minor		Inter Info	[8]
D1248		Pentobarbital	C11H18N2O3	4737	Minor		Inter Info	[8]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[8]
D1274		Phenylbutazone	C19H20N2O2	4781	Minor		Inter Info	[8]
D1340		Primidone	C12H14N2O2	4909	Minor		Inter Info	[8]
D1399		Rifabutin	C46H62N4O11	135398743	Minor		Inter Info	[8]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[384], [8], [385]
D1401		Rifapentine	C47H64N4O12	135403821	Minor		Inter Info	[8]
D1433		Rufinamide	C10H8F2N4O	129228	Minor		Inter Info	[8]
D1453		Secobarbital	C12H18N2O3	5193	Minor		Inter Info	[8]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Minor		Inter Info	[8]
D1716		Zaleplon	C17H15N5O	5719	Minor		Inter Info	[387]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[7], [388], [389], [390], [391]
D0224		Butabarbital	C10H16N2O3	2479	Minor		Inter Info	[8]
D0225		Butalbital	C11H16N2O3	2481	Minor		Inter Info	[8]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[392]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[393], [247], [250]
D0513		Dofetilide	C19H27N3O5S2	71329	Minor		Inter Info	[394]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[395], [396], [397], [398]
D1128		Nevirapine	C15H14N4O	4463	Minor		Inter Info	[8]
D1652		Troglitazone	C24H27NO5S	5591	Minor		Inter Info	[8]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[399], [400]
	Decreased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[8], [24], [25]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[14], [7], [15]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[23]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [32]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[14], [35]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[39]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[40]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [41]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[42]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[36], [44], [45]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[46]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[47], [48], [49]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[14], [7]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[47], [48], [49]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[145]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[151]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[151]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[151]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[274]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[275]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [276]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[277]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[306]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[47], [48], [49]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [319]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[327]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[14], [7], [266]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[352]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[358]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[370]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[375]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[7], [16], [17]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[14], [18], [19]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[34]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[14], [7], [220], [221]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[14], [7], [220], [221]
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[26]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[29]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[31]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[33]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[26]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[95]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[104]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[7], [129]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[133]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[14], [7], [167]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[229]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[7], [265]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[273]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[287], [288], [289], [290]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[14], [7], [308], [309], [310]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[349], [350]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[7], [355]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[287], [288], [289], [290]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[287], [288], [289], [290]
	Increased risk of hypoglycemia					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[7], [53], [54]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[7], [53], [54]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[7], [53], [54]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[7], [53], [54]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[7], [53], [54]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[7], [53], [54]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[7], [53], [54]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[7], [53], [54]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[7], [53], [54]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[7], [53], [54]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[7], [53], [54]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[7], [53], [54]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[7], [53], [54]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[7], [53], [54]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[7], [53], [54]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [53], [54]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [53], [54]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [53], [54]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [53], [54]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [53], [54]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[7], [53], [54]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[7], [53], [54]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[7], [53], [54]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[9], [10]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[14], [7], [61]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[14], [266], [9], [267], [268]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[14], [7], [61]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[301], [7], [302]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[7], [266], [9], [361]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 56
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0114		Asparaginase Escherichia coli	NA	NA	Major		Inter Info	[7], [8]
D0018		Acitretin	C21H26O3	5284513	Major		Inter Info	[7], [8]
D0029		Albiglutide	C148H224N40O45	145994868	Major		Inter Info	[7], [8]
D0042		Alogliptin	C18H21N5O2	11450633	Major		Inter Info	[7], [8]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Major		Inter Info	[7], [8]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[7], [8]
D0232		Calaspargase pegol	NA	NA	Major		Inter Info	[7], [8]
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[7], [8]
D1764		Clomifene	C26H28ClNO	1548953	Major		Inter Info	[7], [8]
D0381		Colesevelam	C31H67Cl3N4O	160051	Major		Inter Info	[7], [8]
D0404		Cytarabine	C9H13N3O5	6253	Major		Inter Info	[7], [8]
D0483		Didanosine	C10H12N4O3	135398739	Major		Inter Info	[7], [8]
D1779		Dulaglutide	NA	NA	Major		Inter Info	[7], [8]
D0562		Eluxadoline	C32H35N5O5	11250029	Major		Inter Info	[7], [8]
D0589		Eravacycline	C27H31FN4O8	54726192	Major		Inter Info	[7], [8]
D1784		Exenatide	C184H282N50O60S	45588096	Major		Inter Info	[7], [8]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[7], [8]
D0863		Isotretinoin	C20H28O2	5282379	Major		Inter Info	[7], [8]
D0889		Lamivudine	C8H11N3O3S	60825	Major		Inter Info	[7], [8]
D0930		Linagliptin	C25H28N8O2	10096344	Major		Inter Info	[7], [8]
D0936		Liraglutide	C172H265N43O51	16134956	Major		Inter Info	[7], [8]
D0941		Lixisenatide	C215H347N61O65S	90472060	Major		Inter Info	[7], [8]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[7], [8]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[7], [8]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[7], [8]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[7], [8]
D1376		Raloxifene	C28H27NO4S	5035	Major		Inter Info	[7], [8]
D1397		Ribavirin	C8H12N4O5	37542	Major		Inter Info	[7], [8]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[7], [8]
D1449		Saxagliptin	C18H25N3O2	11243969	Major		Inter Info	[7], [8]
D1887		Semaglutide	C187H291N45O59	56843331	Major		Inter Info	[7], [8]
D1477		Sitagliptin	C16H15F6N5O	4369359	Major		Inter Info	[7], [8]
D1493		Somapacitan	C54H95N13O20S2	129894493	Major		Inter Info	[7], [8]
D1495		Somatrem	C43H72N14O14	5487805	Major		Inter Info	[7], [8]
D1504		Stavudine	C10H12N2O4	18283	Major		Inter Info	[7], [8]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[7], [8]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[7], [8]
D1540		Teduglutide	C164H252N44O55S	16139605	Major		Inter Info	[7], [8]
D1582		Tigecycline	C29H39N5O8	54686904	Major		Inter Info	[7], [8]
D1626		Tretinoin	C20H28O2	444795	Major		Inter Info	[7], [8]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Major		Inter Info	[7], [8]
D1677		Valproic acid	C8H16O2	3121	Major		Inter Info	[7], [8]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[7], [8]
D1715		Zalcitabine	C9H13N3O3	24066	Major		Inter Info	[7], [8]
D1720		Zidovudine	C10H13N5O4	35370	Major		Inter Info	[7], [8]
D0487		Diethylstilbestrol	C18H20O2	448537	Major		Inter Info	[7], [8]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[7], [8]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[7], [8]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[7], [8]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[7], [8]
D0828		Interferon gamma-1b	NA	NA	Major		Inter Info	[7], [8]
D1163		Octreotide	C49H66N10O10S2	448601	Major		Inter Info	[7], [8]
D1234		Pegaspargase	C14H19NO	436058	Major		Inter Info	[7], [8]
D1237		Peginterferon alfa-2a	NA	NA	Major		Inter Info	[7], [8]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[7], [8]
D1494		Somatotropin	NA	NA	Major		Inter Info	[7], [8]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[11], [12], [13]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[11], [12], [13]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[11], [12], [13]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[11], [12], [13]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[11], [12], [13]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[36], [14], [37]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[38]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[11], [12], [13]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[11], [12], [13]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[11], [12], [13]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[36], [79], [80]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[36], [79], [80]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[36], [79], [80]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[36], [79], [80]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[36], [79], [80]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[36], [79], [80]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[36], [79], [80]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[36], [79], [80]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[293], [36], [14], [294], [295], [296], [79], [297], [298], [299], [80]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[36], [79], [80]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[36], [79], [80]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[36], [79], [80]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[374]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[98], [99], [100]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[98], [99], [100]
	Diminish the response to diagnostic skin test antigens					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[135], [136], [137]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[135], [136], [137]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[135], [136], [137]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[371], [372], [373]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[364], [376]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[371], [372], [373]

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121	Product Information. Ionsys (fentanyl). Ortho McNeil Pharmaceutical, Raritan, NJ.
122	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
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127	Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
128	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
129	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
130	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
131	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
132	Product Information. Cancidas (caspofungin) Merck & Co, Inc, West Point, PA.
133	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
134	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
135	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
136	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
137	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
138	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
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140	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
141	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
142	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
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144	Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
145	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
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150	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
151	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
152	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
153	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
154	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
155	Product Information. Adriamycin PFS (doxorubicin). Pharmacia and Upjohn, Kalamazoo, MI.
156	Product Information. Doxil (doxorubicin liposomal). Sequis Pharmaceuticals Inc, Menlo Park, CA.
157	Kaytser V, Zhang P. Non-interacting, Non-opioid, and Non-barbiturate Containing Acute Medication Combinations in Headache: A Pilot Combinatorics Approach Based on DrugBank Database.?Front Neurol. 2021;12:632830. [PMID: 33679591]
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161	Product Information. Vesanoid (tretinoin). Roche Laboratories, Nutley, NJ.
162	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
163	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
164	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
165	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
166	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
167	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
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214	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
215	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
216	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
217	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
218	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
219	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
220	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
221	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
222	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
223	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
224	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
225	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
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227	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
228	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
229	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
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239	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
240	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
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245	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
246	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
247	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
248	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
249	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
250	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
251	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
252	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
253	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
254	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
255	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
256	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
257	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
258	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
259	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
260	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
261	Bruderer S, Aanismaa P, Homery MC, et al. "Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist." AAPS J 14 (2012): 68-78. [PMID: 22189899]
262	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
263	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
264	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
265	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
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267	Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
268	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
269	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
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271	Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
272	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
273	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
274	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
275	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
276	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
277	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
278	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
279	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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281	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
282	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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284	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
285	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
286	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
287	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
288	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
289	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
290	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
291	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
292	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
293	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
294	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
295	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
296	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
297	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
298	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
299	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
300	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
301	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
302	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
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304	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
305	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
306	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
307	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
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309	Gilead Sciences, Inc "About Remdesivir.".
310	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
311	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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313	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
314	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
315	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
316	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
317	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
318	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
319	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
320	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
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357	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
358	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
359	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
360	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
361	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
362	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
363	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
364	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
365	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
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372	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
373	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
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393	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
394	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
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