Drug General Information (ID: DDIVT0E2J6)
Drug Name			Tetracycline		Drug Info		Calcium Phosphate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Minerals And Electrolytes/Phosphate Binders
Structure

Mechanism of Tetracycline-Calcium Phosphate Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Tetracycline				Calcium Phosphate
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Calcium Phosphate due to formation of complexes caused by Tetracycline

Recommended Action
Management		The administration of tetracyclines and preparations containing aluminum, magnesium, or calcium should be separated by two to four hours.

References
1	Gotz VP, Ryerson GG "Evaluation of tetracycline on theophylline disposition in patients with chronic obstructive airways disease." Drug Intell Clin Pharm 20 (1986): 694-6. [PMID: 3757782]
2	Nguyen VX, Nix DE, Gillikin S, Schentag JJ "Effect of oral antacid administration on the pharmacokinetics of intravenous doxycycline." Antimicrob Agents Chemother 33 (1989): 434-6. [PMID: 2729939]
3	Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80. [PMID: 1674242]