Drug General Information (ID: DDIJ8YSBVE)
Drug Name			Doxepin		Drug Info		Cholestyramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidepressants				Bile Acid Sequestrants
Structure

Mechanism of Doxepin-Cholestyramine Interaction (Severity Level: Minor)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Doxepin				Cholestyramine
Mechanism 1		Tricyclic antidepressants				Absorption decreased by tricyclic antidepressants
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Cholestyramine caused by Doxepin
Mechanism 2		Tricyclic antidepressant				Absorption decreased by tricyclic antidepressants
Key Mechanism Factor 2
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Cholestyramine caused by Doxepin

References
1	Bailey DN, Coffee JJ, Anderson B, Manoguerra AS "Interaction of tricyclic antidepressants with cholestyramine in vitro." Ther Drug Monit 14 (1992): 339-42. [PMID: 1519310]
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Spina E, Avenoso A, Campo GM, Caputi AP, Perucca E "Decreased plasma concentrations of imipramine and desipramine following cholestyramine intake in depressed patients." Ther Drug Monit 16 (1994): 432-4. [PMID: 7974637]