Drug General Information (ID: DDID5HJZ4S)
Drug Name			Folic acid		Drug Info		Sulfadoxine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Antimalarial Agents
Structure

Mechanism of Folic acid-Sulfadoxine Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Folic acid				Sulfadoxine
Mechanism		Folate derivatives				Dihydrofolate reductase inhibitor
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Folic acid when combined with Sulfadoxine

Recommended Action
Management		Monitoring of patient response to folic acid supplementation if they are also taking folate antagonists is recommended. This may be especially important for pregnant women taking folic acid to reduce their risk of neural tube defects and in patients with megaloblastic anemia. Folic acid doses greater than 2.5 mg should be avoided in patients receiving pyrimethamine. Patients receiving antifolate antimalarials with folic acid should be monitored for possible treatment failure.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Mulenga M, Malunga P, Bennett S. et.al "Folic acid treatment of Zambian children with moderate to severe malaria anemia." Am J Trop Med Hyg 74 (2006): 986-90
3	Product Information. Folic Acid (folic acid). Method Pharmaceuticals, LLC, Arlington, TX.