Drug General Information (ID: DDIMXNR0JU)
Drug Name			Cerivastatin		Drug Info		Cholestyramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Statins/Antihyperlipidemic Agents				Bile Acid Sequestrants
Structure

Mechanism of Cerivastatin-Cholestyramine Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Cerivastatin				Cholestyramine
Mechanism		Binds to anion exchange resin/polymer				Anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Cholestyramine due to formation of complexes caused by Cerivastatin

Recommended Action
Management		If simultaneous therapy with both agents is desired, cerivastatin should be administered several hours after the bile acid binding resin.

References
1	Muck W, Ritter W, Frey R, Wetzelsberger N, Lucker PW, Kuhlmann J "Influence of cholestyramine on the pharmacokinetics of cerivastatin." Int J Clin Pharmacol Ther 35 (1997): 1997. [PMID: 9208341]
2	Product Information. Baycol (cerivastatin). Bayer, West Haven, CT.
3	Smith HT, Jokubaitis LA, Troendle AJ, Hwang DS, Robinson WT "Pharmacokinetics of fluvastatin and specific drug interactions." Am J Hypertens 6 (1993): s375-82. [PMID: 8297546]