Details of Drug

Drug General Information (ID: D1564)
Drug Name	Tetracycline
Drug Type	Small molecule
Drug Synonymous	Amycin; Biocycline; Bristaciclin; Bristaciclina; Bristacycline; Ciclibion; Copharlan; Cyclomycin; Cytome; Dumocyclin; Enterocycline; Medocycline; Resteclin; Robitet; Sanclomycine; Tetrachel; Veracin; Bristaciclin alpha; Cefracycline suspension; Component of Tetrastatin; Sumycin syrup; Tetracycline Free Base; Tetracycline I; Tetracycline II; Tetracycline Monohydrochloride; Achromycin (naphthacene derivative); Achromycin, naphthacene derivative; Centet (base); Lemtrex (base); Liquamycin (Veterinary); Liquamycin, veterinary; Panmycin (TN); Piracaps (base); Polycycline (VAN); Polycycline (antibiotic); Polycycline, antibiotic; SK-Tetracycline; Sumycin (TN); T-125; Tetra-Co; Tetraciclina [INN-Spanish]; Tetracycline & VRC3375; Tetracycline (internal use); Tetracyclinum [INN-Latin]; Tetracyn (TN); Vetquamycin-324 (free base); Tetracycline (JAN/USP/INN); Tetracycline [USAN:INN:BAN:JAN]; Methyl-1,11-dioxo-2-naphthacenecarboxamide; 6-Methyl-1,11-dioxy-2-naphthacenecarboxamide Click to Show/Hide
Disease Class	1A00-1C4Z: Bacterial infection
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C22H24N2O8
InChI	1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25-26,29,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
InChIKey	NWXMGUDVXFXRIG-WESIUVDSSA-N
Canonical SMILES	CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
External Link
	Pubchem ID	54675776
	CAS Number	60-54-8
	CHEBI ID	27902
	TTD ID	D08NQZ
	INTEDE ID	DR1568
	VARIDT ID	DR00127

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM002 Altered intestinal flora BM003 Complex formation BM004 Adsorption BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM029 Altered urine pH BM045 Additive neuromuscular blocking effects BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM072 Increased risk of nephrotoxicity BM075 Increased risk of photosensitivity reactions BM077 Increased risk of pseudotumor cerebri BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Tetracycline
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1046		Metoclopramide	C14H22ClN3O2	4168	Minor		Inter Info	[5], [20], [141], [142]
	Altered intestinal flora					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[50], [51], [52], [53]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[62], [63]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[50], [51], [52], [53]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[62], [63]
	Complex formation					Drug Num: 41
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0235		Calcium acetate	C4H6CaO4	6116	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0240		Calcium glucoheptonate	C14H26CaO16	62859	Moderate		Inter Info	[40], [43], [46]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D1511		Sucralfate	C12H54Al9O55S8	121494085	Moderate		Inter Info	[77], [78], [79]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0125		Attapulgite	Al2H29Mg2O15Si4-	56842194	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0185		Bismuth subcitrate potassium	C12H10BiK5O14+2	53297469	Moderate		Inter Info	[108], [109], [44], [10]
D0186		Bismuth subgallate	C7H6BiO6	16682999	Moderate		Inter Info	[108], [109], [44], [10]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0237		Calcium chloride	CaCl2H4O2	24844	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0238		Calcium citrate	C12H10Ca3O14	13136	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0239		Calcium glubionate anhydrous	C18H32CaO19	64776	Moderate		Inter Info	[40], [43], [46]
D0241		Calcium gluconate	C12H22CaO14	9290	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0243		Calcium lactate	C6H10CaO6	13144	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0244		Calcium Phosphate	Ca3O8P2	24456	Moderate		Inter Info	[40], [43], [46]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[110], [111], [112]
D0649		Ferrous fumarate	C4H2FeO4	6433164	Moderate		Inter Info	[113], [114], [115], [116], [42], [117], [118], [119], [44], [10], [120]
D0651		Ferrous sulfate anhydrous	FeO4S	24393	Moderate		Inter Info	[114], [115], [44]
D0847		Iron	Fe	23925	Moderate		Inter Info	[114], [115], [44]
D0849		Iron protein succinylate	NA	NA	Moderate		Inter Info	[113], [114], [115], [116], [42], [117], [118], [119], [44], [10], [120]
D0850		Iron sucrose	C12H29Fe5Na2O23	91663255	Moderate		Inter Info	[42], [44], [123]
D0877		Kaolin	Al2H4O9Si2	56841936	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0893		Lanthanum carbonate	C3La2O9	168924	Moderate		Inter Info	[57], [5], [20], [127], [44], [10]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0969		Magnesium chloride	Cl2H12MgO6	643991	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0971		Magnesium gluconate	C12H22MgO14	11418570	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0972		Magnesium glycinate	C4H8MgN2O4	84645	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[37], [38], [39], [40], [41], [42], [43], [28], [44], [10], [45], [46], [47]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[110], [111], [112]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[20], [44], [10]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[108], [109], [44]
D1566		Tetraferric tricitrate decahydrate	C18H32Fe4O31	90478690	Moderate		Inter Info	[131], [44], [10]
D1722		Zinc acetate	C4H6O4Zn	11192	Moderate		Inter Info	[115], [42], [132], [44], [10]
D1723		Zinc chloride	Cl2Zn	5727	Moderate		Inter Info	[115], [42], [132], [44], [10]
D1724		Zinc gluconate	C12H22O14Zn	443445	Moderate		Inter Info	[115], [42], [132], [44], [10]
D1725		Zinc sulfate	O4SZn	24424	Moderate		Inter Info	[115], [42], [132], [44], [10]
D0382		Colestipol	C11H28ClN5O	62816	Minor		Inter Info	[136], [137], [138]
D0329		Cholestyramine	C27H47ClN2	137699107	Minor		Inter Info	[140]
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Moderate		Inter Info	[80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[57], [5], [20], [58], [59]
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[122]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[40], [41], [46]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[40], [41], [46]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[40], [41], [46]
D1372		Quinine	C20H24N2O2	3034034	Minor		Inter Info	[139]
Affected excretion pathways
	Altered urine pH					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0886		Lactic acid	C3H6O3	612	Moderate		Inter Info	[124], [125], [126]
D1319		Potassium citrate	C6H5K3O7	13344	Moderate		Inter Info	[124], [125], [126]
D1478		Sodium acetate	C2H3NaO2	517045	Moderate		Inter Info	[124], [125], [126]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[124], [125], [126]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[124], [125], [126]
D1654		Tromethamine	C4H11NO3	6503	Moderate		Inter Info	[124], [125], [126]
Pharmacodynamic additive effects
	Additive neuromuscular blocking effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[48], [49]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[48], [49]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[48], [49]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[48], [49]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[48], [49]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[48], [49]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[48], [49]
	Increased risk of hepatotoxicity					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[26]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[30]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[31]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[64], [65], [66], [5], [20], [67], [68], [69], [70], [71], [72], [73], [74]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[64], [65], [66], [5], [20], [67], [68], [69], [70], [71], [72], [73], [74]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[107]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[64], [65], [66], [5], [20], [67], [68], [69], [70], [71], [72], [73], [74]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[121]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[5], [20], [128], [129], [130]
	Increased risk of hypoglycemia					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[54], [55], [56]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[54], [55], [56]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[54], [55], [56]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[54], [55], [56]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[54], [55], [56]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[54], [55], [56]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[54], [55], [56]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[54], [55], [56]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[54], [55], [56]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[54], [55], [56]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[54], [55], [56]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[54], [55], [56]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[54], [55], [56]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[54], [55], [56]
	Increased risk of nephrotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Major		Inter Info	[27], [28], [29]
D0058		Amiloride	C6H8ClN7O	16231	Minor		Inter Info	[39], [134], [135]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Minor		Inter Info	[39], [134], [135]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Minor		Inter Info	[39], [134], [135]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Minor		Inter Info	[39], [134], [135]
D0704		Furosemide	C12H11ClN2O5S	3440	Minor		Inter Info	[39], [134], [135]
D0978		Mannitol	C6H14O6	6251	Minor		Inter Info	[39], [134], [135]
D1018		Methazolamide	C5H8N4O3S2	4100	Minor		Inter Info	[39], [134], [135]
D1048		Metolazone	C16H16ClN3O3S	4170	Minor		Inter Info	[39], [134], [135]
D1501		Spironolactone	C24H32O4S	5833	Minor		Inter Info	[39], [134], [135]
D0012		Acetazolamide	C4H6N4O3S2	1986	Minor		Inter Info	[39], [134], [135]
D0217		Bumetanide	C17H20N2O5S	2471	Minor		Inter Info	[39], [134], [135]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Minor		Inter Info	[39], [134], [135]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Minor		Inter Info	[39], [134], [135]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Minor		Inter Info	[39], [134], [135]
D0731		Glycerin	C3H8O3	753	Minor		Inter Info	[39], [134], [135]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Minor		Inter Info	[39], [134], [135]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Minor		Inter Info	[39], [134], [135]
D0798		Indapamide	C16H16ClN3O3S	3702	Minor		Inter Info	[39], [134], [135]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Minor		Inter Info	[39], [134], [135]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Minor		Inter Info	[39], [134], [135]
D1611		Torasemide	C16H20N4O3S	41781	Minor		Inter Info	[39], [134], [135]
D1631		Triamterene	C12H11N7	5546	Minor		Inter Info	[39], [134], [135]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[24], [25]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[5], [48], [24], [60], [61]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[75], [20], [76]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[5], [20], [105]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[5], [20], [105]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[20], [48], [24], [133]
	Increased risk of pseudotumor cerebri					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0018		Acitretin	C21H26O3	5284513	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0863		Isotretinoin	C20H28O2	5282379	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1626		Tretinoin	C20H28O2	444795	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1702		Vitamin A	C20H30O	445354	Major		Inter Info	[9], [14], [12], [10], [13], [11], [22], [16], [15], [17], [18], [23], [8], [2], [4], [7], [19], [5], [20], [1], [3], [6], [21]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[20], [32], [33]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[34]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0079		Ampicillin	C16H19N3O4S	6249	Moderate		Inter Info	[10], [35], [36]
D0257		Carbenicillin	C17H18N2O6S	20824	Moderate		Inter Info	[10], [35], [36]
D0480		Dicloxacillin	C19H17Cl2N3O5S	18381	Moderate		Inter Info	[10], [35], [36]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[10], [35], [36]
D1192		Oxacillin	C19H19N3O5S	6196	Moderate		Inter Info	[10], [35], [36]
D1268		Phenoxymethylpenicillin	C16H18N2O5S	6869	Moderate		Inter Info	[10], [35], [36]
D1296		Piperacillin	C23H27N5O7S	43672	Moderate		Inter Info	[10], [35], [36]
D0073		Amoxicillin	C16H19N3O5S	33613	Moderate		Inter Info	[10], [35], [36]
D0141		Bacampicillin	C21H27N3O7S	441397	Moderate		Inter Info	[10], [35], [36]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[106]
D0167		Benzylpenicillin	C16H18N2O4S	5904	Moderate		Inter Info	[10], [35], [36]
D0168		Benzylpenicillin (potassium)	C16H18N2O4S	5904	Moderate		Inter Info	[10], [35], [36]
D0169		Benzylpenicillin (sodium)	C16H18N2O4S	5904	Moderate		Inter Info	[10], [35], [36]
D0369		Cloxacillin	C19H18ClN3O5S	6098	Moderate		Inter Info	[10], [35], [36]
D1044		Meticillin	C17H20N2O6S	6087	Moderate		Inter Info	[10], [35], [36]
D1055		Mezlocillin	C21H25N5O8S2	656511	Moderate		Inter Info	[10], [35], [36]
D1580		Ticarcillin	C15H16N2O6S2	36921	Moderate		Inter Info	[10], [35], [36]

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