Details of Drug

Drug General Information (ID: D0087)
Drug Name	Anisindione
Drug Type	Small molecule
Drug Synonymous	Anisindiona; Anisindionum; Miradon; Unidone; Anisin indandione; SPE 2792; Anisindiona [INN-Spanish]; Anisindione (INN); Anisindione [INN:BAN]; Anisindionum [INN-Latin]; Miradon (TN); 2-(4-Methoxy-phenyl)-indan-1,3-dione; 2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione; 2-(4-Methoxyphenyl)indan-1,3-dione; 2-(4-methoxyphenyl)indene-1,3-dione; 2-(p-Methoxyphenyl)-1,3-indandione; 2-(p-Methoxyphenyl)indane-1,3-dione; 2-[4-(methyloxy)phenyl]-1H-indene-1,3(2H)-dione; 2-p-Anisyl-1,3-indandione; 2-para-Anisyl-1,3-indandione Click to Show/Hide
Disease Class	3B10: Coagulation defect
Therapeutic Class	Anticoagulants
Structure
Structure	3D Structure		2D Structure
Formula	C16H12O3
InChI	1S/C16H12O3/c1-19-11-8-6-10(7-9-11)14-15(17)12-4-2-3-5-13(12)16(14)18/h2-9,14H,1H3
InChIKey	XRCFXMGQEVUZFC-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
External Link
	Pubchem ID	2197
	CAS Number	117-37-3
	CHEBI ID	133809
	TTD ID	D09WKB

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM003 Complex formation BM008 Altered Fat-soluble drugs absorption BM009 Altered absorption (Unspecific) BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM050 Increased risk of bleeding BM085 Antagonize the effect of antithrombotic agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Anisindione
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0941		Lixisenatide	C215H347N61O65S	90472060	Minor		Inter Info	[38], [31], [546]
	Complex formation					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[253], [214], [91], [254], [255], [256], [27]
D0382		Colestipol	C11H28ClN5O	62816	Minor		Inter Info	[552], [553]
	Altered Fat-soluble drugs absorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[70], [456]
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[497], [498]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0643		Fenofibric acid	C17H15ClO4	64929	Major		Inter Info	[68], [69], [70], [31], [71], [72], [73], [74], [75]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[68], [69], [70], [31], [71], [72], [73], [74], [75]
D0642		Fenofibrate	C20H21ClO4	3339	Major		Inter Info	[68], [69], [70], [31], [71], [72], [73], [74], [75]
D1513		Sulfadiazine	C10H10N4O2S	5215	Major		Inter Info	[181], [182], [183], [144], [145], [147], [184], [133], [50], [185], [186], [121], [187], [188], [150], [189], [151], [152], [139], [54], [27]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Major		Inter Info	[145], [186], [139]
D1517		Sulfasalazine	C18H14N4O5S	5339	Major		Inter Info	[181], [182], [183], [144], [145], [147], [184], [133], [50], [185], [186], [121], [187], [188], [150], [189], [151], [152], [139], [54], [27]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[426], [427]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[442], [443], [444]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[455]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[468], [469]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[426], [427]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[261], [262], [267], [268], [285], [26], [291]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[442], [478], [443], [140], [444], [479], [480], [382]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[442], [443], [444]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[520], [521]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Minor		Inter Info	[541]
D1473		Simvastatin	C25H38O5	54454	Minor		Inter Info	[557], [558], [559], [560], [555], [561], [562], [27]
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[361], [362], [363]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[40], [41], [42], [31], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [27]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[40], [41], [42], [31], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [27]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [26], [139], [27]
D1051		Metronidazole	C6H9N3O3	4173	Major		Inter Info	[143], [144], [145], [146], [147], [133], [148], [149], [150], [151], [152], [139], [27], [153]
D1057		Miconazole	C18H14Cl4N2O	4189	Major		Inter Info	[154], [31], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [27]
D1058		Miconazole (topical)	C18H14Cl4N2O	4189	Major		Inter Info	[155], [165], [168]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[196], [197]
D0040		Allopurinol	C5H4N4O	135401907	Moderate		Inter Info	[208], [209], [210], [211], [212], [213]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[38], [231], [232], [233], [234], [26]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[300], [301], [302], [140], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [27]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[322]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[364], [365], [140], [366], [167], [27], [367]
D1350		Proguanil	C11H16ClN5	6178111	Moderate		Inter Info	[381], [382], [383]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[384], [385], [26], [27]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[300], [301], [302], [140], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [27]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[388]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[144], [145], [133], [400], [151], [152], [401]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[437], [438], [248], [91], [439], [440], [441]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[445], [446], [447], [448], [449], [450], [451], [452], [453], [454], [26], [27]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[34], [295], [459]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[300], [301], [302], [140], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [27]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[474], [26], [475]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[477], [282], [26]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[483], [91], [484], [27]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[364], [365], [140], [366], [167], [27], [367]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[300], [301], [302], [140], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [27]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[486], [487], [488], [26]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[38], [231], [232], [233], [234], [26]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[300], [301], [302], [140], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [27]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[300], [301], [302], [140], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [27]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[295], [513], [514]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[143], [144], [146], [147], [133], [148], [517], [150], [152], [27], [153]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[38], [31], [518], [190], [191], [192], [519]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[539], [540], [26]
D1604		Tolcapone	C14H11NO5	4659569	Minor		Inter Info	[564]
	CYP450 enzyme induction					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0071		Amobarbital	C11H18N2O3	2164	Major		Inter Info	[29], [30], [27]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[86], [29], [87], [88], [89], [90], [91], [92], [30], [93], [94], [27]
D0224		Butabarbital	C10H16N2O3	2479	Major		Inter Info	[86], [29], [87], [88], [89], [90], [91], [92], [30], [93], [94], [27]
D0225		Butalbital	C11H16N2O3	2481	Major		Inter Info	[29], [30], [27]
D1040		Methylphenobarbital	C13H14N2O3	8271	Major		Inter Info	[29], [30], [27]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[86], [29], [87], [88], [89], [90], [91], [92], [30], [93], [94], [27]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[171], [172], [173], [174], [175], [176], [177], [178], [179], [26], [180], [27]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[175], [176], [26]
D1453		Secobarbital	C12H18N2O3	5193	Major		Inter Info	[29], [30], [27]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[38], [31], [229], [230]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[38], [31], [229], [230]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[31], [316]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[144], [145], [133], [323], [324], [325], [152]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[394], [336], [395], [26], [396]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[144], [145], [133], [323], [324], [325], [152]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[420], [421]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[422], [326], [423], [424], [425], [26], [27]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[214], [248], [328]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[248], [91], [481], [482], [26], [27]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[214], [248], [328]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[495], [496]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[326], [214], [248], [327], [328], [329], [26], [27]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[428], [429], [430], [431], [432], [433], [434], [435], [436]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 194
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[3], [4], [5]
D0047		Alteplase	NA	NA	Major		Inter Info	[6], [7], [8], [4], [9], [10], [11], [12], [13], [14]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[28]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[31], [32]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[31], [33]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[34], [35]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[36]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[34], [31], [37]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[38], [31], [39]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[56], [57], [58], [59], [60], [61], [62]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[63], [64]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[31], [65]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[66]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[67]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[56], [57], [58], [59], [60], [61], [62]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[76], [77], [78]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[79], [80], [31], [81]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[31], [63], [82]
D0841		Ipilimumab	NA	NA	Major		Inter Info	[34], [31], [83]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[76], [77], [78]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[76], [77], [78]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[63], [84]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[38], [31], [85]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[95]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[31], [96]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[97]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[31], [98], [99]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[100]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[101]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[38], [31], [102]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[103]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[63]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[104], [105], [106], [107]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[108]
D0249		Capecitabine	C15H22FN3O6	60953	Major		Inter Info	[109], [110], [111]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[76], [77], [78]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[112], [113], [114], [115], [116], [117], [118], [119], [120]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[121], [122], [123]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[121], [122], [123]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[124]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[121], [122], [123]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[121], [122], [123]
D0675		Fluorouracil	C4H3FN2O2	3385	Major		Inter Info	[109], [110], [111]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[121], [122], [123]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[56], [57], [58], [59], [60], [61], [62]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[76], [77], [78]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[140], [141]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[142]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[121], [122], [123]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[121], [122], [123]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[121], [122], [123]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[121], [122], [123]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[104], [105], [107]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[121], [122], [123]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[121], [122], [123]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[121], [122], [123]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[169], [170]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[76], [77], [78]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[121], [122], [123]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[121], [122], [123]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[76], [77], [78]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[121], [122], [123]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[121], [122], [123]
D1395		Reteplase	NA	NA	Major		Inter Info	[6], [7], [8], [4], [9], [10], [11], [12], [13], [14]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[121], [122], [123]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[190], [191], [192]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[6], [7], [8], [4], [9], [10], [11], [12], [13], [14]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[193]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[121], [122], [123]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[194], [195]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Major		Inter Info	[76], [77], [78]
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[198], [199], [200], [201], [202], [203], [204], [205], [206], [27], [207]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[214], [213], [215]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[214], [213], [215]
D0073		Amoxicillin	C16H19N3O5S	33613	Moderate		Inter Info	[216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [91], [226], [121], [187], [227], [54], [228]
D0079		Ampicillin	C16H19N3O4S	6249	Moderate		Inter Info	[216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [91], [226], [121], [187], [227], [54], [228]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[235], [38], [31], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[246], [3], [247], [214], [248], [121], [5], [27]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[235], [31], [236]
D0272		Cefadroxil	C16H17N3O5S	47965	Moderate		Inter Info	[249], [250], [251]
D0276		Cefazolin	C14H14N8O4S3	33255	Moderate		Inter Info	[249], [250], [251]
D0279		Cefepime	C19H24N6O5S2	5479537	Moderate		Inter Info	[249], [250], [251]
D0280		Cefiderocol	C30H34ClN7O10S2	77843966	Moderate		Inter Info	[249], [250], [251]
D0286		Cefotetan	C17H17N7O8S4	53025	Moderate		Inter Info	[249], [250], [251]
D0287		Cefoxitin	C16H17N3O7S2	441199	Moderate		Inter Info	[249], [250], [251]
D0288		Cefpodoxime	C15H17N5O6S2	6335986	Moderate		Inter Info	[249], [250], [251]
D0289		Cefprozil	C18H19N3O5S	5281006	Moderate		Inter Info	[249], [250], [251]
D0291		Ceftaroline fosamil	C22H21N8O8PS4	9852981	Moderate		Inter Info	[249], [250], [251]
D0293		Ceftibuten	C15H14N4O6S2	5282242	Moderate		Inter Info	[249], [250], [251]
D0295		Ceftolozane	C23H30N12O8S2	53234134	Moderate		Inter Info	[249], [250], [251]
D0296		Ceftriaxone	C18H18N8O7S3	5479530	Moderate		Inter Info	[249], [250], [251]
D0310		Chenodeoxycholic acid	C24H40O4	10133	Moderate		Inter Info	[252]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[247], [214], [27]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D1766		Coenzyme M	C2H6O3S2	598	Moderate		Inter Info	[34], [295], [296]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[63], [299]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[214], [213], [215]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[214], [213], [215]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[313], [314], [315]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[326], [214], [248], [327], [328], [329], [26], [27]
D0711		Garlic	NA	NA	Moderate		Inter Info	[330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[335], [345], [346], [339], [342]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[347], [348], [349], [350], [332], [351], [352], [333], [335], [336], [353], [345], [354], [339], [355], [356], [357], [342], [358]
D0794		Imipenem	C12H17N3O4S	104838	Moderate		Inter Info	[34], [31], [295]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[368], [369], [370]
D1843		Methyl salicylate (topical)	C8H8O3	4133	Moderate		Inter Info	[34], [371], [372]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[373], [374], [375]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[376]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[31], [377]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[31], [379], [380]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[247], [214], [27]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[295], [386], [387]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[246], [3], [247], [214], [248], [121], [5], [27]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[389], [390], [391]
D1894		Sugammadex	C72H112O48S8	6918585	Moderate		Inter Info	[31], [397]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[31], [297], [398]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[368], [369], [370]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[31], [399]
D1580		Ticarcillin	C15H16N2O6S2	36921	Moderate		Inter Info	[216], [218], [91]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D1707		Vorinostat	C14H20N2O3	5311	Moderate		Inter Info	[295], [386], [387]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[235], [31], [236]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[408], [409], [410], [183], [411], [412], [49], [413], [414], [415], [416], [417], [54], [418], [419]
D0140		Aztreonam	C13H17N5O8S2	5742832	Moderate		Inter Info	[79], [31]
D0167		Benzylpenicillin	C16H18N2O4S	5904	Moderate		Inter Info	[216], [218], [91]
D0168		Benzylpenicillin (potassium)	C16H18N2O4S	5904	Moderate		Inter Info	[216], [218], [91]
D0169		Benzylpenicillin (sodium)	C16H18N2O4S	5904	Moderate		Inter Info	[216], [218], [91]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[373], [374], [375]
D0257		Carbenicillin	C17H18N2O6S	20824	Moderate		Inter Info	[216], [218], [91]
D0271		Cefaclor	C15H14ClN3O4S	51039	Moderate		Inter Info	[249], [250], [251]
D0277		Cefdinir	C14H13N5O5S2	6915944	Moderate		Inter Info	[249], [250], [251]
D0278		Cefditoren	C19H18N6O5S3	9870843	Moderate		Inter Info	[249], [250], [251]
D0281		Cefixime	C16H15N5O7S2	5362065	Moderate		Inter Info	[249], [250], [251]
D0285		Cefotaxime	C16H17N5O7S2	5742673	Moderate		Inter Info	[249], [250], [251]
D0292		Ceftazidime	C22H22N6O7S2	5481173	Moderate		Inter Info	[249], [250], [251]
D0297		Cefuroxime	C16H16N4O8S	5479529	Moderate		Inter Info	[249], [250], [251]
D0301		Cephalexin	C16H17N3O4S	27447	Moderate		Inter Info	[249], [250], [251]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[457]
D0401		Cycloserine	C3H6N2O2	6234	Moderate		Inter Info	[31], [168], [458]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[27], [460], [461]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[373], [374], [375]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[373], [374], [375]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[462], [463], [464], [465], [466], [467]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[470], [70], [31], [471], [472], [72], [140], [473]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[373], [374], [375]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[476]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[31], [379], [380]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[313], [314], [315]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[214], [213], [215]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[373], [374], [375]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[489], [368], [369], [370], [490], [491]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[492], [493], [494]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[489], [368], [369], [370], [490], [491]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[214], [213], [215]
D1192		Oxacillin	C19H19N3O5S	6196	Moderate		Inter Info	[216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [91], [226], [121], [187], [227], [54], [228]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[235], [38], [31], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[63], [499]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[70], [500]
D1268		Phenoxymethylpenicillin	C16H18N2O5S	6869	Moderate		Inter Info	[216], [218], [91]
D1296		Piperacillin	C23H27N5O7S	43672	Moderate		Inter Info	[216], [218], [91]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[214], [213], [215]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[248], [91], [504]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[248], [91], [504]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[34], [295], [508]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[260], [289], [290]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[31], [509]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[510], [511], [512]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[373], [374], [375]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[515], [140], [516]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[313], [314], [315]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[79], [31]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[214], [213], [215]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[257], [258], [259], [260], [38], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[389], [524], [31], [525], [526], [527], [528], [335], [529], [530], [531], [532], [533], [534], [535], [390], [536], [537], [391], [538]
D0253		Capsicum	NA	NA	Minor		Inter Info	[359]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[359], [542], [339]
D0368		Clove	NA	NA	Minor		Inter Info	[335], [543], [544], [545]
D1173		Olsalazine	C14H10N2O6	22419	Minor		Inter Info	[34], [295], [547]
D1856		Papaya	C15H22O2	61446	Minor		Inter Info	[333], [359], [339]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[549], [335], [550]
D0120		Atorvastatin	C33H35FN2O5	60823	Minor		Inter Info	[551]
D1329		Pravastatin	C23H36O7	54687	Minor		Inter Info	[554], [555], [556]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[31], [297], [298]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[31], [297], [298]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[248], [91], [317], [318], [319], [320], [321]
D0608		Estramustine	C23H31Cl2NO3	259331	Moderate		Inter Info	[318], [320], [321]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[318], [320], [321]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[318], [320], [321]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[359], [360], [342]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[318], [320], [321]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[34], [295], [378]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[31], [297], [298]
D1490		Sofosbuvir	C22H29FN3O9P	45375808	Moderate		Inter Info	[79], [38], [31], [98], [298], [392], [393]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[402], [403], [404], [405], [406], [407]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[248], [91], [317], [318], [319], [320], [321]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[318], [320], [321]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[318], [320], [321]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[318], [320], [321]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[34], [295], [485]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[402], [403], [404], [405], [406], [407]
D1284		Phylloquinone	C31H46O2	5284607	Moderate		Inter Info	[501], [502], [503]
D1397		Ribavirin	C8H12N4O5	37542	Moderate		Inter Info	[505], [506], [507]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[38], [31], [295]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Minor		Inter Info	[214], [91], [548]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Minor		Inter Info	[214], [91], [548]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Minor		Inter Info	[214], [91], [548]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Minor		Inter Info	[214], [91], [548]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Minor		Inter Info	[214], [91], [548]
D0798		Indapamide	C16H16ClN3O3S	3702	Minor		Inter Info	[214], [91], [548]
D1048		Metolazone	C16H16ClN3O3S	4170	Minor		Inter Info	[214], [91], [548]
D1501		Spironolactone	C24H32O4S	5833	Minor		Inter Info	[34], [295], [563]
D1624		Trazodone	C19H22ClN5O	5533	Minor		Inter Info	[565], [566], [567]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[522], [523]

References
1	Product Information. Integrilin (eptifibatide). Schering Laboratories, Kenilworth, NJ.
2	Product Information. ReoPro (abciximab). Lilly, Eli and Company, Indianapolis, IN.
3	Barrow MV, Quick DT, Cunningham RW "Salicylate hypoprothrombinemia in rheumatoid arthritis with liver disease. Report of two cases." Arch Intern Med 120 (1967): 620-4. [PMID: 6054600]
4	Hirsch J, Dalen J, Guyatt G, American College of Chest Physicians "The sixth (2000) ACCP guidelines for antithrombotic therapy for prevention and treatment of thrombosis. American College of Physicians." Chest 119(1 Suppl) (2001): 1S-2S. [PMID: 11157638]
5	Weiss HJ, Aledort LM, Kochwa S "The effect of salicylates on the hemostatic properties of platelets in man." J Clin Invest 47 (1968): 2169-80. [PMID: 5675432]
6	Arora RR, Magun AM, Grossman M, Katz J "Cholesterol embolization syndrome after intravenous tissue plasminogen activator for acute myocardial infarction." Am Heart J 126 (1993): 225-8. [PMID: 8322670]
7	Gupta BK, Spinowitz BS, Charytan C, Wahl SJ "Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator." Am J Kidney Dis 21 (1993): 659-62. [PMID: 8503421]
8	Harder S, Klinkhardt U "Thrombolytics: drug interactions of clinical significance." Drug Saf 23 (2000): 391-9. [PMID: 11085346]
9	Julian DG "A comparison of aspirin and anticoagulation following thrombolysis for myocardial infarction (the AFTER study): a multicentre unblinded randomised clinical trial." BMJ 313 (1996): 1429-31. [PMID: 8973228]
10	Product Information. Abbokinase (urokinase). Abbott Pharmaceutical, Abbott Park, IL.
11	Product Information. Activase (alteplase). Genentech, South San Francisco, CA.
12	Product Information. Retavase (reteplase). Boehringer Mannheim, Gaithersburg, MD.
13	Product Information. Streptase (streptokinase). Astra USA, Westborough, MA.
14	Product Information. TNKase (tenecteplase) Genentech, South San Francisco, CA.
15	Caraco Y, Chajek-Shaul T "The incidence and clinical significance of amiodarone and acenocoumarol interaction." Thromb Haemost 62 (1989): 906-8. [PMID: 2595664]
16	Cheung B, Lam FM, Kumana CR "Lesson of the week: insidiously evolving, occult drug interaction involving warfarin and amiodarone." BMJ 312 (1996): 107-8. [PMID: 8555895]
17	Fondevila C, Meschengieser S, Lazzari M "Amiodarone-acenocoumarin interaction." Thromb Haemost 65 (1991): 328. [PMID: 1878066]
18	Gill J, Heel RC, Fitton A "Amiodarone: an overview of its pharmacological properties, and review of its therapeutic use in cardiac arrhythmias." Drugs 43 (1992): 69-110. [PMID: 1372862]
19	Hamer A, Peter T, Mandel WJ, et al "The potentiation of warfarin anticoagulation by amiodarone." Circulation 65 (1982): 1025-9. [PMID: 7074739]
20	Heimark LD, Wienkers L, Kunze K, et al "The mechanism of the interaction between amiodarone and warfarin in humans." Clin Pharmacol Ther 51 (1992): 398-407. [PMID: 1563209]
21	Jafari-Fesharaki M, Scheinman MM "Adverse effects of amiodarone." Pacing Clin Electrophysiol 21 (1998): 108-20. [PMID: 9474655]
22	Kerin NZ, Blevins RD, Goldman L, et al "The incidence, magnitude, and time course of the amiodarone-warfarin interaction." Arch Intern Med 148 (1988): 1779-81. [PMID: 3401099]
23	Neyroz P, Bonati M "In vitro amiodarone protein binding and its interaction with warfarin." Experientia 41 (1985): 361-3. [PMID: 3972082]
24	Serlin MJ, Sibeon RG, Breen GJ "Dangers of amiodarone and anticoagulant treatment." Br Med J (Clin Res Ed) 283 (1981): 58. [PMID: 6788267]
25	Shirolkar SC, Fiuzat M, Becker RC "Dronedarone and vitamin K antagonists: A review of drug-drug interactions." Am Heart J 160 (2010): 577-82. [PMID: 20934550]
26	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
27	Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83. [PMID: 7944078]
28	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
29	Antlitz AM, Tolentino M, Kosai MF "Effect of butabarbital on orally administered anticoagulants." Curr Ther Res Clin Exp 10 (1968): 70-3. [PMID: 4967727]
30	O'Reilly RA, Trager WF, Motley CH, Howald W "Interaction of secobarbital with warfarin pseudoracemates." Clin Pharmacol Ther 28 (1980): 187-95. [PMID: 7398186]
31	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
32	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
33	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
34	Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
35	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
36	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
37	Product Information. Kengreal (cangrelor). The Medicines Company, Parsippany, NJ.
38	Cerner Multum, Inc. "Australian Product Information.".
39	Product Information. Cablivi (caplacizumab). Genzyme Corporation, Cambridge, MA.
40	Ansell J, Hirsh J, Poller L, Bussey H, Jacobson A, Hylek E "The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy." Chest 126(3 Suppl) (2004): 204S-233S. [PMID: 15383473]
41	Bachmann K, Schwartz JI, Forney R Jr, Frogameni A, Jauregui LE "The effect of erythromycin on the disposition kinetics of warfarin." Pharmacology 28 (1984): 171-6. [PMID: 6718483]
42	Bartle WR "Possible warfarin-erythromycin interaction." Arch Intern Med 140 (1980): 985-7. [PMID: 7387311]
43	Gooderham MJ, Bolli P, Fernandez PG "Concomitant digoxin toxicity and warfarin interaction in a patient receiving clarithromycin." Ann Pharmacother 33 (1999): 796-9. [PMID: 10466907]
44	Grau E, Fontcuberta J, Felez J "Erythromycin-oral anticoagulants interaction." Arch Intern Med 146 (1986): 1639. [PMID: 3488045]
45	Grau E, Real E, Pastor E "Interaction between clarithromycin and oral anticoagulants." Ann Pharmacother 30 (1996): 1495-6. [PMID: 8968465]
46	Hassell D, Utt JK "Suspected interaction: warfarin and erythromycin." South Med J 78 (1985): 1015-6. [PMID: 4023774]
47	Husserl FE "Erythromycin-warfarin interaction." Arch Intern Med 143 (1983): 1831, 1836. [PMID: 6615113]
48	Kiran N, Azam S, Dhakam S "Clarithromycin induced digoxin toxicity: case report and review." J Pak Med Assoc 54 (2004): 440-1. [PMID: 15461217]
49	Loeliger EA, van der Esch B, Mattern MJ, Hemker HC "The biological disappearance rate of prothrombin, factors VII, IX and X from plasma in hypothyroidism, hyperthyroidism, and during fever." Thromb Diath Haemorrh 10 (1963): 267-77. [PMID: 14113369]
50	O'Donnell D "Antibiotic-induced potentiation of oral anticoagulant agents." Med J Aust 150 (1989): 163-4. [PMID: 2716588]
51	Recker MW, Kier KL "Potential interaction between clarithromycin and warfarin." Ann Pharmacother 31 (1997): 996-8. [PMID: 9296238]
52	Sato RI, Gray DR, Brown SE "Warfarin interaction with erythromycin." Arch Intern Med 144 (1984): 2413-4. [PMID: 6508448]
53	Schwartz J, Bachmann K, Perrigo E "Interaction between warfarin and erythromycin." South Med J 76 (1983): 91-3. [PMID: 6600525]
54	Visser LE, Penning-Van Bees FJ, Harrie Kasbergen AA, et al. "Overanticoagulation associated with combined use of antibacterial drugs and acenocoumarol or phenprocoumon anticoagulants." Thromb Haemost 88 (2002): 705-10. [PMID: 12428081]
55	Weibert RT, Lorentz SM, Townsend RJ, et al "Effect of erythromycin in patients receiving long-term warfarin therapy." Clin Pharm 8 (1989): 210-4. [PMID: 2706893]
56	Price AJ, Frcpath DO "Is there a clinical interaction between low molecular weight heparin and non-steroidal analgesics after total hip replacement?" Ann R Coll Surg Engl 77 (1995): 395. [PMID: 7486773]
57	Product Information. Arixtra (fondaparinux). Organon, West Orange, NJ.
58	Product Information. Fragmin (dalteparin). Pharmacia and Upjohn, Kalamazoo, MI.
59	Product Information. Innohep (tinzaparin) DuPont Pharmaceuticals, Wilmington, DE.
60	Product Information. Lovenox (enoxaparin). Rhone-Poulenc Rorer, Collegeville, PA.
61	Product Information. Normiflo (ardeparin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
62	Product Information. Orgaran (danaparoid). Organon, West Orange, NJ.
63	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
64	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
65	Product Information. Defitelio (defibrotide). Jazz Pharmaceuticals, Palo Alto, CA.
66	Product Information. Ipravask (desirudin). Aventis Pharmaceuticals, Swiftwater, PA.
67	Product Information. Savaysa (edoxaban). Daiichi Sankyo, Inc., Parsippany, NJ.
68	Adkins JC, Faulds D "Micronised fenofibrate: a review of its pharmacodynamic properties and clinical efficacy in the management of dyslipidaemia." Drugs 54 (1997): 615-33. [PMID: 9339964]
69	Ascah KJ, Rock GA, Wells PS "Interaction between fenofibrate and warfarin." Ann Pharmacother 32 (1998): 765-8. [PMID: 9681093]
70	Canadian Pharmacists Association.
71	Harvengt C, Heller F, Desager JP "Hypolipidemic and hypouricemic action of fenofibrate in various types of hyperlipoproteinemias." Artery 7 (1980): 73-82. [PMID: 7247733]
72	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online.".
73	Product Information. Lopid (gemfibrozil). Parke-Davis, Morris Plains, NJ.
74	Product Information. Tricor (fenofibrate). Abbott Pharmaceutical, Abbott Park, IL.
75	Product Information. Trilipix (fenofibric acid). Abbott Pharmaceutical, Abbott Park, IL.
76	Arnold LM, Nissen LR, Ng TM "Moxifloxacin and warfarin: additional evidence for a clinically relevant interaction." Pharmacotherapy 25 (2005): 904-7.[PMID: 15927911]
77	Glasheen JJ, Fugit RV, Prochazka AV "Effect of levofloxacin coadministration on the international normalized ratios during warfarin therapy--a comment." Pharmacotherapy 23 (2003): 1079-80 discussion 1080.[PMID: 12921255]
78	Bianco TM, Bussey HI, Farnett LE, Linn WD, Roush MK, Wong YW "Potential warfarin-ciprofloxacin interaction in patients receiving long-term anticoagulation." Pharmacotherapy 12 (1992): 435-9.[PMID: 1492006]
79	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
80	Cerner Multum, Inc. "Canadian Product Information.".
81	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
82	Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
83	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
84	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
85	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
86	Aggeler PM, O'Reilly RA "Effect of heptabarbital on the response to bishydroxycoumarin in man." J Lab Clin Med 74 (1969): 229-38. [PMID: 4184022]
87	Blouin R, Chaudhary I, Nishihara K, Cox S "The effects of liver and renal disease on stereoselective serum binding of flurbiprofen." Br J Clin Pharmacol 35 (1993): 62-4. [PMID: 8448071]
88	Cucinell SA, Conney AH, Sansur M, Burns JJ "Drug interactions in man. I: lowering effect of phenobarbital on plasma levels of bishydroxycoumarin (dicumarol) and diphenylhydantoin (dilantin)." Clin Pharmacol Ther 6 (1965): 420-9. [PMID: 14314964]
89	Elin RJ, Ruddel M, Korn WR, Thompson BC "Discrepant results for determination of theophylline in serum from a patient with renal failure ." Clin Chem 29 (1983): 1870. [PMID: 6616853]
90	Goss JE, Dickhaus DW "Increased bishydroxycoumarin requirements in patients receiving phenobarbital." N Engl J Med 273 (1965): 1094-5. [PMID: 4158082]
91	Ku LL, Ward CO, Durgin SJ "A clinical study of drug interaction and anticoagulant therapy." Drug Intell Clin Pharm 4 (1970): 300-6.
92	MacDonald MG, Robinson DS "Clinical observations of possible barbiturate interference with anticoagulation." JAMA 204 (1968): 97-100. [PMID: 5694725]
93	Clark NP, Hoang K, Delate T, Horn JR, Witt DM. Warfarin Interaction With Hepatic Cytochrome P-450 Enzyme-Inducing Anticonvulsants.?Clin Appl Thromb Hemost. 2018;24(1):172-178. [PMID: 28118749]
94	Scaroni C, Mazzoni PL, D'Amico E, Benvenuti C, Hind ID "Pharmacokinetics of oral and rectal flurbiprofen in children." Eur J Clin Pharmacol 27 (1984): 367-9. [PMID: 6510467]
95	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
96	Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
97	Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
98	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
99	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
100	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
101	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
102	Product Information. Kadcyla (ado-trastuzumab). Genentech, South San Francisco, CA.
103	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
104	Bates ER, Mukherjee D, Lau WC "Drug-drug interactions involving antiplatelet agents." Eur Heart J 24 (2003): 1707-9. [PMID: 14522564]
105	Brown PM, Hursting MJ "Lack of pharmacokinetic interactions between argatroban and warfarin." Am J Health Syst Pharm 59 (2002): 2078-83. [PMID: 12434720]
106	Product Information. Acova (argatroban) SmithKline Beecham, Philadelphia, PA.
107	Product Information. Refludan (lepirudin). Hoechst Marion-Roussel Inc, Kansas City, MO.
108	Product Information. Angiomax (bivalirudin) The Medicines Compny, Cambridge, MA.
109	Aki Z, Kotiloglu G, Ozyilkan O "A patient with a prolonged prothrombin time due to an adverse interaction between 5-fluorouracil and warfarin." Am J Gastroenterol 95 (2000): 1093-4.[PMID: 10763974]
110	Brown MC "An adverse interaction between warfarin and 5-fluorouracil: A case report and review of the literature." Chemotherapy 45 (1999): 392-5.[PMID: 10473927]
111	Brown MC "Multisite mucous membrane bleeding due to a possible interaction between warfarin and 5-flourouracil." Pharmacotherapy 17 (1997): 631-3.[PMID: 9165571]
112	Anand S, Yusuf S, Xie C, et al. "Oral anticoagulant and antiplatelet therapy and peripheral arterial disease." N Engl J Med 357 (2007): 217-27. [PMID: 17634457]
113	Buresly K, Eisenberg MJ, Zhang X, Pilote L "Bleeding complications associated with combinations of aspirin, thienopyridine derivatives, and warfarin in elderly patients following acute myocardial infarction." Arch Intern Med 165 (2005): 784-9. [PMID: 15824298]
114	Delaney JA, Opatrny L, Brophy JM, Suissa S "Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding." CMAJ 177 (2007): 347-51. [PMID: 17698822]
115	Eikelboom JW, Hirsh J "Combined antiplatelet and anticoagulant therapy: clinical benefits and risks." J Thromb Haemost 5 (2007): 255-63. [PMID: 17635734]
116	Hermosillo AJ, Spinler SA "Aspirin, clopidogrel, and warfarin: is the combination appropriate and effective or inappropriate and too danterous?" Ann Pharmacother 42 (2008): 790-805. [PMID: 18477734]
117	Johnson SG, Rogers K, Delate T, Witt DM "Outcomes associated with combined antiplatelet and anticoagulant therapy." Chest 133 (2008): 948-54. [PMID: 18198244]
118	Lidell C, Svedberg LE, Lindell P, Bandh S, Job B, Wallentin L "Clopidogrel and warfarin: absence of interaction in patients receiving long-term anticoagulant therapy for non-valvular atrial fibrillation." Thromb Haemost 89 (2003): 842-6. [PMID: 12719782]
119	Product Information. Plavix (clopidogrel). Bristol-Myers Squibb, Princeton, NJ.
120	Tay KH, Lane DA, Lip GY "Bleeding risks with combination of oral anticoagulation plus antiplatelet therapy: is clopidogrel any safer than aspirin when combined with warfarin?" Thromb Haemost 100 (2008): 955-7. [PMID: 19132214]
121	Penning-van Beest F, Erkens J, Petersen KU, Koelz HR, Herings R "Main comedications associated with major bleeding during anticoagulant therapy with coumarins." Eur J Clin Pharmacol 61 (2005): 439-44. [PMID: 15947920]
122	Loftin JP, Vesell ES "Interaction between sulindac and warfarin: different results in normal subjects and in an unusual patient with a potassium-losing renal tubular defect." J Clin Pharmacol 19 (1979): 733-42.[PMID: 536470]
123	Gabb GM "Fatal outcome of interaction between warfarin and a non-steroidal anti-inflammatory drug." Med J Aust 164 (1996): 700-1.[PMID: 8657040]
124	Product Information. Xigris (drotrecogin alfa). Lilly, Eli and Company, Indianapolis, IN.
125	Baciewicz AM, Menke JJ, Bokar JA, Baud EB "Fluconazole-warfarin interaction." Ann Pharmacother 28 (1994): 1111. [PMID: 7803894]
126	Black DJ, Kunze KL, Wienkers LC, et al "Warfarin-fluconazole. II. A metabolically based drug interaction: in vivo studies." Drug Metab Dispos 24 (1996): 422-8. [PMID: 8801057]
127	Crussell-Porter LL, Rindone JP, Ford MA, Jaskar DW "Low-dose fluconazole therapy potentiates the hypoprothrombinemic response of warfarin sodium." Arch Intern Med 153 (1993): 102-4. [PMID: 8422191]
128	Grant SM, Clissold SP "Fluconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses." Drugs 39 (1990): 877-916. [PMID: 2196167]
129	Holechek MJ "Medication review: fluconazole." ANNA J 18 (1991): 585-6. [PMID: 1750792]
130	Kerr HD "Case report: potentiation of warfarin by fluconazole." Am J Med Sci 305 (1993): 164-5. [PMID: 8447335]
131	Kunze KL, Wienkers LC, Thummel KE, Trager WF "Warfarin-fluconazole. I. Inhibition of the human cytochrome p450-dependent metabolism of warfarin by fluconazole: in vitro studies." Drug Metab Dispos 24 (1996): 414-21. [PMID: 8801056]
132	Lazar JD, Wilner KD "Drug interactions with fluconazole." Rev Infect Dis 12 Suppl 3 (1990): s327-33. [PMID: 2330488]
133	Miners JO, Birkett DJ "Cytochrome P4502C9: an enzyme of major importance in human drug metabolism." Br J Clin Pharmacol 45 (1998): 525-38. [PMID: 9663807]
134	Mootha VV, Schluter ML, Das A "Intraocular hemorrhages due to warfarin fluconazole drug interaction in a patient with presumed Candida endophthalmitis." Arch Ophthalmol 120 (2002): 94-5. [PMID: 11786068]
135	Morrow JD "Fluconazole: a new triazole antifungal agent." Am J Med Sci 302 (1991): 129-32. [PMID: 1897559]
136	Pea F, Furlanut M "Pharmacokinetic aspects of treating infections in the intensive care unit: focus on drug interactions." Clin Pharmacokinet 40 (2001): 833-868. [PMID: 11735605]
137	Seaton TL, Celum CL, Black DJ "Possible potentiation of warfarin by fluconazole." Ann Pharmacother 24 (1990): 1177-8. [PMID: 2089826]
138	Tett S, Carey D, Lee H-S "Drug interactions with fluconazole." Med J Aust 156 (1992): 365. [PMID: 1588879]
139	Venkatakrishnan K, vonMoltke LL, Greenblatt DJ "Effects of the antifungal agents on oxidative drug metabolism - Clinical relevance." Clin Pharmacokinet 38 (2000): 111-80. [PMID: 10709776]
140	Product Information. Coumadin (warfarin). DuPont Pharmaceuticals, Wilmington, DE.
141	Product Information. Heparin Sodium (heparin). Lilly, Eli and Company, Indianapolis, IN.
142	Product Information. In-111 Zevalin (ibritumomab). IDEC Pharmaceuticals Corporation, San Diego, CA.
143	Dean RP, Talbert RL "Bleeding associated with concurrent warfarin and metronidazole therapy." Drug Intell Clin Pharm 14 (1980): 864-6.
144	Hermans JJ, Thijssen HH "Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics." Br J Pharmacol 110 (1993): 482-90. [PMID: 8220911]
145	Hermida J, Zarza J, Alberca I, et al. "Differential effects of 2C93 and 2C92 variants of cytochrome P-450 CYP2C9 on sensitivity to acenocoumarol." Blood 99 (2002): 4237-9. [PMID: 12010835]
146	Kazmier FJ "A significant interaction between metronidazole and warfarin." Mayo Clin Proc 51 (1976): 782-4. [PMID: 994556]
147	Kelly JG, O'Malley K "Clinical pharmacokinetics of oral anticoagulants." Clin Pharmacokinet 4 (1979): 1-15. [PMID: 369763]
148	O'Reilly RA "The stereoselective interaction of warfarin and metronidazole in man." N Engl J Med 295 (1976): 354-7. [PMID: 934223]
149	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
150	Serlin MJ, Breckenridge AM "Drug interactions with warfarin." Drugs 25 (1983): 610-20. [PMID: 6347619]
151	Takahashi H, Wilkinson GR, Caraco Y, et al. "Population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients." Clin Pharmacol Ther 73 (2003): 253-63. [PMID: 12621390]
152	Thijssen HH, Flinois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Disposition 28 (2000): 1284-90. [PMID: 11038154]
153	Laine K, Forsstrom J, Gronroos P, Irjala K, Kailajarvi M, Scheinin M "Frequency and clinical outcome of potentially harmful drug metabolic interactions in patients hospitalized on internal and pulmonary medicine wards: Focus on warfarin and cisapride." Ther Drug Monit 22 (2000): 503-9. [PMID: 11034253]
154	Ariyaratnam S, Thakker NS, Sloan P, Thornhill MH "Potentiation of warfarin anticoagulant activity by miconazole oral gel." BMJ 314 (1997): 349. [PMID: 9040331]
155	Colquhoun MC, Daly M, Stewart P, Beeley L "Interaction between warfarin and miconazole oral gel." Lancet 1 (1987): 695-6. [PMID: 2882124]
156	Devaraj A, O'Beirne JP, Veasey R, Dunk AA "Interaction between warfarin and topical miconazole cream." BMJ 325 (2002): 77. [PMID: 12114237]
157	Evans J, Orme DS, Sedgwick ML, Youngs GR "Treating oral candidiasis: potentially fatal." Br Dent J 182 (1997): 452. [PMID: 9231515]
158	Gutierrez MA, Olalla I, Muruzabal MJ, Ortiz M, Peralta FG "Miconazole oral gel enhances acenocoumarol anticoagulant activity. Report of three cases." Eur J Clin Pharmacol 52(Suppl) (1997): A132. [PMID: 10084413]
159	Marco M "Retroperitoneal haematoma and small bowel intramural haematoma caused by warfarin and miconazole interaction." Int J Oral Maxillofac Surg 27 (1998): 485. [PMID: 9869294]
160	Niwa T, Shiraga T, Takagi A "Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, CYP3A4 activities in human liver microsomes." Biol Pharm Bull 28 (2005): 1805-8. [PMID: 16141567]
161	O'Reilly RA, Goulart DA, Kunze KL, et al "Mechanisms of the stereoselective interaction between miconazole and racemic warfarin in human subjects." Clin Pharmacol Ther 51 (1992): 656-67. [PMID: 1611805]
162	Ortin M, Olalla JI, Muruzabal MJ, Peralta FG, Gutierrez MA "Miconazole oral gel enhances acenocoumarol anticoagulant activity: A report of three cases." Ann Pharmacother 33 (1999): 175-7. [PMID: 10084413]
163	Pemberton M, Sloan P, Ariyaratnam S, Thakker NS, Thornhill MH "Treating oral candidiasis: potentially fatal." Br Dent J 183 (1997): 87. [PMID: 9282448]
164	Pemberton MN, Sloan P, Ariyaratnam S, Thakker NS, Thornhill MH "Derangement of warfarin anticoagulation by miconazole oral gel." Br Dent J 184 (1998): 68-9. [PMID: 9489213]
165	Shenfield GM, Page M "Potentiation of warfarin action by miconazole oral gel." Aust N Z J Med 21 (1991): 928. [PMID: 1818557]
166	Thirion DJ, Farquhar Zannetti LA "Potentiation of warfarin's hypoprothrombinemic effect with miconazole vaginal suppositories." Pharmacotherapy 20 (2000): 98-9. [PMID: 10641982]
167	Visser LE, Penning-Van Beest FJ, Kasbergen AA, et al. "Overanticoagulation associated with combined use of antifungal agents and coumarin anticoagulants." Clin Pharmacol Ther 71 (2002): 496-502. [PMID: 12087353]
168	Watson PG, Lochan RG, Redding VJ "Drug interaction with coumarin derivative anticoagulants." Br Med J 285 (1982): 1045-6. [PMID: 6812734]
169	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
170	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
171	Rifampin.?Tuberculosis (Edinb). 2008;88(2):151-154. doi:10.1016/S1472-9792(08)70024-6. [PMID: 18486058]
172	Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6. [PMID: 1558427]
173	Casner PR "Inability to attain oral anticoagulation: warfarin-rifampin interaction revisited." South Med J 89 (1996): 1200-3. [PMID: 8969357]
174	Heimark LD, Gibaldi M, Trager WF, et al "The mechanism of the warfarin-rifampin drug interaction in humans." Clin Pharmacol Ther 42 (1987): 388-94. [PMID: 3665337]
175	Heimark LD, Gilbaldi M, Trager WF, et al "The mechanism of the warfarin-rifampin drug interaction in humans." Clin Pharmacol Ther 42 (1987): 388-94. [PMID: 3665337]
176	O'Reilly RA "Interaction of chronic daily warfarin therapy and rifampin." Ann Intern Med 83 (1975): 506-8. [PMID: 1166982]
177	O'Reilly RA "Interaction of sodium warfarin and rifampin." Ann Intern Med 81 (1974): 337-40. [PMID: 4852505]
178	Self TH, Mann RB "Interaction of rifampin and warfarin." Chest 4 (1975): 490-1. [PMID: 1122784]
179	Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8. [PMID: 9385296]
180	Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65. [PMID: 1559307]
181	Cook DE, Ponte CD "Suspected trimethoprim sulfamethoxazole induced hypoprothrombinemia." J Fam Pract 39 (1994): 589-91. [PMID: 7798864]
182	Fischer HD, Juurlink DN, Mamdani MM, Kopp A, Laupacis A "Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based study." Arch Intern Med 170 (2010): 617-21. [PMID: 20386005]
183	Glasheen JJ, Fugit RV, Prochazka AV "The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens." J Gen Intern Med 20 (2005): 653-6. [PMID: 16050864]
184	Lumholtz B, Siersbaek-Nielsen K, Skovsted L, Kampmann J, Hansen JM "Sulfamethizole-induced inhibition of diphenylhydantoin, tolbutamide, and warfarin metabolism." Clin Pharmacol Ther 17 (1975): 731-4. [PMID: 1139863]
185	O'Reilly RA "Stereoselective interaction of trimethoprim-sulfamethaxazole with the separated enantiomorphs of racemic warfarin in man." N Engl J Med 302 (1980): 33-5. [PMID: 7350395]
186	O'Reilly RA, Motley CH "Racemic warfarin and trimethoprim-sulfamethoxazole interaction in humans." Ann Intern Med 91 (1979): 34-6. [PMID: 464451]
187	Penning-van Beest FJ, van Meegen E, Rosendaal FR, Stricker BH "Drug interactions as a cause of overanticoagulation on phenprocoumon or acenocoumarol predominantly concern antibacterial drugs." Clin Pharmacol Ther 69 (2001): 451-7. [PMID: 11406743]
188	Self TH, Evans W, Ferguson T "Interaction of sulfisoxizole and warfarin." Circulation 52 (1975): 528. [PMID: 1157265]
189	Sioris LJ, Weibert RT, Pentel PR "Potentiation of warfarin anaticoagulation by sulfisoxazole." Arch Intern Med 140 (1980): 546-7. [PMID: 7362390]
190	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
191	Product Information. Nolvadex (tamoxifen). Zeneca Pharmaceuticals, Wilmington, DE.
192	Ritchie LD, Grant SM "Tamoxifen-warfarin interaction: the Aberdeen hospitals drug file." BMJ 298 (1989): 1253. [PMID: 2502242]
193	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
194	Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab). GlaxoSmithKline, Research Triangle Park, NC.
195	Product Information. BexxarTherapy (tositumomab). GlaxoSmithKline Inc, Oakville, IA.
196	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
197	Purkins L, Wood N, Kleinermans D, Nichols D "Voriconazole potentiates warfarin-induced prothrombin time prolongation." Br J Clin Pharmacol 56 Suppl 1 (2003): 24-9. [PMID: 14616410]
198	Antlitz AM, Mead JA Jr, Tolentino MA "Potentiation of oral anticoagulant therapy by acetaminophen." Curr Ther Res Clin Exp 10 (1968): 501-7. [PMID: 4971464]
199	Bagheri H, Bernhard NB, Montastruc JL "Potentiation of the acenocoumarol anticoagulant effect by acetaminophen." Ann Pharmacother 33 (1999): 506. [PMID: 10332548]
200	Bell RB "Acetaminophen and warfarin: undesirable synergy." JAMA 279 (1998): 702-3. [PMID: 9496990]
201	Boeijinga JJ, Boerstra EE, Ris P, Breimer DD, Jeletich-Bastiaanse A "Interaction between paracetamol and coumarin anticoagulants." Lancet 1 (1982): 506. [PMID: 6121161]
202	Gebauer MG, Nyfort-Hansen K, Henschke PJ, Gallus AS "Warfarin and acetaminophen interaction." Pharmacotherapy 23 (2003): 109-12. [PMID: 12523469]
203	Hylek EM, Heiman H, Skates SJ, Sheehan MA, Singer DE "Acetaminophen and other risk factors for excessive warfarin anticoagulation." JAMA 279 (1998): 657-62. [PMID: 9496982]
204	Kwan D, Bartle WR, Walker SE "The effects of acetaminophen on pharmacokinetics and pharmacodynamics of warfarin." J Clin Pharmacol 39 (1999): 68-75. [PMID: 9987702]
205	Shek KL, Chan LN, Nutescu E "Warfarin-acetaminophen drug interaction revisited." Pharmacotherapy 19 (1999): 1153-8. [PMID: 10512064]
206	Singer DE, Skates SJ "Acetaminophen and risk factors for excess anticoagulation with warfarin." JAMA 281 (1999): 37. [PMID: 9728633]
207	Fattinger K, Frisullo R, Masche U, Braunschweig S, Meier PJ, Roos M "No clinically relevant drug interaction between paracetamol and phenprocoumon based on a pharmacoepidemiological cohort study in medical inpatients." Eur J Clin Pharmacol 57 (2002): 863-7. [PMID: 11936705]
208	Lowenthal DT "The treatment of hyperuricemia." Am Fam Physician 14 (1976): 98-100. [PMID: 937167]
209	McInnes GT, Lawson DH, Jick H "Acute adverse reactions attributed to allopurinol in hospitalised patients." Ann Rheum Dis 40 (1981): 245-9. [PMID: 7247470]
210	Pond SM, Graham GG, Wade DN, Sudlow G "The effects of allopurinol and clofibrate on the elimination of coumarin anticoagulants in man." Aust N Z J Med 5 (1975): 324-8. [PMID: 52353]
211	Rawlins MD, Smith SE "Influence of allopurinol on drug metabolism in man." Br J Clin Pharmacol 48 (1973): 693-8. [PMID: 4788211]
212	Self TH, Evans WE, Ferguson T "Drug enhancement of warfarin activity." Lancet 2 (1975): 557-8. [PMID: 51384]
213	Vesell ES, Passananti GT, Greene FE "Impairment of drug metabolism in man by allopurinol and nortriptyline." N Engl J Med 283 (1970): 1484-8. [PMID: 4098480]
214	Koch-Weser J, Sellers EM "Drug interactions with coumarin anticoagulants (first of two parts)." N Engl J Med 285 (1971): 487-98. [PMID: 4397794]
215	Pond SM, Graham GG, Birkett DJ, Wade DN "Effects of tricyclic antidepressants on drug metabolism." Clin Pharmacol Ther 18 (1975): 191-9
216	Alexander DP, Russo ME, Fohrman DE, Rothstein G "Nafcillin-induced platelet dysfunction and bleeding." Antimicrob Agents Chemother 23 (1983): 59-62. [PMID: 6830209]
217	Andrassy K, Ritz E, Hasper B, Scherz M, Walter E, Storch H "Penicillin-induced coagulation disorder." Lancet 2 (1976): 1039-41. [PMID: 62897]
218	Andrassy K, Ritz E, Weisschedel E "Bleeding after carbenicillin administration." N Engl J Med 292 (1975): 109. [PMID: 1109431]
219	Bandrowsky T, Vorono AA, Borris TJ, Marcantoni HW "Amoxicillin-related postextraction bleeding in an anticoagulated patient with tranexamic acid rinses." Oral Surg Oral Med Oral Pathol 82 (1996): 610-2. [PMID: 8974131]
220	Brown CH 3d, Bradshaw MJ, Natelson EA, Alfrey CP Jr, Williams TW Jr "Defective platelet function following the administration of penicillin compounds." Blood 47 (1976): 949-56. [PMID: 1276476]
221	Brown CH 3d, Natelson EA, Bradshaw MW, Alfrey CP Jr, Williams TW Jr "Study of the effects of ticarcillin on blood coagulation and platelet function." Antimicrob Agents Chemother 7 (1975): 652-7. [PMID: 1147594]
222	Brown CH 3d, Natelson EA, Bradshaw W, Williams TW Jr, Alfrey CP Jr "The hemostatic defect produced by carbenicillin." N Engl J Med 291 (1974): 265-70. [PMID: 4407110]
223	Davydov L, Yermolnik M, Cuni LJ "Warfarin and amoxicillin/clavulanate drug interaction." Ann Pharmacother 37 (2003): 367-370. [PMID: 12639164]
224	Gentry LO, Jemsek JG, Natelson EA "Effects of sodium piperacillin on platelet function in normal volunteers." Antimicrob Agents Chemother 19 (1981): 532-3. [PMID: 6454385]
225	Kelly M, Moran J, Byrne S "Formation of rectus sheath hematoma with antibiotic use and warfarin therapy: a case report." Am J Geriatr Pharmacother 3 (2005): 266-9. [PMID: 16503323]
226	Larsen TR, Gelaye A, Durando C "Acute warfarin toxicity: an unanticipated consequence of amoxicillin/clavulanate administration." Am J Case Rep 15 (2014): 45-8. [PMID: 24494060]
227	Rice PJ, Perry RJ, Afzal Z, Stockley IH "Antibacterial prescribing and warfarin: a review." Br Dent J 194 (2003): 411-5. [PMID: 12778089]
228	Wood GD "Antibiotic prescribing and warfarin enhancement." Br Dent J 175 (1993): 241. [PMID: 8398465]
229	Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
230	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
231	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
232	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
233	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil at steady state on the single-dose pharmacokinetic profile of warfarin in healthy volunteers." J Clin Pharmacol 42 (2002): 205-14. [PMID: 11831544]
234	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]
235	Caruso V, Iacoviello L, Di Castelnuovo A, et.al "Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients." Blood 108 (2006): 2216-22. [PMID: 16804111]
236	Duarte X, Esteves S, Neto AM, Pereira F "Incidence and risk factors for central nervous system thrombosis in paediatric acute lymphoblastic leukaemia during intensive asparaginase treatment: a single-centre study." Br J Haematol 174 (2016): 280-91. [PMID: 27018199]
237	Elice F, Rodeghiero F "Hematologic malignancies and thrombosis." Thromb Res 129 (2012): 360-6. [PMID: 22197450]
238	Grace RF, DeAngelo DJ, Stevenson KE, et.al "The use of prophylactic anticoagulation during induction and consolidation chemotherapy in adults with acute lymphoblastic leukemia." J Thromb Thrombolysis 45 (2018): 306-14. [PMID: 29260426]
239	Kieslich M, Porto L, Lanfermann H, Jacobi G, Schwabe D, Bohles H "Cerebrovascular complications of L-asparaginase in the therapy of acute lymphoblastic leukemia." J Pediatr Hematol Oncol 25 (2003): 484-7. [PMID: 12794528]
240	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
241	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
242	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
243	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
244	Truelove E, Fielding AK, Hunt BJ "The coagulopathy and thrombotic risk associated with L-asparaginase treatment in adults with acute lymphoblastic leukaemia." Leukemia 27 (2013): 553-9. [PMID: 23099335]
245	Mitchell L, Andrew M, Hanna K, et.al "Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l-asparaginase for acute lymphoblastic leukemia. Results of the PAARKA study." Thromb Haemost 90 (2003): 235-44. [PMID: 12888870]
246	Richards JR, Garber D, Laurin EG, et al. Treatment of cocaine cardiovascular toxicity: a systematic review.?Clin Toxicol (Phila). 2016;54(5):345-364. [PMID: 26919414]
247	Fausa O "Salicylate-induced hypoprothrombinemia: a report of four cases." Acta Med Scand 188 (1970): 403-8. [PMID: 5490567]
248	Koch-Weser J, Sellers EM "Drug interactions with coumarin anticoagulants (second of two parts)." N Engl J Med 285 (1971): 547-58. [PMID: 4397794]
249	Product Information. Suprax (cefixime). Lupin Pharmaceuticals Inc, Baltimore, MD.
250	Wood T, Johnson K, Naylor S, Weinshilboum R "Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in humantissue: possible relationship to hypoprothrombinemia." Drug Metab Dispos 30 (2002): 1123-1128
251	Natelson EA, Brown CH, 3d Bradshaw MW, Alfrey CP, Jr Williams TW, Jr "Influence of cephalosporin antibiotics on blood coagulation and platelet function." Antimicrob Agents Chemother 9 (1976): 91-3
252	Product Information. Chenodal (chenodeoxycholic acid). Manchester Pharmaceutical, Fort Collins, CO.
253	Gross L, Brotman M "Hypoprothrombinemia and hemorrhage associated with cholestyramine therapy." Ann Intern Med 72 (1970): 95-6. [PMID: 5410402]
254	Longstreth GF, Newcomer AD "Drug-induced malabsorption." Mayo Clin Proc 50 (1975): 284-93. [PMID: 1127993]
255	Product Information. Questran (cholestyramine). Par Pharmaceutical Inc, Chestnut Ridge, NY.
256	Robinson DS, Benjamin DM, McCormack JJ "Interaction of warfarin and nonsystemic gastrointestinal drugs." Clin Pharmacol Ther 12 (1971): 491-5. [PMID: 5567801]
257	Alderman CP, Moritz CK, Ben-Tovim DI "Abnormal platelet aggregation associated with fluoxetine therapy." Ann Pharmacother 26 (1992): 1517-9. [PMID: 1482806]
258	Alderman CP, Seshadri P, Ben-Tovim DI "Effects of serotonin reuptake inhibitors on hemostasis." Ann Pharmacother 30 (1996): 1232-4. [PMID: 8913401]
259	Aranth J, Lindberg C "Bleeding, a side effect of fluoxetine." Am J Psychiatry 149 (1992): 412. [PMID: 1536285]
260	Bannister SJ, Houser VP, Hulse JD, Kisicki JC, Rasmussen JG "Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin." Acta Psychiatr Scand Suppl 350 (1989): 102-6. [PMID: 2530759]
261	Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions. II." J Clin Psychopharmacol 10 (1990): 213-7. [PMID: 2198298]
262	Claire RJ, Servis ME, Cram DL Jr "Potential interaction between warfarin sodium and fluoxetine." Am J Psychiatry 148 (1991): 1604. [PMID: 1928485]
263	Dalton SO, Johansen C, Mellemkjaer L, Norgard B, Sorensen HT, Olsen JH "Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study." Arch Intern Med 163 (2003): 59-64. [PMID: 12523917]
264	de Abajo FJ, Jick H, Derby L, Jick S, Schmitz S "Intracranial haemorrhage and use of selective serotonin reuptake inhibitors." Br J Clin Pharmacol 50 (2000): 43-7. [PMID: 10886117]
265	de Abajo FJ, Rodriguez LA, Montero D "Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study." BMJ 319 (1999): 1106-9. [PMID: 10531103]
266	de Maistre E, Allart C, Lecompte T, Bollaert PE "Severe bleeding associated with use of low molecular weight heparin and selective serotonin reuptake inhibitors." Am J Med 113 (2002): 530-2. [PMID: 12427509]
267	Dent LA, Orrock MW "Warfarin-fluoxetine and diazepam-fluoxetine interaction." Pharmacotherapy 17 (1997): 170-2. [PMID: 9017779]
268	Ford MA, Anderson ML, Rindone JP, Jaskar DW "Lack of effect of fluoxetine on the hypoprothrombinemic response of warfarin." J Clin Psychopharmacol 17 (1997): 110-2. [PMID: 10950474]
269	Hergovich N, Aigner M, Eichler HG, Entlicher J, Drucker C, Jilma B "Paroxetine decreases platelet serotonin storage and platelet function in human beings." Clin Pharmacol Ther 68 (2000): 435-42. [PMID: 11061584]
270	Humphries JE, Wheby MS, VandenBerg SR "Fluoxetine and the bleeding time." Arch Pathol Lab Med 114 (1990): 727-8. [PMID: 2363631]
271	Krivy J, Wiener J "Sertraline and platelet counts in idiopathic thrombocytopenia purpura." Lancet 345 (1995): 132. [PMID: 7815874]
272	Leung M, Shore R "Fluvoxamine-associated bleeding." Can J Psychiatry 41 (1996): 604-5. [PMID: 8946088]
273	Messiha FS "Fluoxetine - adverse effects and drug-drug interactions." J Toxicol Clin Toxicol 31 (1993): 603-30. [PMID: 8254702]
274	Ottervanger JP, Stricker BH, Huls J, Weeda JN "Bleeding attributed to the intake of paroxetine." Am J Psychiatry 151 (1994): 781-2. [PMID: 8166328]
275	Pai VB, Kelly MW "Bruising associated with the use of fluoxetine." Ann Pharmacother 30 (1996): 786-8. [PMID: 8826562]
276	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
277	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
278	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
279	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
280	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
281	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
282	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
283	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
284	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
285	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
286	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
287	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
288	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
289	Settle EC "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry 59 Suppl 16 (1998): 25-30. [PMID: 9796863]
290	Skop BP, Brown TM "Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors." Psychosomatics 37 (1996): 12-6. [PMID: 8600488]
291	Woolfrey S, Gammack NS, Dewar MS, Brown PJ "Fluoxetine-warfarin interaction." BMJ 307 (1993): 241. [PMID: 8369688]
292	Yaryura-Tobias JA, Kirschen H, Ninan P, Mosberg HJ "Fluoxetine and bleeding in obsessive-compulsive disorder." Am J Psychiatry 148 (1991): 949. [PMID: 2053641]
293	Layton D, Clark DWJ, Pearce GL, Shakir SAW "Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England." Eur J Clin Pharmacol 57 (2001): 167-76. [PMID: 11417450]
294	Tata LJ, Fortun PJ, Hubbard RB, et al. "Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding?" Aliment Pharmacol Ther 22 (2005): 175-81. [PMID: 16091054]
295	Guo LQ, Yamazoe Y "Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines." Acta Pharmacol Sin 25 (2004): 129-36. [PMID: 14769198]
296	Hall G, Lind MJ, Huang M, Moore A, Gane A, Roberts JT, Cantwell BM "Intravenous infusions of ifosfamide/mesna and perturbation of warfarin anticoagulant control." Postgrad Med J 66 (1990): 860-1. [PMID: 2129174]
297	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
298	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
299	Product Information. Kybella (deoxycholic acid). Kythera Biopharmaceuticals, Inc., Westlake Village, CA.
300	Ahmad S "Omeprazole-warfarin interaction." South Med J 84 (1991): 674-5. [PMID: 2035104]
301	Andersson T, HassanAlin M, Hasselgren G, Rohss K "Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole." Clin Pharmacokinet 40 (2001): 523-37. [PMID: 11510629]
302	Product Information. Aciphex (rabeprazole) Janssen Pharmaceuticals, Titusville, NJ.
303	Product Information. Dexilant (dexlansoprazole). Takeda Pharmaceuticals America, Lincolnshire, IL.
304	Product Information. Nexium (esomeprazole) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
305	Product Information. Omeprazole (omeprazole). Mylan Pharmaceuticals Inc, Morgantown, WV.
306	Product Information. Prevacid (lansoprazole). TAP Pharmaceuticals Inc, Deerfield, IL.
307	Product Information. Protonix (pantoprazole) Wyeth-Ayerst Laboratories, Philadelphia, PA.
308	Steinijans VW, Huber R, Hartmann M, Zech K, Bliesath H, Wurst W, Radtke HW "Lack of pantoprazole drug interactions in man." Int J Clin Pharmacol Ther 32 (1994): 385-99. [PMID: 7981922]
309	Steinijans VW, Huber R, Hartmann M, Zech K, Bliesath H, Wurst W, Radtke HW "Lack of pantoprazole drug interactions in man: an updated review." Int J Clin Pharmacol Ther 34 (1 suppl) (1996): s31-50. [PMID: 8793602]
310	Steinijans VW, Huber R, Hartmann M, Zech K, Bliesath H, Wurst W, Radtke HW "Lack of pantoprazole drug interactions in man: an updated review." Int J Clin Pharmacol Ther 34 (1996): 243-62. [PMID: 8793611]
311	Sutfin T, Blamer K, Bostrom H, Eriksson S, Hoglund P, Paulsen O "Stereoselective interaction of omeprazole with warfarin in healthy men." Ther Drug Monit 11 (1989): 176-84. [PMID: 2718223]
312	Unge P, Svedberg LE, Nordgren A, et al. "A study of the interaction of omeprazole and warfarin in anticoagulated patients." Br J Clin Pharmacol 34 (1992): 509-12. [PMID: 1493083]
313	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
314	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
315	Product Information. Ventavis (iloprost). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
316	Product Information. Aptiom (eslicarbazepine). Sunovion Pharmaceuticals Inc, Marlborough, MA.
317	Meade TW "Oral contraceptives, clotting factors, and thrombosis." Am J Obstet Gynecol 142 (1982): 758-61. [PMID: 6801980]
318	Notelovitz M "Oral contraception and coagulation." Clin Obstet Gynecol 28 (1985): 73-83. [PMID: 3987135]
319	Schrogie JJ, Solomon HM, Zieve PD "Effect of oral contraceptives on vitamin K-dependent clotting activity." Clin Pharmacol Ther 8 (1967): 670-5. [PMID: 4167917]
320	Stangel JJ, Innerfield I, Reyniak JV, Stone ML "The effect of conjugated estrogens on coagulability in menopausal women." Obstet Gynecol 49 (1977): 314-6. [PMID: 190571]
321	von Kaulla E, Droegemueller W, von Kaulla KN "Conjugated estrogens and hypercoagulability." Am J Obstet Gynecol 122 (1975): 688-92. [PMID: 15850603]
322	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
323	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
324	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
325	Scordo MG, Pengo V, Spina E, Dahl ML, Gusella M, Padrini R "Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance." Clin Pharmacol Ther 72 (2002): 702-710. [PMID: 12496751]
326	Hansen JM, Siersboek-Nielsen K, Skovsted L "Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man." Clin Pharmacol Ther 12 (1971): 539-43. [PMID: 5567804]
327	Levine M, Sheppard I "Biphasic interaction of phenytoin with warfarin." Clin Pharm 3 (1984): 200-3. [PMID: 6723231]
328	Nappi JM "Warfarin and phenytoin interaction." Ann Intern Med 90 (1979): 852. [PMID: 434697]
329	Skovsted L, Kristensen M, Hansen M, Siersboek-Nielsen K "The effect of different oral anticoagulants on diphenylhydantoin (DPH) and tolbutamide metabolism." Acta Med Scand 199 (1976): 513-5. [PMID: 59517]
330	Burnham BE "Garlic as a possible risk for postoperative bleeding." Plast Reconstr Surg 95 (1995): 213. [PMID: 7809259]
331	Chutani SK, Bordia A "The effect of fried versus raw garlic on fibrinolytic activity in man." Atherosclerosis 38 (1981): 417-21. [PMID: 7225179]
332	Evans V "Herbs and the brain: friend or foe? The effects of ginkgo and garlic on warfarin use." J Neurosci Nurs 32 (2000): 229-32. [PMID: 10994537]
333	Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8. [PMID: 10675182]
334	German K, Kumar U, Blackford HN "Garlic and the risk of TURP bleeding." Br J Urol 76 (1996): 518. [PMID: 7551902]
335	Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
336	Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
337	Kiesewetter H, Jung F, Jung EM, Mrowietz C, Kosciehlny J, Wenzel E "Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack." Eur J Clin Pharmacol 45 (1993): 333-6. [PMID: 8299665]
338	Legnani C, Frascaro M, Guazzaloca G, Ludovici S, Cesarano G, Coccheri S "Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects." Arzneimittelforschung 43 (1993): 119-22. [PMID: 8457236]
339	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
340	Morris J, Burke V, Mori TA, Vandongen R, Beilin LJ "Effects of garlic extract on platelet aggregation: a randomized placebo-controlled double-blind study." Clin Exp Pharmacol Physiol 22 (1995): 414-7. [PMID: 8582091]
341	Steiner M, Lin RS "Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract." J Cardiovasc Pharmacol 31 (1998): 904-8. [PMID: 9641475]
342	Vaes LP, Chyka PA "Interactions of warfarin with garlic, ginger, or ginseng: nature of evidence." Ann Pharmacother 34 (2000): 1478-82. [PMID: 11144706]
343	Apitz-Castro R, Escalante J, Vargas R, Jain MK "Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets." Thromb Res 42 (1986): 303-11. [PMID: 3520940]
344	Mulrow C, Lawrence V, Ackermann R, et al. Garlic: effects on cardiovascular risks and disease, protective effects against cancer, and clinical adverse effects.?Evid Rep Technol Assess (Summ). 2000;(20):1-4. [PMID: 11089496]
345	Jiang X, Williams KM, Liauw WS, et al. "Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects." Br J Clin Pharmacol 59 (2005): 425-32. [PMID: 15801937]
346	Kruth P, Brosi E, Fux R, Morike K, Gleiter CH "Ginger-associated overanticoagulation by phenprocoumon." Ann Pharmacother 38 (2004): 257-60. [PMID: 14742762]
347	Benjamin J, Muir T, Briggs K, Pentland B "A case of cerebral haemorrhage - can Ginkgo biloba be implicated?." Postgrad Med J 77 (2001): 112-3. [PMID: 11161079]
348	Chung KF, McCusker M, Page CP, Dent G, Guinot P, Barnes PJ "Effect of ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet acitivating factor in man." Lancet 1 (1987): 248-51. [PMID: 2880069]
349	Cupp MJ "Herbal remedies: adverse effects and drug interactions." Am Fam Physician 59 (1999): 1239-45. [PMID: 10088878]
350	Engelsen J, Nielsen JD, Winther K "Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial." Thromb Haemost 87 (2002): 1075-6. [PMID: 12083489]
351	Fessenden JM, Wittenborn W, Clarke L "Gingko biloba: A case report of herbal medicine and bleeding postoperatively from a laparoscopic cholecystectomy." Am Surg 67 (2001): 33-5. [PMID: 11206893]
352	Fong KC, Kinnear PE "Retrobulbar haemorrhage associated with chronic Gingko biloba ingestion." Postgrad Med J 79 (2003): 531-2. [PMID: 13679551]
353	Jayasekera N, Moghal A, Kashif F, Karalliedde L "Herbal medicines and postoperative haemorrhage." Anaesthesia 60 (2005): 725-6. [PMID: 15960738]
354	Matthews MK Jr "Association of Ginko biloba with intracerebral hemorrhage." Neurology 50 (1998): 1933-4. [PMID: 9633781]
355	Rosenblatt M, Mindel J "Spontaneous hyphema associated with ingestion of Ginkgo biloba extract." N Engl J Med 336 (1997): 1108. [PMID: 9091822]
356	Rowin J, Lewis SL "Spontaneous bilateral subdural hematomas associated with chronic Gingko biloba ingestion." Neurology 46 (1996): 1775-6. [PMID: 8649594]
357	Sierpina VS, Wollschlaeger B, Blumenthal M "Ginkgo biloba." Am Fam Physician 68 (2003): 923-6. [PMID: 13678141]
358	Wolf HR "Does Ginkgo biloba special extract EGb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily?" Drugs R D 7 (2006): 163-72. [PMID: 16752942]
359	Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
360	Janetzky K, Morreale AP "Probable interaction between warfarin and ginseng." Am J Health Syst Pharm 54 (1997): 692-3. [PMID: 9075501]
361	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
362	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
363	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
364	Brass C, Galgiani JN, Blaschke TF, et al "Disposition of ketoconazole, an oral antifungal, in humans." Antimicrob Agents Chemother 21 (1982): 151-8. [PMID: 6282204]
365	Daneshmend TK, Warnock DW "Clinical pharmacokinetics of ketoconazole." Clin Pharmacokinet 14 (1988): 13-34. [PMID: 3280211]
366	Smith AG "Potentiation of oral anticoagulants by ketoconazole." Br Med J 288 (1984): 188-9. [PMID: 6318877]
367	Yeh J, Soo S, Summerton C, Richardson C "Potentiation of action of warfarin by itraconazole." Br Med J 301 (1990): 669. [PMID: 2171705]
368	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
369	Rice AJ, McIntosh TJ, Fouts JR, et al "Decrease sensitivity to warfarin in patients with myxedema." Am J Med Sci 262 (1971): 211-5. [PMID: 5142577]
370	Vagenakis AG, Cote R, Miller ME, et al "Enhancement of warfarin-induced hypoprothrombinemia by thyrotoxicosis." Johns Hopkins Med J 131 (1972): 69-73. [PMID: 4114451]
371	Joss JD, LeBlond RF "Potentiation of warfarin anticoagulation associated with topical methyl salicylate." Ann Pharmacother 34 (2000): 729-33. [PMID: 10860133]
372	Chan TY "Adverse interactions between warfarin and nonsteroidal antiinflammatory drugs: mechanisms, clinical significance, and avoidance." Ann Pharmacother 29 (1995): 1274-83. [PMID: 8672833]
373	Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
374	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
375	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
376	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
377	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
378	Product Information. Ocaliva (obeticholic acid). Intercept Pharmaceuticals, Inc., New York, NY.
379	Li XL, Steiner M "Fish oil: a potent inhibitor of platelet adhesiveness." Blood 76 (1990): 938-45. [PMID: 2118400]
380	Product Information. Vascepa (icosapent). Amarin Pharmaceuticals Inc, Warren, NJ.
381	Product Information. Malarone (atovaquone-proguanil) Glaxo Wellcome, Research Triangle Pk, NC.
382	Warfarin potentiated by proguanil. BMJ 303 (1991): 789. [PMID: 1932962]
383	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
384	Kates RE, Yee YG, Kirsten EB "Interaction between warfarin and propafenone in healthy volunteer subjects." Clin Pharmacol Ther 42 (1987): 305-11. [PMID: 3621785]
385	Product Information. Rhythmol (propafenone). Knoll Pharmaceutical Company, Whippany, NJ.
386	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
387	Product Information. Zolinza (vorinostat). Merck &amp Company Inc, West Point, PA.
388	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
389	Booth SL, Golly I, Sacheck JM, Roubenoff R, Dallal GE, et al "Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status." Am J Clin Nutr 80 (2004): 143-8. [PMID: 15213041]
390	Murohara T, Ikeda H, Otsuka Y, Aoki M, Takajo Y, et al "Inhibition of platelet adherence to Mononuclear cells by alpha-tocopherol: role of P-selection." Circulation 110 (2004): 141-8. [PMID: 15197142]
391	Vitamin K, vitamin E and the coumarin drugs. Nutr Rev 40 (1982): 180-2. [PMID: 7121898]
392	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
393	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
394	De Smet PA, Touw DJ "Safety of St John's wort (Hypericum perforatum)." Lancet 355 (2000): 575-6. [PMID: 10683028]
395	Mauer A, Johne A, Bauer S, et al "Interaction of St. John's wort extract with phenprocoumon." Eur J Clin Pharmacol 55 (1999): A22. [PMID: 10546917]
396	Yue QY, Berquist C, Gerden B "Safety of St John's wort (Hypericum perforatum)." Lancet 355 (2000): 576-7. [PMID: 10683030]
397	Product Information. Bridion (sugammadex). Merck &amp Company Inc, Whitehouse Station, NJ.
398	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
399	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
400	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
401	Zhang Z, Fasco MJ, Huang Z, Guengerich FP, Kaminsky LS "Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe." Drug Metab Dispos 23 (1995): 1339-46. [PMID: 8689941]
402	Havrda DE, Rathbun S, Scheid D "A case report of warfarin resistance due to azathioprine and review of the literature." Pharmacotherpy 21 (2001): 355-7. [PMID: 11253860]
403	Rivier G, Khamashta MA, Hughes GR "Warfarin and azathioprine: a drug interaction does exist." Am J Med 95 (1993): 342. [PMID: 8368235]
404	Rotenberg M, Levy Y, Shoenfeld Y, Almog S, Ezra D "Effect of azathioprine on the anticoagulant activity of warfarin." Ann Pharmacother 34 (2000): 120-2. [PMID: 10669196]
405	Singleton JD, Conyers L "Warfarin and azathioprine: an important drug interaction." Am J Med 92 (1992): 217. [PMID: 1543209]
406	Spiers AS, Mibashan RS "Increased warfarin requirement during mercaptopurine therapy: a new drug interaction." Lancet 2 (1974): 221-2. [PMID: 4135641]
407	Walker J, Mendelson H, McClure A, Smith MD "Warfarin and azathioprine: clinically significant drug interaction." J Rheumatol 29 (2002): 398-9. [PMID: 11838865]
408	Amsden GW "Macrolides versus azalides: a drug interaction update." Ann Pharmacother 29 (1995): 906-17. [PMID: 8547740]
409	Beckey NP, Parra D, Colon A "Retrospective evaluation of a potential interaction between azithromycin and warfarin in patients stabilized on warfarin." Pharmacotherapy 20 (2000): 1055-9. [PMID: 10999497]
410	Foster DR, Milan NL "Potential interaction between azithromycin and warfarin." Pharmacotherapy 19 (1999): 902-8. [PMID: 10417043]
411	Hopkins S "Clinical toleration and safety of azithromycin." Am J Med 91 (1991): s41-5. [PMID: 1656742]
412	Lane G "Increased hypoprothrombinemic effect of warfarin possibly induced by azithromycin." Ann Pharmacother 30 (1996): 884-5. [PMID: 8826581]
413	McCall KL, Anderson HG Jr, Jones AD "Determination of the lack of a drug interaction between azithromycin and warfarin." Pharmacotherapy 24 (2004): 188-94. [PMID: 14998219]
414	Nahata M "Drug interactions with azithromycin and the macrolides: an overview." J Antimicrob Chemother 37 ( Suppl (1996): 133-42. [PMID: 8818854]
415	Product Information. Zithromax (azithromycin). Pfizer US Pharmaceuticals, New York, NY.
416	Rao KB, Pallaki M, Tolbert SR, Hornick TR "Enhanced hypoprothrombinemia with warfarin due to azithromycin." Ann Pharmacother 38 (2004): 982-5. [PMID: 15084685]
417	Shrader SP, Fermo JD, Dzikowski AL "Azithromycin and warfarin interaction." Pharmacotherapy 24 (2004): 945-9. [PMID: 15303459]
418	Williams D, Ponte CD "Warfarin-associated hypoprothrombinemia: an unusual presentation." Am J Health Syst Pharm 60 (2003): 274-8. [PMID: 12613238]
419	Woldtvedt BR, Cahoon CL, Bradley LA, Miller SJ "Possible increased anticoagulation effect of warfarin induced by azithromycin" Ann Pharmacother 32 (1998): 269-70. [PMID: 9496419]
420	Murphey LM, Hood EH "Bosentan and warfarin interaction." Ann Pharmacother 37 (2003): 1028-31. [PMID: 12841813]
421	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
422	Denbow CE, Frazer HS "Clinically significant hemorrhage due to warfarin-carbamazepine interaction." South Med J 83 (1990): 981. [PMID: 2382161]
423	Kendall AG, Boivin M "Warfarin-carbamazepine interaction." Ann Intern Med 94 (1981): 280. [PMID: 7469228]
424	Massey EW "Effect of carbamazepine on coumadin metabolism." Ann Neurol 13 (1983): 691-2. [PMID: 6881938]
425	Ross JR, Beeley L "Interaction between carbamazepine and warfarin." Br Med J 280 (1980): 1415-6. [PMID: 7427137]
426	Le AT, Hasson NK, Lum BL "Enhancement of warfarin response in a patient receiving etoposide and carboplatin chemotherapy." Ann Pharmacother 31 (1997): 1006-8. [PMID: 9296241]
427	Seifter EJ, Brooks BJ, Urba WJ "Possible interactions between warfarin and antineoplastic drugs." Cancer Treat Rep 69 (1985): 244-5. [PMID: 3971397]
428	Haase KK, Roias-Fernandez CH "Potential interaction between celecoxib and warfarin." Ann Pharmacother 34 (2000): 666-7. [PMID: 10852097]
429	Karim A, Tolbert D, Piergies A, et al. "Celecoxib does not significantly alter the pharmacokinetics or hypoprothrombinemic effect of warfarin in healthy subjects." J Clin Pharmacol 40 (2000): 655-63. [PMID: 10868317]
430	Leese PT, Hubbard RC, Karim A, Isakson PC, Yu SS, Geis GS "Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: A randomized, controlled trial." J Clin Pharmacol 40 (2000): 124-32. [PMID: 10664917]
431	Linder JD, Klaus E, Monkemuller KE, Davis JV, Wilcox CM "Cyclooxygenase-2 inhibitor celecoxib: a possible cause of gastropathy and hypoprothrombinemia." South Med J 93 (2000): 930-2. [PMID: 11005360]
432	Malhi H, Atac B, Daly AK, Gupta S "Warfarin and celecoxib interaction in the setting of cytochrome P450 (CYP2C9) polymorphism with bleeding complication." Postgrad Med J 80 (2004): 107-109. [PMID: 14970301]
433	Mersfelder TL, Stewart LR "Warfarin and celecoxib interaction." Ann Pharmacother 34 (2000): 325-7. [PMID: 10917378]
434	Product Information. Celebrex (celecoxib). Searle, Chicago, IL.
435	Stading JA, Skrabal MZ, Faulkner MA "Seven cases of interaction between warfarin and cyclooxygenase-2 inhibitors." Am J Health Syst Pharm 58 (2001): 2076-80. [PMID: 11715832]
436	Stoner SC, Lea JW, Dubisar BM, Farrar C "Possible international normalized ratio elevation associated with celecoxib and warfarin in an elderly psychiatric patient." J Am Geriatr Soc 51 (2003): 728-729. [PMID: 12752860]
437	Ambrose PJ "Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate." Clin Pharmacokinet 9 (1984): 222-38. [PMID: 6375931]
438	Christensen LK, Skovsted L "Inhibition of drug metabolism by chloramphenicol." Lancet 2 (1969): 1397-9. [PMID: 4188280]
439	Matsaniotis J, Messaritakis J, Vlachou C "Hypoprothrombinaemic bleeding in infants associated with diarrhoea and antibiotics." Arch Dis Child 45 (1970): 586-7. [PMID: 5506950]
440	Udall JA "Human sources and absorption of vitamin K in relation to anticoagulation stability." JAMA 194 (1965): 107-9. [PMID: 5897315]
441	Yacobi A, et al "Pharmacokinetics and pharmacodynamic studies of acute interaction between warfarin enantiomers and chloramphenicol in rats." J Pharmacol Exp Ther 231 (1984): 80-4. [PMID: 6491977]
442	Hansen JM, Christensen LK "Drug interactions with oral sulphonylurea hypoglycaemic drugs." Drugs 13 (1977): 24-34. [PMID: 401727]
443	Jahnchen E, Meinertz T, Gilfrich HJ, Groth U "Pharmacokinetic analysis of the interaction between dicoumarola and tolbutamide in man." Eur J Clin Pharmacol 10 (1976): 349-56. [PMID: 61862]
444	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
445	Breckenridge AM, Challiner M, Mossman S, et al "Cimetidine increases the action of warfarin in man." Br J Clin Pharmacol 8 (1979): p392-3. [PMID: 508530]
446	Choonara IA, Cholerton S, Haynes BP, Breckenridge AM, Park BK "Stereoselective interaction between the R enantiomer of warfarin and cimetidine." Br J Clin Pharmacol 21 (1986): 271-7. [PMID: 2938614]
447	Desmond PV, Mashford ML, Harman PJ, Morphett BJ, Breen KJ, Wang YM "Decreased oral warfarin clearance after ranitidine and cimetidine." Clin Pharmacol Ther 35 (1984): 338-41. [PMID: 6321081]
448	Flind AC "Cimetidine and oral anticoagulants ." Br Med J 2 (1978): 1367. [PMID: 719395]
449	Flind AC "Cimetidine and oral anticoagulants ." Lancet 2 (1978): 1054. [PMID: 82071]
450	Kerley B, Ali M "Cimetidine potentiation of warfarin action." Can Med Assoc J 126 (1982): 116. [PMID: 7059881]
451	Niopas I, Toon S, Rowland M "Further insight into the stereoselective interaction between warfarin and cimetidine in man." Br J Clin Pharmacol 32 (1991): 508-11. [PMID: 1958448]
452	O'Reilly RA "Comparative interaction of cimetidine and ranitidine with racemic warfarin in man." Arch Intern Med 144 (1984): 989-91. [PMID: 6324710]
453	Serlin MJ, Challiner M, Park BK, Turcan PA, Breckenridge AM "Cimetidine potentiates the anticoagulant effect of warfarin by inhibition of drug metabolism." Biochem Pharmacol 29 (1980): 1971-2. [PMID: 7397004]
454	Serlin MJ, Sibeon RG, Mossman S, et al "Cimetidine: interaction with oral anticoagulants in man." Lancet 2 (1979): 317-9. [PMID: 89387]
455	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
456	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
457	Product Information. Xiaflex (collagenase clostridium histolyticum). Auxilium Pharmaceuticals Inc, Norristown, PA.
458	Arbex MA, Varella Mde C, Siqueira HR, Mello FA "Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs." J Bras Pneumol 36 (2010): 641-56
459	Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
460	Jones RV "Warfarin and distalgesic interaction." Br Med J 1 (1976): 460
461	Orme M, Breckenridge A, Cook P "Warfarin and distalgesic interaction." Br Med J 1 (1976): 200
462	Donaldson DR, Sreeharan N, Crow MJ, Rajah SM "Assessment of the interaction of warfarin with aspirin and dipyridamole." Thromb Haemost 47 (1982): 77. [PMID: 6978549]
463	Haworth E, Burroughs AK "Disopyramide and warfarin interaction." Br Med J 2 (1977): 866-7. [PMID: 922330]
464	Massel D, Little SH "Risks and benefits of adding anti-platelet therapy to warfarin among patients with prosthetic heart valves: A meta-analysis." J Am Coll Cardiol 37 (2001): 569-78. [PMID: 11216981]
465	Product Information. Persantine (dipyridamole). Boehringer-Ingelheim, Ridgefield, CT.
466	Rhodes RS, Rhodes PJ, Klein C, Sintek CD. A warfarin-piroxicam drug interaction.?Drug Intell Clin Pharm. 1985;19(7-8):556-558. [PMID: 4028961]
467	Sylven C, Anderson P "Evidence that disopyramide does not interact with warfarin." Br Med J 286 (1983): 1181. [PMID: 6404381]
468	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
469	Thomas KS, Billingsley A, Amarshi N, Nair BA "Elevated International Normalized Ratio associated with concomitant warfarin and erlotinib." Am J Health Syst Pharm 67 (2010): 1426-9. [PMID: 20720241]
470	Breckenridge A "Clinical implications of enzyme induction." Basic Life Sci 6 (1975): 273-301. [PMID: 239673]
471	Havrda DE, Mai T, Chonlahan J "Enhanced antithrombotic effect of warfarin associated with low-dose alcohol consumption." Pharmacotherapy 25 (2005): 303-7. [PMID: 15767245]
472	Karlson B, Leijd B, Hellstrom K "On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment." Acta Med Scand 220 (1986): 347-50. [PMID: 3541503]
473	Udall JA "Drug interference with warfarin therapy." Clin Med 77 (1970): 20-5. [PMID: 1109248]
474	Glue P, Banfield CR, Colucci RD, Perhach JL "Warfarin-felbamate interaction." Ann Pharmacother 28 (1994): 1412-3. [PMID: 7696739]
475	Tisdel KA, Israel DS, Kolb KW "Warfarin-felbamate interaction: first report." Ann Pharmacother 28 (1994): 805. [PMID: 7919574]
476	Product Information. Eulexin (flutamide). Schering Laboratories, Kenilworth, NJ.
477	Limke KK, Shelton AR, Elliott ES "Fluvoxamine interaction with warfarin." Ann Pharmacother 36 (2002): 1890-2. [PMID: 12452751]
478	Hsu PL, Ma JK, Luzzi LA "Interactions of sulfonylureas with plasma proteins." J Pharm Sci 63 (1974): 570-3. [PMID: 4208196]
479	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
480	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
481	Okino K, Weibert RT "Warfarin-griseofulvin interaction." Drug Intell Clin Pharm 20 (1986): 291-3. [PMID: 3698827]
482	Product Information. Sintrom (nicoumalone). Novartis Pharmaceuticals Canada Inc, Dorval, QC.
483	Eade NR, McLeod PJ, MacLeod SM "Potentiation of bishydroxycoumarin in dogs by isoniazid and paminosalicylic acid." Am Rev Respir Dis 103 (1971): 792-9. [PMID: 4103778]
484	Rosenthal AR, Self TH, Baker ED, Lincen RA "Interaction of isoniazid and warfarin." JAMA 238 (1977): 2177. [PMID: 578833]
485	Fiallo P "Reduced therapeutic activity of warfarin during treatment with oral isotretinoin." Br J Dermatol 150 (2004): 164
486	Chonlahan J, Halloran MA, Hammonds A "Leflunomide and warfarin interaction: case report and review of the literature." Pharmacotherapy 26 (2006): 868-71. [PMID: 16716139]
487	Lim V, Pande I "Leflunomide can potentiate the anticoagulant effect of warfarin." BMJ 325 (2002): 1333. [PMID: 12468482]
488	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
489	Costigan DC, Freedman MH, Ehrlich RM "Potentiation of oral anticoagulant effect by l-thyroxine." Clin Pediatr (Phila) 23 (1984): 172-4. [PMID: 6697623]
490	van Oosterom AT, Mattie H, Hermens WT, Veltkamp JJ "The influence of the thyroid function on the metabolic rate of prothrombin, factor VII, and factor X in the rat." Thromb Haemost 35 (1976): 607-19. [PMID: 989968]
491	Walters MB "The relationship between thyroid function and anticoagulant therapy." Am J Cardiol 11 (1963): 112-4. [PMID: 13998701]
492	Product Information. Zyvox (linezolid) Pharmacia and Upjohn, Kalamazoo, MI.
493	Sakai Y, Naito T, Arima C, et al. "Potential drug interaction between warfarin and linezolid." Intern Med 54 (2015): 459-64
494	Kinoshita S, Wada K, Kuwahara T, et.al "Interaction between warfarin and linezolid in patients with left ventricular assist system in Japan." Intern Med 55 (2016): 719-24
495	Cuddy PG, Loftus LS "Influence of mitotane on the hypoprothrombinemic effect of warfarin." South Med J 79 (1986): 387-8. [PMID: 3952554]
496	Product Information. Lysodren (mitotane). Bristol-Myers Squibb, Princeton, NJ.
497	MacWalter RS, Fraser HW, Armstrong KM "Orlistat enhances warfarin effect." Ann Pharmacother 37 (2003): 510-2. [PMID: 12659605]
498	Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.
499	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
500	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
501	Howard PA, Hannaman KN "Warfarin resistance linked to enteral nutrition products." J Am Diet Assoc 85 (1985): 713-5. [PMID: 3998343]
502	Kempin SJ "Warfarin resistance caused by broccoli." N Engl J Med 308 (1983): 1229-30. [PMID: 6843604]
503	Lee M, Schwartz RN, Sharifi R "Warfarin resistance and vitamin K." Ann Intern Med 94 (1981): 140-1. [PMID: 7447217]
504	Koch-Weser J "Quinidine-induced hypoprothrombinemic hemorrhage in patients on chronic warfarin therapy." Ann Intern Med 68 (1968): 511-7
505	Product Information. Copegus (ribavirin). Roche Laboratories, Nutley, NJ.
506	Product Information. Rebetol (ribavirin). Schering-Plough Corporation, Kenilworth, NJ.
507	Schulman S "Inhibition of warfarin activity by ribavirin." Ann Pharmacother 36 (2002): 72-4
508	Product Information. Crestor (rosuvastatin). AstraZeneca Pharma Inc, Mississauga, ON.
509	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
510	Laber DA, Mushtaq M "Compassionate use of sorafenib in patients with advanced renal cell cancer." Clin Genitourin Cancer 7 (2009): 34-8. [PMID: 19213666]
511	Moretti LV, Montalvo RO "Elevated International Normalized Ratio associated with concurrent use of sorafenib and warfarin." Am J Health Syst Pharm 66 (2009): 2123-2125. [PMID: 19923313]
512	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
513	Kolilekas L, Anagnostopoulos GK, Lampaditis I, Eleftheriadis I "Potential Interaction Between Telithromycin and Warfarin (September)." Ann Pharmacother 38 (2004): 1424-7. [PMID: 15280511]
514	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
515	Gidal BE, Sorkness CA, McGill KA, Larson R, Levine RR "Evaluation of a potential enantioselective interaction between ticlopidine and warfarin in chronically anticoagulated patients." Ther Drug Monit 17 (1995): 33-8. [PMID: 7725374]
516	Product Information. Ticlid (ticlopidine). Syntex Laboratories Inc, Palo Alto, CA.
517	Product Information. Tindamax (tinidazole). Presutti Laboratories Inc, Arlington Heights, IL.
518	Lodwick R, McConkey B, Brown AM, Beeley L "Life threatening interaction between tamoxifen and warfarin." Br Med J 295 (1987): 1141. [PMID: 3120919]
519	Tenni P, Lalich DL, Byrne MJ "Life threatening interaction between tamoxifen and warfarin." BMJ 298 (1989): 93. [PMID: 2493305]
520	Guthrie SK, Stoysich AM, Bader G, Hilleman DE "Hypothesized interaction between valproic acid and warfarin." J Clin Psychopharmacol 15 (1995): 138-9. [PMID: 7782487]
521	Product Information. Depakene (valproic acid). Abbott Pharmaceutical, Abbott Park, IL.
522	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
523	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
524	Celestini A, Pulcinelli FM, Pignatelli P, et al. "Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets." Haematologica 87 (2002): 420-6. [PMID: 11940487]
525	Corrigan JJ "The effect of vitamin E on warfarin-induced vitamin K deficiency." Ann N Y Acad Sci 393 (1982): 361-8. [PMID: 6959563]
526	Corrigan JJ, Ulfers LL "Effect of vitamin E on prothrombin levels in warfarin-induced vitamin K deficiency." Am J Clin Nutr 34 (1981): 1701-5. [PMID: 7282596]
527	Freedman JE, Farhat JH, Loscalzo J, Keaney JF "Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C--dependent mechanism." Circulation 94 (1996): 2434-40. [PMID: 8921785]
528	Gonzalez-Correa JA, Arrebola MM, Guerrero A, et al. "Influence of vitamin E on the antiplatelet effect of acetylsalicylic acid in human blood." Platelets 16(3-4) (2005): 171-9. [PMID: 16011961]
529	Helson L "The effect of intravenous vitamin E and menadiol sodium diphosphate on vitamin K dependent clotting factors." Thromb Res 35 (1984): 11-8. [PMID: 6474408]
530	Jandak J, Steiner M, Richardson PD "Alpha-tocopherol, an effective inhibitor of platelet adhesion." Blood 73 (1989): 141-9. [PMID: 2910355]
531	Kakishita E, Suehiro A, Oura Y, Nagai K "Inhibitory effect of vitamin E (alpha-tocopherol) on spontaneous platelet aggregation in whole blood." Thromb Res 60 (1990): 489-99. [PMID: 2082481]
532	Kim JM, White RH "Effect of vitamin E on the anticoagulant response to warfarin." Am J Cardiol 77 (1996): 545-6. [PMID: 8629604]
533	Liu M, Wallmon A, Olsson-Mortlock C, Wallin R, Saldeen T "Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms." Am J Clin Nutr 77 (2003): 700-6. [PMID: 12600864]
534	Mardla V, Kobzar G, Samel N "Potentiation of antiaggregating effect of prostaglandins by alpha-tocopherol and quercetin." Platelets 15 (2004): 319-24. [PMID: 15370103]
535	Megavitamin E supplementation and vitamin K-dependent carboxylation. Nutr Rev 41 (1983): 268-70. [PMID: 6358960]
536	Schrogie JJ "Coagulopathy and fat-soluble vitamins." JAMA 232 (1975): 19. [PMID: 1172961]
537	Stampfer MJ, Jakubowski JA, Faigel D, Vaillancourt R, Deykin D "Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels." Am J Clin Nutr 47 (1988): 700-6. [PMID: 3128100]
538	Shalansky S, Lynd L, Richardson K, Ingaszewski A, Kerr C "Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis." Pharmacotherapy 27 (2007): 1237-47. [PMID: 17723077]
539	Dekhuijzen PN, Koopmans PP "Pharmacokinetic profile of zafirlukast." Clin Pharmacokinet 41 (2002): 105-14. [PMID: 11888331]
540	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
541	Product Information. Casodex (bicalutamide). Zeneca Pharmaceuticals, Wilmington, DE.
542	Lambert JP, Cormier J "Potential interaction between warfarin and boldo-fenugreek." Pharmacotherapy 21 (2001): 509-12. [PMID: 11310527]
543	Saeed SA, Gilani AH "Antithrombotic activity of clove oil." J Pak Med Assoc 44 (1994): 112-5. [PMID: 8078176]
544	Srivasta KC "Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]" Prostaglandins Leukot Essent Fatty Acids 48 (1993): 363-72. [PMID: 8321872]
545	Srivstava KC, Malhotra N "Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets." Prostaglandins Leukot Essent Fatty Acids 42 (1991): 73-81. [PMID: 2011614]
546	Product Information. Adlyxin (lixisenatide). sanofi-aventis, Bridgewater, NJ.
547	Product Information. Dipentum (olsalazine). Meda Pharmaceuticals, Somerset, NJ.
548	Robinson DS, Sylwester D "Interaction of commonly prescribed drugs and warfarin." Ann Intern Med 72 (1970): 853-6. [PMID: 5448744]
549	Abebe W "Herbal medication: potential for adverse interactions with analgesic drugs." J Clin Pharm Ther 27 (2002): 391-401. [PMID: 12472978]
550	Yang X, Thomas DP, Zhang X, et al "Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation." Arterioscler Thromb Vasc Biol 26 (2006): 85-90. [PMID: 16239599]
551	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
552	Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS "Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia." Drugs 19 (1980): 161-80. [PMID: 6988203]
553	Product Information. Colestid (colestipol HCI). Pharmacia and Upjohn, Kalamazoo, MI.
554	Jungnickel PW, Cantral KA, Maloley PA "Pravastatin: a new drug for the treatment of hypercholesterolemia." Clin Pharm 11 (1992): 677-89. [PMID: 1511541]
555	Pan HY "Clinical pharmacology of pravastatin, a selective inhibitor of HMg-CoA reductase." Eur J Clin Pharmacol 40 Suppl 1 (1991): s15-8. [PMID: 1904355]
556	Product Information. Pravachol (pravastatin). Bristol-Myers Squibb, Princeton, NJ.
557	Gaw A, Wosornu D "Simvastatin during warfarin therapy in hyperlipoproteinaemia." Lancet 340 (1992): 979-80. [PMID: 1357387]
558	Lin JC, Ito MK, Stolley SN, Morreale AP, Marcus DB "The effect of converting from pravastatin to simvastatin on the pharmacodynamics of warfarin." J Clin Pharmacol 39 (1999): 86-90. [PMID: 9987704]
559	Mauro VF "Clinical pharmacokinetics and practical applications of simvastatin." Clin Pharmacokinet 24 (1993): 195-202. [PMID: 8343198]
560	Mogyorosi A, Bradley B, Showalter A, Schubert ML "Rhabdomyolysis and acute renal failure due to combination therapy with simvastatin and warfarin." J Intern Med 246 (1999): 599-602. [PMID: 10620105]
561	Product Information. Zocor (simvastatin). Merck & Co, Inc, West Point, PA.
562	Walker JF "Simvastatin: the clinical profile." Am J Med 87 (1989): s44-6. [PMID: 2801750]
563	O'Reilly RA "Spironolactone and warfarin interaction." Clin Pharmacol Ther 27 (1980): 198-201
564	Product Information. Tasmar (tolcapone). Valeant Pharmaceuticals, Costa Mesa, CA.
565	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
566	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
567	Hardy JL, Sirois A "Reduction of prothrombin and partial thromboplastin times with trazodone." Can Med Assoc J 135 (1986): 1372

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