Drug General Information (ID: DDIR0ES9LC)
Drug Name			Doxycycline		Drug Info		Colestipol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Bile Acid Sequestrants
Structure

Mechanism of Doxycycline-Colestipol Interaction (Severity Level: Minor)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Doxycycline				Colestipol
Mechanism		Binds to anion exchange resin/polymer				Anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Colestipol due to formation of complexes caused by Doxycycline

References
1	Friedman H, Greenblatt DJ, LeDuc BW "Impaired absorption of tetracycline by colestipol is not reversed by orange juice." J Clin Pharmacol 29 (1989): 748-51. [PMID: 2778097]
2	Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS "Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia." Drugs 19 (1980): 161-80. [PMID: 6988203]
3	Product Information. Colestid (colestipol HCI). Pharmacia and Upjohn, Kalamazoo, MI.