Drug General Information (ID: DDI0V527KR)
Drug Name			Porfimer sodium		Drug Info		Tetracycline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antibiotics
Structure

Mechanism of Porfimer sodium-Tetracycline Interaction (Severity Level: Moderate)
Increased risk of photosensitivity reactions Click to Show/Hide Mechanism Graph
Drug Name		Porfimer sodium				Tetracycline
Mechanism		Photosensitivity reactions				Photosensitivity reactions
Key Mechanism Factor 1
		Factor Name		Photosensitivity reactions
		Factor Description		Drug-induced photosensitivity reactions occur when certain photosensitizing drugs cause unexpected sunburn or dermatitis (dry, bumpy or blistering rash) on sun-exposed skin (face, neck, arms, backs of hands, and often lower legs and feet). The rash may or may not be itchy.
Mechanism Description		Increased risk of photosensitivity reactions by the combination of Porfimer sodium and Tetracycline

Recommended Action
Management		Concomitant use of photosensitizing agents with porfimer should be avoided for at least 30 days and maybe up to 90 days or longer depending on patient's hepatic and/or renal function.

References
1	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.