Details of Drug

Drug General Information (ID: D0303)
Drug Name	Cerivastatin
Drug Type	Small molecule
Drug Synonymous	cerivastatin; Baycol; cerivastatin acid; Lipobay; 145599-86-6; Cerivastatin [INN:BAN]; UNII-AM91H2KS67; CHEBI:3558; AM91H2KS67; HSDB 7357; (3R,5S,6E)-7-(4-(p-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoic acid; (3R,5S,6E)-7-(4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-6-heptenoic acid; 143201-11-0; 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, (3R,5S,6E)-; Statins Click to Show/Hide
Disease Class	5C80: Hyper-lipoproteinaemia; 2A83: Multiple myeloma
Therapeutic Class	Statins/Antihyperlipidemic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C26H34FNO5
InChI	1S/C26H34FNO5/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32)/b11-10+/t19-,20-/m1/s1
InChIKey	SEERZIQQUAZTOL-ANMDKAQQSA-N
Canonical SMILES	CC(C)C1=C(C(=C(C(=N1)C(C)C)COC)C2=CC=C(C=C2)F)C=CC(CC(CC(=O)O)O)O
External Link
	Pubchem ID	446156
	CAS Number	145599-86-6
	CHEBI ID	3558
	TTD ID	D03KIA
	VARIDT ID	DR00391

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM003 Complex formation BM009 Altered absorption (Unspecific) BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Cerivastatin
Affected gastrointestinal absorption
	Complex formation					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[133], [31], [134]
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[134]
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1233		Pectin	C6H10O7	441476	Moderate		Inter Info	[170], [84]
Affected cellular transport
	Transporter inhibition					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[65], [66], [67]
D0155		Bempedoic acid	C19H36O5	10472693	Moderate		Inter Info	[130], [131]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[65], [66], [136], [137], [138], [139]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[66], [140]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[146], [65], [147]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[65], [148], [149]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[66], [150]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[157]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[158]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[160]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[162]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[66]
D1436		Sacubitril	C24H29NO5	9811834	Moderate		Inter Info	[77], [66], [84]
	Transporter induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[66], [119]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 62
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[4], [1], [5], [6], [2], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [8], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[20], [1], [21], [23], [44], [5], [24], [6], [25], [45], [26], [2], [46], [27], [47], [48], [49], [50], [51], [29], [52], [53], [30], [54], [9], [55], [18], [36], [56], [37], [57], [39], [40]
D0416		Danazol	C22H27NO2	28417	Major		Inter Info	[58], [59], [45], [8], [32], [33], [34]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[4], [1], [5], [6], [2], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[68], [69], [46], [70], [71], [72], [51], [52], [73], [8], [74], [53], [75], [76]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[68], [69], [46], [70], [71], [72], [51], [52], [73], [8], [74], [53], [75], [76]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[83], [84]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[86], [87], [88], [44], [47], [49], [50], [8], [54], [89], [56], [57]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[65], [66], [69], [46], [71], [72], [51], [52], [73], [74], [53], [33], [94], [34]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[4], [1], [5], [6], [2], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[4], [1], [5], [6], [2], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[24], [25], [32]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[4], [1], [5], [6], [2], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[68], [69], [46], [70], [71], [72], [51], [52], [73], [8], [74], [53], [75], [76]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [8], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[4], [1], [5], [6], [2], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[4], [1], [5], [6], [2], [7], [3], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[117]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[77], [66], [118]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[58], [20], [113]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[141], [142]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[58], [20], [113]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[58], [20], [113]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[159]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[58], [20], [113]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[161]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[58], [20], [113]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[66], [69], [46], [71], [72], [51], [52], [73], [74], [53], [167], [168]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[58], [20], [113]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[58], [20], [113]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[58], [20], [113]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[8], [179], [84]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[58], [20], [113]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[65], [66]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[192]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[58], [20], [113]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[66], [69], [46], [71], [72], [51], [52], [73], [74], [53], [167], [168]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[98], [19], [58], [99], [20], [100], [4], [101], [21], [23], [44], [59], [102], [5], [24], [6], [25], [69], [45], [26], [103], [46], [27], [47], [48], [104], [49], [71], [72], [28], [50], [51], [105], [29], [52], [73], [7], [106], [107], [8], [74], [53], [108], [30], [54], [31], [32], [33], [109], [34], [110], [111], [35], [36], [56], [37], [57], [38], [39], [40], [112], [113], [114]
	CYP450 enzyme induction					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[132]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[65], [143]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[144], [145]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[151], [65], [66], [152]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[156]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[163]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[164], [66], [165]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[66], [178]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[65], [66], [185]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[66], [188]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[144], [145]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[65], [66], [185]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[196], [197], [198], [199], [200]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[196], [197], [198], [199], [200]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[180], [181], [182], [183], [184]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[180], [181], [182], [183], [184]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[77], [78], [79]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[82]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[85]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[93]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[77], [78], [79]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[115], [65], [116]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[120], [115], [121], [65], [66], [122], [123], [124], [125], [126], [127], [116], [128]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[129]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[135]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[65], [66], [153]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[154], [32], [155]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[66], [166]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[169]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[171], [172], [173], [174]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[65], [66], [175], [176], [177]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[66], [191]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[171], [172], [173], [174]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[171], [172], [173], [174]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[120], [115], [121], [65], [66], [122], [123], [124], [125], [126], [127], [116], [128]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[194], [195]
	Increased risk of peripheral neuropathy					Drug Num: 59
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[95], [96], [97]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[95], [96], [97]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[95], [96], [97]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[95], [96], [97]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[95], [96], [97]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[95], [96], [97]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[95], [96], [97]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[95], [96], [97]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[95], [96], [97]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[95], [96], [97]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[95], [96], [97]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[95], [96], [97]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[95], [96], [97]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[95], [96], [97]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[95], [96], [97]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[95], [96], [97]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[95], [96], [97]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[95], [96], [97]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[95], [96], [97]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[95], [96], [97]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[95], [96], [97]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[95], [96], [97]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[95], [96], [97]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[95], [96], [97]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[95], [96], [97]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[95], [96], [97]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[95], [96], [97]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[95], [96], [97]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[95], [96], [97]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[95], [96], [97]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[95], [96], [97]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[95], [96], [97]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[95], [96], [97]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[95], [96], [97]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[95], [96], [97]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[95], [96], [97]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[95], [96], [97]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[95], [96], [97]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[95], [96], [97]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[95], [96], [97]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[95], [96], [97]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[189], [65], [190]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[95], [96], [97]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[95], [96], [97]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[95], [96], [97]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[95], [96], [97]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[95], [96], [97]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[95], [96], [97]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[95], [96], [97]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[189], [193]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[95], [96], [97]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[95], [96], [97]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[95], [96], [97]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[95], [96], [97]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[95], [96], [97]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[95], [96], [97]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[95], [96], [97]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[95], [96], [97]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[95], [96], [97]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[41], [42], [43]
D0642		Fenofibrate	C20H21ClO4	3339	Major		Inter Info	[60], [61], [62]
D0643		Fenofibric acid	C17H15ClO4	64929	Major		Inter Info	[63], [64]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[60], [61], [62]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[66], [80], [81]
D1129		Niacin	C6H5NO2	938	Major		Inter Info	[90], [91], [92]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[186], [187]

References
1	Cheng CH, Miller C, Lowe C, Pearson VE "Rhabdomyolysis due to probable interaction between simvastatin and ritonavir." Am J Health Syst Pharm 59 (2002): 728-30. [PMID: 11977859]
2	Hare CB, Vu MP, Grunfeld C, Lampiris HW "Simvastatin-nelfinavir interaction implicated in rhabdomyolysis and death." Clin Infect Dis 35 (2002): E111-2. [PMID: 12410494]
3	Mangum EM, Graham KK "Lopinavir-Ritonavir: a new protease inhibitor." Pharmacotherapy 21 (2001): 1352-63. [PMID: 11714208]
4	Barry M, Mulcahy F, Merry C, Gibbons S, Back D "Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection." Clin Pharmacokinet 36 (1999): 289-304. [PMID: 10320951]
5	Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57. [PMID: 10668858]
6	Fichtenbaum CJ, Gerber JG, Rosenkranz SL, et al. "Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: ACTG Study A5047." AIDS 16 (2002): 569-577. [PMID: 11873000]
7	Malaty LI, Kuper JJ "Drug interactions of HIV protease inhibitors." Drug Safety 20 (1999): 147-69. [PMID: 10082072]
8	Neuvonen PJ, Backman JT, Niemi M "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin." Clin Pharmacokinet 47 (2008): 463-74. [PMID: 18563955]
9	Piliero PJ "Interaction between ritonavir and statins." Am J Med 112 (2002): 510-1. [PMID: 11959074]
10	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
11	Product Information. Crixivan (indinavir). Merck & Co, Inc, West Point, PA.
12	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
13	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
14	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
15	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
16	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
17	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
18	Schmidt GA, Hoehns JD, Purcell JL, Friedman RL, Elhawi Y "Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir." J Am Board Fam Med 20 (2007): 411-6. [PMID: 17615423]
19	Amsden GW, Kuye O, Wei GC "A study of the interaction potential of azithromycin and clarithromycin with atorvastatin in healthy volunteers." J Clin Pharmacol 42 (2002): 444-9. [PMID: 11936570]
20	Ayanian JZ, Fuchs CS, Stone RM "Lovastatin and rhabdomyolysis." Ann Intern Med 109 (1988): 682-3. [PMID: 3421582]
21	Chouhan UM, Chakrabarti S, Millward LJ "Simvastatin interaction with clarithromycin and amiodarone causing myositis." Ann Pharmacother 39 (2005): 1760-1. [PMID: 16159992]
22	Cooper JM, Jones AL "Neuroleptic malignant syndrome or a statin drug reaction? A case report." Clin Neuropharmacol 32 (2009): 348-9. [PMID: 19952877]
23	Corpier CL, Jones PH, Suki WN, et al. "Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients." JAMA 260 (1988): 239-41. [PMID: 3290520]
24	East C, Alivizatos PA, Grundy SM, Jones PH, Farmer JA "Rhabdomyolysis in patients receiving lovastatin after cardiac transplantation." N Engl J Med 318 (1988): 47-8. [PMID: 3275892]
25	Garnett WR "Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors." Am J Health Syst Pharm 52 (1995): 1639-45. [PMID: 7583826]
26	Grunden JW, Fisher KA "Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin." Ann Pharmacother 31 (1997): 859-63. [PMID: 9220046]
27	Huynh T, Cordato D, Yang F, et al. "HMG coA reductase-inhibitor-related myopathy and the influence of drug interactions." Intern Med J 32(9-10) (2002): 486-90. [PMID: 12380704]
28	Kantola T, Kivisto KT, Neuvonen PJ "Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations." Clin Pharmacol Ther 64 (1998): 177-82. [PMID: 9728898]
29	Lee AJ, Maddix DS "Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin." Ann Pharmacother 35 (2001): 26-31. [PMID: 11197581]
30	Omar MA, Wilson JP "FDA adverse event reports on statin-associated rhabdomyolysis." Ann Pharmacother 36 (2002): 288-95. [PMID: 11847951]
31	Product Information. Baycol (cerivastatin). Bayer, West Haven, CT.
32	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
33	Product Information. Mevacor (lovastatin). Merck & Co, Inc, West Point, PA.
34	Product Information. Zocor (simvastatin). Merck & Co, Inc, West Point, PA.
35	Siedlik PH, Olson SC, Yang BB, Stern RH "Erythromycin coadministration increases plasma atorvastatin concentrations." J Clin Pharmacol 39 (1999): 501-4. [PMID: 10234598]
36	Sipe BE, Jones RJ, Bokhart GH "Rhabdomyolysis Causing AV Blockade Due to Possible Atorvastatin, Esomeprazole, and Clarithromycin Interaction." Ann Pharmacother 37 (2003): 808-11. [PMID: 12773066]
37	Spach DH, Bauwens JE, Clark CD, Burke WG "Rhabdomyolysis associated with lovastatin and erythromycin use." West J Med 154 (1991): 213-5. [PMID: 2006579]
38	Westphal JF "Macrolide - induced clinically relevant drug interactions with cytochrome P-450 (CYP) 3A4: an update focused on clarithromycin, azithromycin, and dirithromycin." Br J Clin Pharmacol 50 (2000): 285-95. [PMID: 11012550]
39	Williams D, Feely J "Pharmacokinetic-Pharmacodynamic Drug Interactions with HMG-CoA Reductase Inhibitors." Clin Pharmacokinet 41 (2002): 343-70. [PMID: 12036392]
40	Wong PW, Dillard TA, Kroenke K "Multiple organ toxicity from addition of erythromycin to long-term lovastatin therapy." South Med J 91 (1998): 202-5. [PMID: 9496876]
41	Colchicine: serious interactions. Prescrire Int 17 (2008): 151-3. [PMID: 19492485]
42	Wilbur K, Makowsky M "Colchicine myotoxicity: case reports and literature review." Pharmacotherapy 24 (2004): 1784-92. [PMID: 15585444]
43	Montiel V, Huberlant V, Vincent MF, Bonbled F, Hantson P "Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management." Clin Toxicol (Phila) 48 (2010): 845-8.[PMID: 20969505]
44	Corsini A, Bellosta S, Baetta R, Fumagalli R, Paoletti R, Bernini F "New insights into the pharmacodynamic and pharmacokinetic properties of statins." Pharmacol Ther 84 (1999): 413-28. [PMID: 10665838]
45	Gruer PJK, Vega JM, Mercuri MF, Dobrinska MR, Tobert JA "Concomitant use of cytochrome P450 3A4 inhibitors and simvastatin." Am J Cardiol 84 (1999): 811-5. [PMID: 10513779]
46	Horn M "Coadministration of itraconazole with hypolipidemic agents may induce rhabdomyolysis in healthy individuals." Arch Dermatol 132 (1996): 1254. [PMID: 8859048]
47	Jacobson RH, Wang P, Glueck CJ "Myositis and rhabdomyolysis associated with concurrent use of simvastatin and nefazodone." JAMA 277 (1997): 296. [PMID: 9002485]
48	Jacobson TA "Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors." Am J Cardiol 94 (2004): 1140-6. [PMID: 15518608]
49	Jody DN "Myositis and rhabdomyolysis associated with concurrent use of simvastatin and nefazodone." JAMA 277 (1997): 296-7. [PMID: 9002485]
50	Karnik NS, Maldonado JR "Antidepressant and statin interactions: a review and case report of simvastatin and nefazodone-induced rhabdomyolysis and transaminitis." Psychosomatics 46 (2005): 565-8. [PMID: 16288136]
51	Kivisto KT, Kantola T, Neuvonen PJ "Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin." Br J Clin Pharmacol 46 (1998): 49-53. [PMID: 9690949]
52	Lees RS, Lees AM "Rhabdomyolysis from the coadministration of lovastatin and the antifungal agent itraconazole." N Engl J Med 333 (1995): 664-5. [PMID: 7637734]
53	Neuvonen PJ, Kantola T, Kivisto KT "Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole." Clin Pharmacol Ther 63 (1998): 332-41. [PMID: 9542477]
54	Paoletti R, Corsini A, Bellosta S "Pharmacological interactions of statins." Atheroscler Suppl 3 (2002): 35-40. [PMID: 12044584]
55	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
56	Skrabal MZ, Stading JA, Monaghan MS "Rhabdomyolysis associated with simvastatin-nefazodone therapy." South Med J 96 (2003): 1034-5. [PMID: 14570351]
57	Thompson M, Samuels S "Rhabdomyolysis with simvastatin and nefazodone." Am J Psychiatry 159 (2002): 1607. [PMID: 12202291]
58	Andreou ER, Ledger S "Potential drug interaction between simvastatin and danazol causing rhabdomyolysis." Can J Clin Pharmacol 10 (2003): 172-4. [PMID: 14712320]
59	Dallaire M, Chamberland M "Severe rhabdomyolysis in a patient receiving lovastatin, danazol and doxycycline." Can Med Assoc J 150 (1994): 1991-4. [PMID: 8199978]
60	Backman JT, Kyrklund C, Neuvonen M, Neuvonen PJ "Gemfibrozil greatly increases plasma concentrations of cerivastatin." Clin Pharmacol Ther 72 (2002): 685-91.[PMID: 12496749]
61	Duell PB, Connor WE, Illingworth DR "Rhabdomyolysis after taking atorvastatin with gemfibrozil." Am J Cardiol 81 (1998): 368-9.[PMID: 9468088]
62	Mastroianni CM, dEttorre G, Forcina G, Lichtner M, Corpolongo A, Coletta S, Vullo V "Rhabdomyolysis after cerivastatin-gemfibrozil therapy in an HIV-infected patient with protease inhibitor-related hyperlipidemia." AIDS 15 (2001): 820-1.[PMID: 11371708]
63	Product Information. Trilipix (fenofibric acid). Abbott Pharmaceutical, Abbott Park, IL.
64	Unal A, Torun E, Sipahioglu MH, et al. "Fenofibrate-induced acute renal failure due to massive rhabdomyolysis after coadministration of statin in two patients." Intern Med 47 (2008): 1017-9.[PMID: 18520113]
65	Cerner Multum, Inc. "Australian Product Information.".
66	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
67	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
68	Akram K, Rao S, Parker M "A lesson for everyone in drug-drug interactions." Int J Cardiol 118 (2007): e19-20. [PMID: 17368833]
69	Gilad R, Lampl Y "Rhabdomyolysis induced by simvastatin and ketoconazole treatment." Clin Neuropharmacol 22 (1999): 295-7. [PMID: 10516882]
70	Itakura H, Vaughn D, Haller DG, O'Dwyer PJ "Rhabdomyolysis from cytochrome p-450 interaction of ketoconazole and simvastatin in prostate cancer." J Urol 169 (2003): 613. [PMID: 12544321]
71	Kantola T, Kivisto KT, Neuvonen PJ "Effect of itraconazole on cerivastatin pharmacokinetics." Eur J Clin Pharmacol 54 (1999): 851-5. [PMID: 10027660]
72	Kantola T, Kivisto KT, Neuvonen PJ "Effect of itraconazole on the pharmacokinetics of atorvastatin." Clin Pharmacol Ther 64 (1998): 58-65. [PMID: 9695720]
73	Lomaestro BM, Piatek MA "Update on drug interactions with azole antifungal agents." Ann Pharmacother 32 (1998): 915-28. [PMID: 9762380]
74	Neuvonen PJ, Jalava KM "Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid." Clin Pharmacol Ther 60 (1996): 54-61. [PMID: 8689812]
75	Stein CA, Goel S, Ghavamian R "Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatin therapy." Invest New Drugs 25 (2007): 277-8. [PMID: 17216557]
76	Watkins JL, Atkinson BJ, Pagliaro LC "Rhabdomyolysis in a prostate cancer patient taking ketoconazole and simvastatin: case report and review of the literature." Ann Pharmacother 45 (2011): e9. [PMID: 21304039]
77	Canadian Pharmacists Association.
78	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
79	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
80	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
81	EMA. European Medicines Agency. Committee for Medicinal Products for Human Use (CHMP) "Revlimid."
82	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
83	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
84	Richter WO, Jacob BG, Schwandt P "Interaction between fibre and lovastatin." Lancet 338 (1991): 706. [PMID: 1679514]
85	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
86	Alderman CP "Possible interaction between nefazodone and pravastatin." Ann Pharmacother 33 (1999): 871. [PMID: 10466919]
87	Alderman CP "Possible interaction between nefazodone and pravastatin." Ann Pharmacother 34 (2000): 538-9. [PMID: 10466919]
88	Bottorf MB "Possible interaction between nefazodone and pravastatin." Ann Pharmacother 34 (2000): 538. [PMID: 10772447]
89	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
90	Product Information. Vytorin (ezetimibe-simvastatin). Merck &amp Company Inc, West Point, PA.
91	Product Information. Mevacor (lovastatin). Merck &amp Co, Inc, West Point, PA.
92	Product Information. Zocor (simvastatin). Merck &amp Co, Inc, West Point, PA.
93	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
94	Product Information. Noxafil (posaconazole). Schering-Plough Corporation, Kenilworth, NJ.
95	Carrion C, Espinosa E, Herrero A, Garcia B "Possible vincristine-isoniazid interaction." Ann Pharmacother 29 (1995): 201. [PMID: 7756727]
96	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
97	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online."
98	Agbin NE, Brater DC, Hall SD "Interaction of diltiazem with lovastatin and pravastatin." Clin Pharmacol Ther 61 (1997): 201. [PMID: 9797793]
99	Arnadottir M, Eriksson LO, Thysell H, Karkas JD "Plasma concentration profiles of simvastatin 3-hydroxy- 3-methylglutaryl-coenzyme A reductase inhibitory activity in kidney transplant recipients with and without ciclosporin." Nephron 65 (1993): 410-3. [PMID: 8289991]
100	Azie NE, Brater DC, Becker PA, Jones DR, Hall SD "The interaction of diltiazem with lovastatin and pravastatin." Clin Pharmacol Ther 64 (1998): 369-77. [PMID: 9797793]
101	Campana C, Iacona I, Regassi MB, et al. "Efficacy and pharmacokinetics of simvastatin in heart transplant recipients." Ann Pharmacother 29 (1995): 235-9. [PMID: 7606066]
102	de Denus S, Spinler SA "Amiodarone's role in simvastatin-associated rhabdomyolysis." Am J Health Syst Pharm 60 (2003): 1791 author reply 1791-2. [PMID: 14503117]
103	Gullestad L, Nordal KP, Berg KJ, Cheng H, Schwartz MS, Simonsen S "Interaction between lovastatin and cyclosporine A after heart and kidney transplantation." Transplant Proc 31 (1999): 2163-5. [PMID: 10456002]
104	Jardine A, Holdaas H "Fluvastatin in combination with cyclosporin in renal transplant recipients: a review of clinical and safety experience." J Clin Pharm Ther 24 (1999): 397-408. [PMID: 10651972]
105	Kusus M, Stapleton DD, Lertora JJL, Simon EE, Dreisbach AW "Rhabdomyolysis and acute renal failure in a cardiac transplant recipient due to multiple drug interactions." Am J Med Sci 320 (2000): 394-7. [PMID: 11149552]
106	Maltz HC, Balog DL, Cheigh JS "Rhabdomyolysis associated with concomitant use of atorvastatin and cyclosporine." Ann Pharmacother 33 (1999): 1176-9. [PMID: 10573315]
107	Mousa O, Brater DC, Sundblad KJ, Hall SD "The interaction of diltiazem with simvastatin." Clin Pharmacol Ther 67 (2000): 267-74. [PMID: 10741630]
108	Norman DJ, Illingworth DR, Munson J, Hosenpud J "Myolysis and acute renal failure in a heart-transplant recipient receiving lovastatin." N Engl J Med 318 (1988): 46-7. [PMID: 3275891]
109	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
110	Rodriguez JA, CrespoLeiro MG, Paniagua MJ, Cuenca JJ, Hermida LF, Juffe A, CastroBeiras A "Rhabdomyolysis in heart transplant patients on HMG-CoA reductase inhibitors and cyclosporine." Transplant Proc 31 (1999): 2522-3. [PMID: 10500698]
111	Roten L, Schoenenberger RA, Krahenbuhl S, Schlienger RG "Rhabdomyolysis in association with simvastatin and amiodarone." Ann Pharmacother 38 (2004): 978-81. [PMID: 15069169]
112	Yeo KR, Yeo WW "Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes." Br J Clin Pharmacol 51 (2001): 461-70. [PMID: 11422004]
113	Yeo KR, Yeo WW, Wallis EJ, Ramsay LE "Enhanced cholesterol reduction by simvastatin in diltiazem-treated patients." Br J Clin Pharmacol 48 (1999): 610-5. [PMID: 10583033]
114	Zhou LX, Finley DK, Hassell AE, Holtzman JL "Pharmacokinetic interaction between isradipine and lovastatin in normal, female and male volunteers." J Pharmacol Exp Ther 273 (1995): 121-7. [PMID: 7714757]
115	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
116	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
117	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
118	Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
119	Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
120	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
121	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
122	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
123	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
124	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
125	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
126	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
127	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
128	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
129	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
130	Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
131	Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
132	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
133	Muck W, Ritter W, Frey R, Wetzelsberger N, Lucker PW, Kuhlmann J "Influence of cholestyramine on the pharmacokinetics of cerivastatin." Int J Clin Pharmacol Ther 35 (1997): 1997. [PMID: 9208341]
134	Smith HT, Jokubaitis LA, Troendle AJ, Hwang DS, Robinson WT "Pharmacokinetics of fluvastatin and specific drug interactions." Am J Hypertens 6 (1993): s375-82. [PMID: 8297546]
135	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
136	Product Information. Evotaz (atazanavir-cobicistat). Bristol-Myers Squibb, Princeton, NJ.
137	Product Information. Prezcobix (cobicistat-darunavir). Janssen Pharmaceuticals, Titusville, NJ.
138	Product Information. Symtuza (cobicistat/darunavir/emtricitabine/tenof). Janssen Pharmaceuticals, Titusville, NJ.
139	Suttels V, Florence E, Leys J, et al. "A 68-year old male presenting with rhabdomyolysis-associated acute kidney injury following concomitant use of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate and pravastatin/fenofibrate: a case report." J Med Case Reports 9 (2015): 190. [PMID: 26347243]
140	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
141	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
142	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
143	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
144	Gerber JG, Rosenkranz SL, Fichtenbaum CJ, et al. "Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study." J Acquir Immune Defic Syndr 39 (2005): 307-12. [PMID: 15980690]
145	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
146	Allred AJ, Bowen CJ, Park JW, et al. "Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers." Br J Clin Pharmacol 72 (2011): 321-9. [PMID: 21434975]
147	Canadian Pharmacists Association "e-CPS."
148	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
149	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
150	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
151	Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
152	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
153	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
154	Product Information. Crestor (rosuvastatin). AstraZeneca Pharma Inc, Mississauga, ON.
155	Product Information. Pravachol (pravastatin). Bristol-Myers Squibb, Princeton, NJ.
156	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
157	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
158	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
159	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
160	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
161	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
162	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
163	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
164	Cerner Multum, Inc. "Canadian Product Information.".
165	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
166	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
167	Niwa T, Shiraga T, Takagi A "Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, CYP3A4 activities in human liver microsomes." Biol Pharm Bull 28 (2005): 1805-8. [PMID: 16141567]
168	Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
169	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
170	Lilja JJ, Kivisto KT, Neuvonen PJ "Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin." Clin Pharmacol Ther 66 (1999): 118-27. [PMID: 10460065]
171	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
172	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
173	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
174	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
175	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
176	Gilead Sciences, Inc "About Remdesivir.".
177	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
178	Product Information. Banzel (rufinamide). Eisai Inc, Teaneck, NJ.
179	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
180	Barshes NR, Goodpastor SE, Goss JA "Sirolimus-atorvastatin drug interaction in the pancreatic islet transplant recipient." Transplantation 76 (2003): 1649-50. [PMID: 14702546]
181	Hibi S, Misawa A, Tamai M, Tsunamoto K, Todo S, Sawada T, Imashuku S "Severe rhabdomyolysis associated with tacrolimus." Lancet 346 (1995): 702. [PMID: 7544861]
182	Kotanko P, Kirisits W, Skrabal F "Rhabdomyolysis and acute renal graft impairment in a patient treated with simvastatin, tacrolimus, and fusidic Acid." Nephron 90 (2002): 234-5. [PMID: 11818715]
183	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
184	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
185	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
186	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
187	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.
188	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
189	Argov Z, Mastaglia FL "Drug-induced peripheral neuropathies." Br Med J 1 (1979): 663-6. [PMID: 219931]
190	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
191	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
192	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
193	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
194	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
195	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
196	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
197	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
198	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
199	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
200	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence