Details of Drug-Drug Interaction
| Drug General Information (ID: DDIF6VGE74) | |||||||||
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| Drug Name | Acetylsalicylic acid | Drug Info | Anisindione | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Analgesics | Anticoagulants | |||||||
| Structure | |||||||||
| Mechanism of Acetylsalicylic acid-Anisindione Interaction (Severity Level: Major) | |||||||||
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| Increased risk of bleeding Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Acetylsalicylic acid | Anisindione | |||||||
| Mechanism |
Risk of bleeding Antiplatelet |
Risk of bleeding Anticoagulant |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Bleeding | ||||||||
| Factor Description | Patients may be at risk for bleeding when the outcome of a disease or disease treatment confounds the standard mechanisms for maintaining hemostasis. Signs or symptoms of abnormal bleeding include: bleeding that takes a long time to stop (including nosebleeds, bleeding gums, bleeding from cuts and abrasions, and menstrual bleeding); severe unexplained bruising, or bruising that becomes larger; blood in the urine or stool, etc. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | This combination, especially with analgesic/antipyretic aspirin doses, should generally be avoided unless the potential benefit outweighs the risk of bleeding. If concomitant therapy is used for additive anticoagulant effects, monitoring for excessive anticoagulation and overt and occult bleeding is recommended. The INR should be checked frequently and the dosage adjusted accordingly when aspirin is added to an anticoagulant regimen. Be cognizant that bleeding may occur without INR or prothrombin time increases. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bruising, red or brown urine, or red or black stools. Patients should also be counseled to avoid any other over-the-counter oral or topical salicylate products. | ||||||||