Drug General Information (ID: DDI9G5ANJ4)
Drug Name			Folic acid		Drug Info		Cholestyramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Bile Acid Sequestrants
Structure

Mechanism of Folic acid-Cholestyramine Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Folic acid				Cholestyramine
Mechanism		Binds to anion exchange resin/polymer				Anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Cholestyramine due to formation of complexes caused by Folic acid

Recommended Action
Management		Patients on prolonged cholestyramine or colestipol therapy should take folic acid supplements at least 1 hour before or 4 to 6 hours after receiving cholestyramine or colestipol.

References
1	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".