Drug General Information (ID: DDI6DV0C4I)
Drug Name			Chlorothiazide		Drug Info		Anisindione		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Anticoagulants
Structure

Mechanism of Chlorothiazide-Anisindione Interaction (Severity Level: Minor)
Antagonize the effect of antithrombotic agents Click to Show/Hide Mechanism Graph
Drug Name		Chlorothiazide				Anisindione
Mechanism		Increase in plasma levels of clotting factors due to reduction in intravascular volume				Anticoagulant
Key Mechanism Factor 1
		Factor Name		Antithrombotic agents
		Factor Description		The beneficial effects of antithrombotic agents are reduced, leading to an increased risk of thromboembolism, stroke and/or myocardial infarction.
Mechanism Description		Antagonize the effect of Anisindione when combined with Chlorothiazide

References
1	Koch-Weser J, Sellers EM "Drug interactions with coumarin anticoagulants (first of two parts)." N Engl J Med 285 (1971): 487-98. [PMID: 4397794]
2	Ku LL, Ward CO, Durgin SJ "A clinical study of drug interaction and anticoagulant therapy." Drug Intell Clin Pharm 4 (1970): 300-6.
3	Robinson DS, Sylwester D "Interaction of commonly prescribed drugs and warfarin." Ann Intern Med 72 (1970): 853-6. [PMID: 5448744]