Details of Drug

Drug General Information (ID: D0382)
Drug Name	Colestipol
Drug Type	Small molecule
Drug Synonymous	Colestid; Colestipol Hydrochloride; Flavored Colestid Click to Show/Hide
Disease Class	5C80: Hyper-lipoproteinaemia
Therapeutic Class	Bile Acid Sequestrants
Structure
Structure	3D Structure		2D Structure
Formula	C11H28ClN5O
InChI	1S/C8H23N5.C3H5ClO/c9-1-3-11-5-7-13-8-6-12-4-2-10;4-1-3-2-5-3/h11-13H,1-10H2;3H,1-2H2
InChIKey	GMRWGQCZJGVHKL-UHFFFAOYSA-N
Canonical SMILES	C1C(O1)CCl.C(CNCCNCCNCCN)N
External Link
	Pubchem ID	62816
	CAS Number	90366-83-9
	TTD ID	D0GJ8R
	VARIDT ID	DR01034

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption BM003 Complex formation BM008 Altered Fat-soluble drugs absorption
Relation Graph

Full list of drugs interacting with Colestipol
Affected gastrointestinal absorption
	Complex formation					Drug Num: 64
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[1]
D1095		Mycophenolic acid	C17H20O6	446541	Major		Inter Info	[1]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[2]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[8], [9], [10]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[8], [9], [10]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[8], [9], [10]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[11], [12], [10], [13], [7]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[14], [10]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[15]
D0310		Chenodeoxycholic acid	C24H40O4	10133	Moderate		Inter Info	[16], [13], [7]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[8], [9], [10]
D0330		Cholic Acid	C24H40O5	221493	Moderate		Inter Info	[17]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[18]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[11], [12], [10], [13], [7]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[11], [12], [10], [13], [7]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[19], [20], [14], [10], [21]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[19], [20], [14], [10], [21]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[24], [13], [26]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[14], [10]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[24], [13], [26]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[27], [28], [29]
D0643		Fenofibric acid	C17H15ClO4	64929	Moderate		Inter Info	[27], [28], [29]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[11], [12], [10], [13], [7]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[15]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[14], [10]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[11], [12], [10], [13], [7]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[8], [9], [10]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[8], [9], [10]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[36]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[24], [13], [26]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[11], [12], [10], [13], [7]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[8], [9], [10]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[24], [13], [26]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[37]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[8], [9], [10]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[11], [12], [10], [13], [7]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[11], [12], [10], [13], [7]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D1376		Raloxifene	C28H27NO4S	5035	Moderate		Inter Info	[38]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[15]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[11], [12], [10], [13], [7]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[8], [9], [10]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[2]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[22], [23], [3], [24], [25], [13], [26]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[24], [13], [26]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[15]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[14], [10]
D0087		Anisindione	C16H12O3	2197	Minor		Inter Info	[20], [10]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Minor		Inter Info	[39], [20], [10]
D1070		Minocycline	C23H27N3O7	54675783	Minor		Inter Info	[39], [20], [10]
D1209		Oxytetracycline	C22H24N2O9	54675779	Minor		Inter Info	[39], [20], [10]
D1564		Tetracycline	C22H24N2O8	54675776	Minor		Inter Info	[39], [20], [10]
D1711		Warfarin	C19H16O4	54678486	Minor		Inter Info	[20], [10]
D0481		Dicoumarol	C19H12O6	54676038	Minor		Inter Info	[40], [20], [10]
D0530		Doxycycline	C22H24N2O8	54671203	Minor		Inter Info	[39], [20], [10]
	Altered Fat-soluble drugs absorption					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0233		Calcifediol	C27H44O2	5283731	Moderate		Inter Info	[3], [2], [4], [5], [6], [7]
D0234		Calcitriol	C27H44O3	5280453	Moderate		Inter Info	[3], [2], [4], [5], [6], [7]
D0495		Dihydrotachysterol	C28H46O	5311071	Moderate		Inter Info	[3], [2], [4], [5], [6], [7]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[3], [2], [4], [5], [6], [7]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[27], [3], [2], [30], [31]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[32], [33], [34], [13], [35]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[32], [33], [34], [13], [35]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[3], [2], [4], [5], [6], [7]
D1284		Phylloquinone	C31H46O2	5284607	Moderate		Inter Info	[3], [2], [7]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[32], [33], [34]
D0591		Ergocalciferol	C28H44O	5280793	Moderate		Inter Info	[3], [2], [4], [5], [6], [7]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[32], [33], [34], [13], [35]
D1702		Vitamin A	C20H30O	445354	Moderate		Inter Info	[3], [2], [4], [5], [6], [7]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[3], [2], [4], [5], [6], [7]

References
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2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
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5	Product Information. Fosamax Plus D (alendronate-cholecalciferol). Merck & Company Inc, West Point, PA.
6	Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
7	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
8	Hunninghake DB, King S, LaCroix K "The effect of cholestyramine and colestipol on the absorption of hydrochlorothiazide." Int J Clin Pharmacol Ther Toxicol 20 (1982): 151-4. [PMID: 7076343]
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10	Product Information. Colestid (colestipol HCI). Pharmacia and Upjohn, Kalamazoo, MI.
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