Drug General Information (ID: DDIIHVFMSP)
Drug Name			Colestipol		Drug Info		Fluvastatin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bile Acid Sequestrants				Statins/Antihyperlipidemic Agents
Structure

Mechanism of Colestipol-Fluvastatin Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Colestipol				Fluvastatin
Mechanism		Anion exchange resin/polymer				Binds to anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Colestipol due to formation of complexes caused by Fluvastatin

Recommended Action
Management		If therapy with both agents is necessary, the HMG-CoA reductase inhibitor should be administered at least 4 hours after the bile acid sequestrant.

References
1	Smith HT, Jokubaitis LA, Troendle AJ, Hwang DS, Robinson WT "Pharmacokinetics of fluvastatin and specific drug interactions." Am J Hypertens 6 (1993): s375-82. [PMID: 8297546]