Drug General Information (ID: DDIRNLO8UP)
Drug Name			Colestipol		Drug Info		Tetracycline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bile Acid Sequestrants				Antibiotics
Structure

Mechanism of Colestipol-Tetracycline Interaction (Severity Level: Minor)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Colestipol				Tetracycline
Mechanism		Anion exchange resin/polymer				Binds to anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Colestipol due to formation of complexes caused by Tetracycline

References
1	Friedman H, Greenblatt DJ, LeDuc BW "Impaired absorption of tetracycline by colestipol is not reversed by orange juice." J Clin Pharmacol 29 (1989): 748-51. [PMID: 2778097]
2	Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS "Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia." Drugs 19 (1980): 161-80. [PMID: 6988203]
3	Product Information. Colestid (colestipol HCI). Pharmacia and Upjohn, Kalamazoo, MI.