Drug General Information (ID: DDI52GA9JS)
Drug Name			Cerivastatin		Drug Info		Pectin		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Statins/Antihyperlipidemic Agents				Antidiarrheals
Structure

Mechanism of Cerivastatin-Pectin Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Cerivastatin				Pectin
Mechanism		Absorption decreased by fiber				Fiber
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Cerivastatin caused by Pectin

Recommended Action
Management		The clinician should consider avoiding coadministration, but if this is not possible the administration times should be separated as much as possible. Patients should be monitored for altered cholesterol-lowering effects.

References
1	Lilja JJ, Kivisto KT, Neuvonen PJ "Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin." Clin Pharmacol Ther 66 (1999): 118-27. [PMID: 10460065]
2	Richter WO, Jacob BG, Schwandt P "Interaction between fibre and lovastatin." Lancet 338 (1991): 706. [PMID: 1679514]