Drug General Information (ID: DDIV8TJXG1)
Drug Name			Colestipol		Drug Info		Fenofibrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bile Acid Sequestrants				Antihyperammonia Agents
Structure

Mechanism of Colestipol-Fenofibrate Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Colestipol				Fenofibrate
Mechanism		Anion exchange resin/polymer				Binds to anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Colestipol due to formation of complexes caused by Fenofibrate

Recommended Action
Management		Fenofibrate/fenofibric acid should be taken at least 1 hour before or 4 to 6 hours after the bile acid sequestrant.

References
1	Canadian Pharmacists Association.
2	Product Information. Tricor (fenofibrate). Abbott Pharmaceutical, Abbott Park, IL.
3	Product Information. Trilipix (fenofibric acid). Abbott Pharmaceutical, Abbott Park, IL.