Drug General Information (ID: DDIUHXMJZB)
  Drug Name Colestipol Drug Info Anisindione Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Bile Acid Sequestrants Anticoagulants
  Structure

 Mechanism of Colestipol-Anisindione Interaction (Severity Level: Minor)
     Complex formation Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Colestipol Anisindione
      Mechanism Anion exchange resin/polymer Binds to anion exchange resin/polymer
      Key Mechanism Factor 1
Factor Name Chelation
Factor Description Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
      Mechanism Description
  • Decreased absorption of Colestipol due to formation of complexes caused by Anisindione 

References
1 Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS "Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia." Drugs 19 (1980): 161-80. [PMID: 6988203]
2 Product Information. Colestid (colestipol HCI). Pharmacia and Upjohn, Kalamazoo, MI.