Drug General Information (ID: DDI7BRHNJ9)
Drug Name			Simvastatin		Drug Info		Gemfibrozil		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Statins/Antihyperlipidemic Agents				Antihyperammonia Agents
Structure

Mechanism of Simvastatin-Gemfibrozil Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Simvastatin				Gemfibrozil
Mechanism		Rhabdomyolysis				Rhabdomyolysis
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Simvastatin and Gemfibrozil

Recommended Action
Management		Concomitant use of simvastatin and gemfibrozil is considered contraindicated by the manufacturer of simvastatin.

References
1	Duell PB, Connor WE, Illingworth DR "Rhabdomyolysis after taking atorvastatin with gemfibrozil." Am J Cardiol 81 (1998): 368-9.[PMID: 9468088]
2	Mastroianni CM, dEttorre G, Forcina G, Lichtner M, Corpolongo A, Coletta S, Vullo V "Rhabdomyolysis after cerivastatin-gemfibrozil therapy in an HIV-infected patient with protease inhibitor-related hyperlipidemia." AIDS 15 (2001): 820-1.[PMID: 11371708]
3	Bermingham RP, Whitsitt TB, Smart ML, Nowak DP, Scalley RD "Rhabdomyolysis in a patient receiving the combination of cerivastatin and gemfibrozil." Am J Health Syst Pharm 57 (2000): 461-4.[PMID: 10711527]