Drug General Information (ID: DDIUGYMPZ1)
Drug Name			Colestipol		Drug Info		Indapamide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bile Acid Sequestrants				Antihypertensive Agents
Structure

Mechanism of Colestipol-Indapamide Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Colestipol				Indapamide
Mechanism		Anion exchange resin/polymer				Binds to anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Colestipol due to formation of complexes caused by Indapamide

Recommended Action
Management		Thiazide diuretics should be administered as far apart from colestipol as possible, but at least 1 hour before or 4 hours after colestipol. Patients should be monitored for potentially diminished therapeutic effects, and the thiazide dosage adjusted if necessary.

References
1	Hunninghake DB, King S, LaCroix K "The effect of cholestyramine and colestipol on the absorption of hydrochlorothiazide." Int J Clin Pharmacol Ther Toxicol 20 (1982): 151-4. [PMID: 7076343]
2	Kauffman RE, Azarnoff DL "Effect of colestipol on gastrointestinal absorption of chlorothiazide in man." Clin Pharmacol Ther 14 (1973): 886-90. [PMID: 4729904]
3	Product Information. Colestid (colestipol HCI). Pharmacia and Upjohn, Kalamazoo, MI.