Details of Drug-Drug Interaction
| Drug General Information (ID: DDIN40KV6Q) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Ticlopidine | Drug Info | Anisindione | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Fibrinolytic Agents | Anticoagulants | |||||||
| Structure | |||||||||
| Mechanism of Ticlopidine-Anisindione Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of bleeding Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Ticlopidine | Anisindione | |||||||
| Mechanism |
Risk of bleeding Antiplatelet |
Risk of bleeding Anticoagulant |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Bleeding | ||||||||
| Factor Description | Patients may be at risk for bleeding when the outcome of a disease or disease treatment confounds the standard mechanisms for maintaining hemostasis. Signs or symptoms of abnormal bleeding include: bleeding that takes a long time to stop (including nosebleeds, bleeding gums, bleeding from cuts and abrasions, and menstrual bleeding); severe unexplained bruising, or bruising that becomes larger; blood in the urine or stool, etc. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | The manufacturer recommends discontinuation of any anticoagulants before initiating ticlopidine therapy. If concomitant use cannot be avoided, patients should be closely monitored for signs of bleeding and the anticoagulant dosage should be adjusted as appropriate to maintain therapeutic aPTT/INR values. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bruising, red or brown urine, or red or black stools. | ||||||||