Drug General Information (ID: DDIRQZ7DM2)
Drug Name			Dicoumarol		Drug Info		Phylloquinone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticoagulants				Vitamins
Structure

Mechanism of Dicoumarol-Phylloquinone Interaction (Severity Level: Moderate)
Antagonize the effect of antithrombotic agents Click to Show/Hide Mechanism Graph
Drug Name		Dicoumarol				Phylloquinone
Mechanism		Vitamin K antagonist				Vitamin K analogs
Key Mechanism Factor 1
		Factor Name		Antithrombotic agents
		Factor Description		The beneficial effects of antithrombotic agents are reduced, leading to an increased risk of thromboembolism, stroke and/or myocardial infarction.
Mechanism Description		Antagonize the effect of Dicoumarol when combined with Phylloquinone

Recommended Action
Management		Intake of vitamin K through supplements or diet should not vary significantly during oral anticoagulant therapy. The International Normalization Ratio (INR) should be monitored and anticoagulant dosage adjusted as necessary.

References
1	Howard PA, Hannaman KN "Warfarin resistance linked to enteral nutrition products." J Am Diet Assoc 85 (1985): 713-5. [PMID: 3998343]
2	Kempin SJ "Warfarin resistance caused by broccoli." N Engl J Med 308 (1983): 1229-30. [PMID: 6843604]
3	Lee M, Schwartz RN, Sharifi R "Warfarin resistance and vitamin K." Ann Intern Med 94 (1981): 140-1. [PMID: 7447217]