Details of Drug

Details of Drug

 Drug General Information (ID: D0688)
  Drug Name
Folic acid
  Drug Type Small molecule
  Drug Synonymous
folic acid; 59-30-3; Folate; Pteroylglutamic acid; Vitamin M; Folacin; Folacid; PteGlu; Vitamin B9; Folvite; Pteroyl-L-glutamic acid; Vitamin Bc; Acifolic; Cytofol; Incafolic; Foliamin; Folsaure; Folicet; Millafol; Folipac; Folettes; Folsan; Folbal; Folsav; Vitamin Be; Pteroyl-L-monoglutamic acid; Mittafol; Folan; Facid; Pteroylmonoglutamic acid; Antianemia factor; Factor U; Folico (Italy); Folina (Italy); Foldine [France]; Pteroylmonoglutamate; Acfol (Spain); Foldine; Folcysteine; Folasic (Australia); Folcidin; Folaemin [Netherlands]; Nifolin; [3H]folic acid
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  Disease Class 5B50-5B71: Nutritional deficiency; 3A02: Folate deficiency anaemia
  Therapeutic Class Vitamins
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C19H19N7O6
  InChI 1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
  InChIKey OVBPIULPVIDEAO-LBPRGKRZSA-N
  Canonical SMILES C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N
  External Link
Pubchem ID 135398658
CAS Number 59-30-3
CHEBI ID 27470
TTD ID D0Z0DW
INTEDE ID DR0742
VARIDT ID DR00134

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM003  Complex formation
BM026  Increased metabolism (Unspecific)
BM083  Potentiated the pharmacological effects (Unspecific)
BM087  Antagonize the effect of antiepileptic agents
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Folic acid
      Affected gastrointestinal absorption
   Complex formation Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0329
 
Cholestyramine
 
C27H47ClN2
 
137699107 
Moderate    Inter Info   
[7], [8]
      Affected intra/extra-hepatic metabolism
   Increased metabolism (Unspecific) Drug Num:  16
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[4], [5], [6]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[4], [5], [6]
D0620
 
Ethosuximide
 
C7H11NO2
 
3291 
Moderate    Inter Info   
[4], [5], [6]
D0621
 
Ethotoin
 
C11H12N2O2
 
3292 
Moderate    Inter Info   
[4], [5], [6]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[4], [5], [6]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[4], [5], [6]
D0890
 
Lamotrigine
 
C9H7Cl2N5
 
3878 
Moderate    Inter Info   
[4], [5], [6]
D1003
 
Mephenytoin
 
C12H14N2O2
 
4060 
Moderate    Inter Info   
[4], [5], [6]
D1032
 
Methsuximide
 
C12H13NO2
 
6476 
Moderate    Inter Info   
[4], [5], [6]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[4], [5], [6]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[4], [5], [6]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[4], [5], [6]
D1269
 
Phensuximide
 
C11H11NO2
 
6839 
Moderate    Inter Info   
[4], [5], [6]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[4], [5], [6]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Moderate    Inter Info   
[4], [5], [6]
D1677
 
Valproic acid
 
C8H16O2
 
3121 
Moderate    Inter Info   
[4], [5], [6]
      Pharmacodynamic additive effects
   Potentiated the pharmacological effects (Unspecific) Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0249
 
Capecitabine
 
C15H22FN3O6
 
60953 
Major    Inter Info   
[1], [2], [3]
D0675
 
Fluorouracil
 
C4H3FN2O2
 
3385 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  7
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[9], [8], [10]
D1366
 
Pyrimethamine
 
C12H13ClN4
 
4993 
Moderate    Inter Info   
[8], [11], [12]
D1514
 
Sulfadoxine
 
C12H14N4O4S
 
17134 
Moderate    Inter Info   
[8], [11], [12]
D1515
 
Sulfamethizole
 
C9H10N4O2S2
 
5328 
Moderate    Inter Info   
[8], [11], [12]
D1516
 
Sulfamethoxazole
 
C10H11N3O3S
 
5329 
Moderate    Inter Info   
[8], [11], [12]
D1631
 
Triamterene
 
C12H11N7
 
5546 
Moderate    Inter Info   
[8], [11], [12]
D1645
 
Trimethoprim
 
C14H18N4O3
 
5578 
Moderate    Inter Info   
[8], [11], [12]
References
1 Product Information. Xeloda (capecitabine). Roche Laboratories, Nutley, NJ.
2 Clippe C, Freyer G, Milano G, Trillet-Lenoir V "Lethal toxicity of capecitabine due to abusive folic acid prescription?" Clin Oncol (R Coll Radiol) 15 (2003): 299-300. [PMID: 12924465]
3 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
4 Berg MJ, Fischer LJ, Rivey MP, Vern BA, Lantz RK, Schottelius DD "Phenytoin and folic acid interaction: a preliminary report." Ther Drug Monit 5 (1983): 389-94. [PMID: 6659012]
5 Katz M "Potential danger of self-medication with folic acid." N Engl J Med 289 (1973): 1095. [PMID: 4742232]
6 Furlanut M, Benetello P, Avogaro A, Dainese R "Effects of folic acid on phenytoin kinetics in healthy subjects." Clin Pharmacol Ther 24 (1978): 294-7. [PMID: 688723]
7 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
8 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9 Cerner Multum, Inc. "Australian Product Information.".
10 Product Information. Methotrexate Sodium (methotrexate). Teva Pharmaceuticals (formerly IVAX), Miami, FL.
11 Mulenga M, Malunga P, Bennett S. et.al "Folic acid treatment of Zambian children with moderate to severe malaria anemia." Am J Trop Med Hyg 74 (2006): 986-90
12 Product Information. Folic Acid (folic acid). Method Pharmaceuticals, LLC, Arlington, TX.