Details of Drug

Drug General Information (ID: D1473)
Drug Name	Simvastatin
Drug Type	Small molecule
Drug Synonymous	Cholestat; Coledis; Colemin; Corolin; Denan; Labistatin; Lipex; Lipovas; Lodales; Medipo; Nivelipol; Pantok; Rendapid; Simovil; Simvastatina; Simvastatine; Simvastatinum; Sinvacor; Sivastin; Synvinolin; Vasotenal; Zocor; Zocord; Simvast CR; Simvastatina [Spanish]; Simvastatine [French]; Simvastatinum [Latin]; MK 0733; MK 733; MK733; TNP00259; DRG-0320; KS-1113; L 644128-000U; MK-0733; MK-733; Simcard (TN); Simlup (TN); Simvacor (TN); Simvastatin & Primycin; Simvastatin, Compactin; Zocor (TN); Simvastatin [USAN:INN:BAN]; Simvastatin (JAN/USP/INN); Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin; [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate; Butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S,4S*),-8a beta; 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one Click to Show/Hide
Disease Class	5C80: Hyper-lipoproteinaemia
Therapeutic Class	Statins/Antihyperlipidemic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C25H38O5
InChI	1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
InChIKey	RYMZZMVNJRMUDD-HGQWONQESA-N
Canonical SMILES	CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
External Link
	Pubchem ID	54454
	CAS Number	79902-63-9
	CHEBI ID	9150
	TTD ID	D0H0ND
	INTEDE ID	DR1485
	VARIDT ID	DR00435

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM001 Altered gastrointestinal dynamics BM003 Complex formation BM009 Altered absorption (Unspecific) BM010 Transporter inhibition BM011 Transporter induction BM012 Competitive inhibition of transporters BM013 Competitive binding of plasma proteins BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM024 Competitive inhibition of metabolic enzyme BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy BM075 Increased risk of photosensitivity reactions BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Simvastatin
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[183], [184]
D0029		Albiglutide	C148H224N40O45	145994868	Minor		Inter Info	[229], [285]
	Complex formation					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[188]
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[188]
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1233		Pectin	C6H10O7	441476	Moderate		Inter Info	[115]
Affected cellular transport
	Transporter inhibition					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0155		Bempedoic acid	C19H36O5	10472693	Major		Inter Info	[9], [95], [96]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[8], [9], [116]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[9], [200], [201]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[8], [9], [209]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[9], [215], [115]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[9], [216]
D0558		Elexacaftor	C26H34F3N7O4S	134587348	Moderate		Inter Info	[220], [200], [221]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[222], [8], [223]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[8], [224]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[233]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[239]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[9]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[8], [9]
D1436		Sacubitril	C24H29NO5	9811834	Moderate		Inter Info	[117], [9], [115]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[263]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[9], [271], [115]
	Transporter induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[9], [202]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Minor		Inter Info	[282], [283], [284]
D0087		Anisindione	C16H12O3	2197	Minor		Inter Info	[282], [283], [284], [286], [287], [1], [288], [289]
D1711		Warfarin	C19H16O4	54678486	Minor		Inter Info	[282], [283], [284], [286], [287], [1], [288], [289]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[141], [143], [148]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[9], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
	CYP450 enzyme inhibition					Drug Num: 80
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [1], [27], [28], [29], [30], [31]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[32], [33], [34]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[35], [36], [37], [10], [38], [39], [11], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [21], [57], [58], [59], [23], [60], [25], [1], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[70], [42], [45], [47], [51], [52], [54], [56], [71], [21], [57], [58], [65], [67]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[72], [9], [36], [39], [40], [44], [73], [74], [21], [60], [75], [76], [77], [78], [79], [80], [81], [82], [61]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[72], [9], [36], [39], [40], [44], [73], [74], [21], [60], [75], [76], [77], [78], [79], [80], [81], [82], [61]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[9], [15], [88], [21], [89], [1], [27], [90], [91], [92]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[72], [36], [39], [40], [44], [73], [74], [21], [60], [75], [76], [77], [78], [79], [80], [81], [82], [61]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[37], [93], [21], [25], [1], [94], [61], [91]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[72], [9], [36], [39], [40], [44], [73], [74], [21], [60], [75], [76], [77], [78], [79], [80], [81], [82], [61]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[72], [36], [39], [40], [44], [73], [74], [21], [60], [75], [76], [77], [78], [79], [80], [81], [82], [61]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[35], [36], [37], [10], [38], [39], [11], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [21], [57], [58], [59], [23], [60], [97], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[98], [99], [35], [100], [36], [37], [10], [38], [39], [11], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [21], [57], [58], [59], [23], [60], [101], [25], [1], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[35], [36], [37], [10], [38], [39], [11], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [21], [57], [58], [59], [23], [60], [25], [1], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[98], [99], [35], [100], [36], [37], [10], [38], [39], [11], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [21], [57], [58], [59], [23], [60], [101], [25], [1], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[35], [36], [37], [10], [38], [39], [11], [40], [41], [13], [43], [44], [45], [46], [48], [49], [50], [53], [54], [55], [56], [58], [59], [23], [60], [105], [61], [62], [63], [64], [66], [68], [69]
D0416		Danazol	C22H27NO2	28417	Major		Inter Info	[106], [107], [13], [21], [1]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[72], [36], [39], [40], [44], [73], [74], [21], [60], [75], [76], [77], [78], [79], [80], [81], [82], [61]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[108]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[15], [21], [25], [109], [1], [91], [110]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[72], [9], [36], [39], [40], [44], [73], [74], [21], [60], [75], [76], [77], [78], [79], [80], [81], [82], [61]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Major		Inter Info	[21], [114], [115]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[98], [99], [35], [100], [36], [37], [10], [38], [39], [11], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [21], [57], [58], [59], [23], [60], [101], [25], [1], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[117], [8], [9], [15], [45], [54], [56], [71], [57], [58], [118]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[70], [42], [45], [47], [51], [52], [54], [56], [71], [21], [57], [58], [65], [67]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[121]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Major		Inter Info	[1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[122]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[123]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[125], [126], [127]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[98], [99], [100], [9], [38], [48], [50], [53], [21], [23], [101], [25], [129], [1], [63], [66]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[8], [9], [42], [45], [51], [52], [54], [56], [71], [57], [58], [25], [131], [1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[72], [9], [36], [39], [40], [44], [73], [74], [21], [60], [75], [76], [77], [78], [79], [80], [81], [82], [61]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[35], [36], [37], [10], [38], [39], [11], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [21], [57], [58], [59], [23], [60], [135], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[136], [25], [1]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[72], [36], [39], [40], [44], [73], [74], [21], [60], [75], [76], [77], [78], [79], [80], [81], [82], [61]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[35], [36], [37], [10], [38], [39], [11], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [21], [57], [58], [59], [23], [60], [25], [1], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[98], [99], [35], [100], [36], [37], [10], [38], [39], [11], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [21], [57], [58], [59], [23], [60], [101], [25], [1], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[49], [18], [21]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[35], [36], [37], [10], [38], [39], [11], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [50], [53], [54], [55], [56], [21], [57], [58], [59], [23], [60], [25], [137], [1], [61], [62], [63], [64], [65], [66], [67], [68], [69], [91]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[9], [42], [45], [51], [52], [54], [56], [71], [57], [58], [186], [187]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[199]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[106], [35], [181]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[217], [218]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[106], [35], [181]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[232]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[234]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[236]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[106], [35], [181]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[9], [42], [45], [51], [52], [54], [56], [71], [57], [58], [186], [187]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[106], [35], [181]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[254]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[229]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[9], [269]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[171], [172], [106], [5], [35], [32], [72], [6], [37], [10], [38], [107], [93], [39], [11], [40], [41], [42], [13], [43], [14], [45], [46], [48], [49], [16], [50], [51], [52], [173], [53], [54], [18], [55], [56], [71], [73], [19], [174], [21], [57], [58], [22], [59], [23], [175], [176], [25], [177], [1], [28], [94], [178], [62], [63], [64], [66], [179], [68], [69], [180], [181], [182]
	CYP450 enzyme induction					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[8], [9], [124]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[132], [133], [134]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[9], [163], [164]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[165]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[166], [26], [1], [167]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[190], [191]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[190], [191]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[8], [203], [204], [205], [206], [207]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[212]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[8], [9], [214]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[8], [219]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[225]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[226], [8], [9], [227]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[228]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[9], [229], [230]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[231]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[235]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[237]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[238]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[8], [203], [204], [205], [206], [207]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[9], [241]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[242], [243], [244]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[251], [252]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[9], [253]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[8], [9], [260]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[8], [9], [261], [260]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[132], [15], [262]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[9], [266]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[8], [9], [260]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[275], [276], [277], [278], [279], [280], [281]
	Competitive inhibition of metabolic enzyme					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[132], [197], [62]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[132], [197], [62]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[132], [197], [62]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[132], [197], [62]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[255], [256], [257], [258], [259]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[255], [256], [257], [258], [259]
D0418		Dapagliflozin	C21H25ClO6	9887712	Minor		Inter Info	[290]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[117], [119], [120]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[128]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[130]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[117], [119], [120]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[152], [153], [154], [8], [9], [155], [156], [157], [158], [159], [160], [161], [162]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[185]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[8], [9], [192]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[193], [194], [195], [196]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[193], [194], [195], [196]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[9], [198]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[152], [153], [154], [8], [9], [155], [156], [157], [158], [159], [160], [161], [162]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[152], [153], [154], [8], [9], [155], [156], [157], [158], [159], [160], [161], [162]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[208]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[210], [211]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[152], [153], [154], [8], [9], [155], [156], [157], [158], [159], [160], [161], [162]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[9], [213]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[166], [176], [26]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[240]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[8], [245], [115]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[193], [194], [195], [196]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[8], [9], [248], [249], [250]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[9], [270]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[273], [274]
	Increased risk of peripheral neuropathy					Drug Num: 65
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[168], [169], [170]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[168], [169], [170]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[168], [169], [170]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[168], [169], [170]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[168], [169], [170]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[168], [169], [170]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[168], [169], [170]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[168], [169], [170]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[168], [169], [170]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[168], [169], [170]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[168], [169], [170]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[168], [169], [170]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[168], [169], [170]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[168], [169], [170]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[168], [169], [170]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[168], [169], [170]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[168], [169], [170]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[168], [169], [170]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[168], [169], [170]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[168], [169], [170]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[168], [169], [170]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[168], [169], [170]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[168], [169], [170]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[168], [169], [170]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[168], [169], [170]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[168], [169], [170]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[168], [169], [170]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[168], [169], [170]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[168], [169], [170]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[168], [169], [170]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[168], [169], [170]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[168], [169], [170]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[168], [169], [170]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[168], [169], [170]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[168], [169], [170]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[168], [169], [170]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[168], [169], [170]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[168], [169], [170]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[168], [169], [170]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[168], [169], [170]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[168], [169], [170]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[168], [169], [170]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[168], [169], [170]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[168], [169], [170]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[168], [169], [170]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[168], [169], [170]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[168], [169], [170]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[168], [169], [170]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[168], [169], [170]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[168], [169], [170]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[168], [169], [170]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[168], [169], [170]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[168], [169], [170]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[168], [169], [170]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[168], [169], [170]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[267], [8], [9], [268]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[168], [169], [170]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[168], [169], [170]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[267], [272]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[168], [169], [170]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[168], [169], [170]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[168], [169], [170]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[168], [169], [170]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[168], [169], [170]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[168], [169], [170]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[246], [9], [247]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0360		Clofibrate	C12H15ClO3	2796	Major		Inter Info	[2], [3], [4]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[9], [83], [84]
D1129		Niacin	C6H5NO2	938	Major		Inter Info	[85], [86], [87]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[102], [103], [104]
D0642		Fenofibrate	C20H21ClO4	3339	Major		Inter Info	[2], [3], [4]
D0643		Fenofibric acid	C17H15ClO4	64929	Major		Inter Info	[111], [112]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[3], [4], [113]
D0421		Daptomycin	C72H101N17O26	16134395	Moderate		Inter Info	[85], [87], [189]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[264], [265]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[264], [265]

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75	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
76	Product Information. Crixivan (indinavir). Merck & Co, Inc, West Point, PA.
77	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
78	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
79	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
80	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
81	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
82	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
83	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
84	EMA. European Medicines Agency. Committee for Medicinal Products for Human Use (CHMP) "Revlimid."
85	Product Information. Vytorin (ezetimibe-simvastatin). Merck &amp Company Inc, West Point, PA.
86	Product Information. Mevacor (lovastatin). Merck &amp Co, Inc, West Point, PA.
87	Product Information. Zocor (simvastatin). Merck &amp Co, Inc, West Point, PA.
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123	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
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127	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
128	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
129	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
130	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
131	Product Information. Noxafil (posaconazole). Schering-Plough Corporation, Kenilworth, NJ.
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136	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
137	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
138	Product Information. Actemra (tocilizumab). Genentech, South San Francisco, CA.
139	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
140	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
141	Product Information. Cosentyx (secukinumab). Novartis Pharmaceuticals, East Hanover, NJ.
142	Product Information. Gamifant (emapalumab). Sobi Inc, Ardmore, PA.
143	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
144	Product Information. Ilumya (tildrakizumab). Merck & Company Inc, Whitehouse Station, NJ.
145	Product Information. Kevzara (sarilumab). sanofi-aventis, Bridgewater, NJ.
146	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
147	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
148	Product Information. Skyrizi (risankizumab). AbbVie US LLC, North Chicago, IL.
149	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
150	Product Information. Sylvant (siltuximab). Janssen Biotech, Inc., Horsham, PA, PA.
151	Product Information. Taltz Autoinjector (ixekizumab). Eli Lilly and Company, Indianapolis, IN.
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158	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
159	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
160	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
161	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
162	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
163	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
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166	Product Information. Crestor (rosuvastatin). AstraZeneca Pharma Inc, Mississauga, ON.
167	Ucar M, Neuvonen M, Luurila H, Dahlqvist R, Neuvonen PJ, Mjorndal T "Carbamazepine markedly reduces serum concentrations of simvastatin and simvastatin acid." Eur J Clin Pharmacol 59 (2003): 879-82. [PMID: 14691614]
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175	Product Information. Baycol (cerivastatin). Bayer, West Haven, CT.
176	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
177	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
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183	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
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185	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
186	Niwa T, Shiraga T, Takagi A "Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, CYP3A4 activities in human liver microsomes." Biol Pharm Bull 28 (2005): 1805-8. [PMID: 16141567]
187	Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
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189	Product Information. Cubicin (daptomycin). Cubist Pharmaceuticals Inc, Lexington, MA.
190	Gerber JG, Rosenkranz SL, Fichtenbaum CJ, et al. "Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study." J Acquir Immune Defic Syndr 39 (2005): 307-12. [PMID: 15980690]
191	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
192	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
193	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
194	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
195	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
196	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
197	Pauli-Magnus C, Rekersbrink S, Klotz U, Fromm MF "Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein." Naunyn Schmiedebergs Arch Pharmacol 364 (2001): 551-7. [PMID: 11770010]
198	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
199	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
200	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
201	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
202	Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
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204	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
205	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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208	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
209	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
210	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
211	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
212	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
213	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
214	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
215	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
216	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
217	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
218	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
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220	Product Information. Cozaar (losartan). Merck &amp Co, Inc, West Point, PA.
221	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
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224	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
225	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
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227	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
228	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
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230	Product Information. Aptiom (eslicarbazepine). Sunovion Pharmaceuticals Inc, Marlborough, MA.
231	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
232	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
233	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
234	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
235	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
236	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
237	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
238	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
239	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
240	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
241	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
242	Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
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248	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
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250	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
251	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
252	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
253	Product Information. Banzel (rufinamide). Eisai Inc, Teaneck, NJ.
254	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
255	Barshes NR, Goodpastor SE, Goss JA "Sirolimus-atorvastatin drug interaction in the pancreatic islet transplant recipient." Transplantation 76 (2003): 1649-50. [PMID: 14702546]
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258	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
259	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
260	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
261	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
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263	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
264	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
265	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.
266	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
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269	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
270	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
271	Product Information. Epclusa (sofosbuvir-velpatasvir). Gilead Sciences, Foster City, CA.
272	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
273	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
274	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
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280	Product Information. Rezulin (troglitazone). Parke-Davis, Morris Plains, NJ.
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