Drug General Information (ID: DDIEO98L4K)
  Drug Name Meloxicam Drug Info Cholestyramine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Nsaids/Analgesics Bile Acid Sequestrants
  Structure

 Mechanism of Meloxicam-Cholestyramine Interaction (Severity Level: Minor)
     Complex formation Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Meloxicam Cholestyramine
      Mechanism Binds to anion exchange resin/polymer Anion exchange resin/polymer
      Key Mechanism Factor 1
Factor Name Chelation
Factor Description Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
      Mechanism Description
  • Decreased absorption of Cholestyramine due to formation of complexes caused by Meloxicam 

References
1 Ferry DG, Gazeley LR, Busby WJ, Beasley DMG, Edwards IR, campbell AJ "Enhanced elimination of piroxicam by administration of activated charcoal or cholestyramine." Eur J Clin Pharmacol 39 (1990): 599-601. [PMID: 2095346]
2 Guentert TW, Defoin R, Mosberg H "The influence of cholestyramine on the elimination of tenoxicam and piroxicam." Eur J Clin Pharmacol 34 (1988): 283-9. [PMID: 3260866]