Drug General Information (ID: DDII0FBRZH)
Drug Name			Mycophenolate mofetil		Drug Info		Colesevelam		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Immunosuppressive Agents				Bile Acid Sequestrants
Structure

Mechanism of Mycophenolate mofetil-Colesevelam Interaction (Severity Level: Major)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Mycophenolate mofetil				Colesevelam
Mechanism		Binds to anion exchange resin/polymer				Anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Colesevelam due to formation of complexes caused by Mycophenolate mofetil

Recommended Action
Management		Given the risk of organ rejection associated with inadequate immunosuppressant blood levels, mycophenolic acid products should not be administered with cholestyramine or other agents that may interfere with enterohepatic recirculation or bind bile acids (e.g., activated charcoal).

References
1	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.