Drug General Information (ID: DDIX9Q6RY4)
Drug Name			Folic acid		Drug Info		Methotrexate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Antimetabolites
Structure

Mechanism of Folic acid-Methotrexate Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Folic acid				Methotrexate
Mechanism		Folate derivatives				Dihydrofolate reductase inhibitor
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Folic acid when combined with Methotrexate

Recommended Action
Management		Although folic acid or folinic acid are frequently used along with methotrexate to reduce adverse effects or as an antidote to high dose methotrexate therapy, patients receiving methotrexate should be advised to avoid the inadvertent use of vitamin preparations containing folic acid or its derivatives.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Methotrexate Sodium (methotrexate). Teva Pharmaceuticals (formerly IVAX), Miami, FL.