Drug General Information (ID: DDIRPIEU0L)
Drug Name			Calcifediol		Drug Info		Cholestyramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Bile Acid Sequestrants
Structure

Mechanism of Calcifediol-Cholestyramine Interaction (Severity Level: Moderate)
Altered Fat-soluble drugs absorption Click to Show/Hide Mechanism Graph
Drug Name		Calcifediol				Cholestyramine
Mechanism		Fat-soluble agent				Decrease fat-soluble agent absorption
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased absorption of Calcifediol caused by Cholestyramine

Recommended Action
Management		Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21. [PMID: 20921291]
4	Product Information. Fosamax Plus D (alendronate-cholecalciferol). Merck & Company Inc, West Point, PA.
5	Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
6	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.