Details of Drug

Drug General Information (ID: D0642)
Drug Name	Fenofibrate
Drug Type	Small molecule
Drug Synonymous	Ankebin; Antara; Controlip; Durafenat; Elasterate; Elasterin; FNF; Fenobeta; Fenobrate; Fenofanton; Fenofibrato; Fenofibratum; Fenogal; Fenoglide; Fenomax; Fenotard; Finofibrate; Fulcro; Lipanthyl; Lipantil; Liparison; Lipidex; Lipidil; Lipifen; Lipirex; Lipoclar; Lipofen; Lipofene; Liposit; Lipsin; Lofibra; Luxacor; Nolipax; Pharmavit; Phenofibrate; Procetofen; Procetofene; Proctofene; Protolipan; Secalip; Sedufen; Supralip; Tricor; Triglide; AbZ Brand of Procetofen; Abbott Brand of Procetofen; Aliud Brand of Procetofen; Antara Micronized Procetofen; Anto Brand of Procetofen; Apo Feno Micro; Apo Fenofibrate; Apotex Brand of Procetofen; Azupharma Brand of Procetofen; Betapharm Brand of Procetofen; Bouchara Brand of Procetofen; Ct Arzneimittel Brand of Procetofen; Fenofibrat AL; Fenofibrat AZU; Fenofibrat AbZ; Fenofibrat FPh; Fenofibrat Heumann; Fenofibrat Hexal; Fenofibrat Stada; Fenofibrat ratiopharm; Fenofibrat von ct; Fenofibrate Debat; Fenofibrate MSD; Fournier Brand of Procetofen; GNR Pharma Brand of Procetofen; Gate Brand of Procetofen; Gen Fenofibrate; Genpharm Brand of Procetofen; Heumann Brand of Procetofen; Hexal Brand of Procetofen; Knoll Brand of Procetofen; Lichtenstein Brand of Procetofen; Lipidil Micro; Lipidil Supra; Lipidil Ter; MTW Brand of Procetofen; MTW Fenofibrat; Merck dura Brand of Procetofen; Novartis Brand of Procetofen; Novo Fenofibrate; Novopharm Brand of Procetofen; Nu Fenofibrate; Nu Pharm Brand of Procetofen; PMS Fenofibrate Micro;Pharmascience Brand of Procetofen; Procetofen Reliant Brand; Q Pharm Brand of Procetofen; Ratiopharm Brand of Procetofen; Reliant Brand of Procetofen; Schering Plough Brand of Procetofen; Stadapharm Brand of Procetofen; United Drug Brand of Procetofen; F 6020; LF 178; LF178; AZU, Fenofibrat; Antara (TN); Antara (micronized); Apo-Fenofibrate; CIP-Fenofibrate; Ct-Arzneimittel Brand of Procetofen; Debat, Fenofibrate; FENOFIBRATE (MICRONIZED); Fenofibrat-ratiopharm; Fenofibrate IDD-P; Fenofibrate [INN:BAN]; Fenofibrato [INN-Spanish]; Fenofibratum [INN-Latin]; Fenogal (TN); GNR-Pharma Brand of Procetofen; GRS-027; Gen-Fenofibrate; Heumann, Fenofibrat; Hexal, Fenofibrat; LCP-Feno; LCP-FenoChol; LF-178; Lipanthyl (TN); Lipantil (TN); Lipidil (TN); Lipidil-Ter; Lipofen (TN); Lofibra (TN); MTW-Fenofibrat; Micronized Procetofen, Antara; Novo-Fenofibrate; Nu-Fenofibrate; Nu-Pharm Brand of Procetofen; PMS-Fenofibrate Micro; Procetofen, Antara Micronized; Q-Pharm Brand of Procetofen; Schering-Plough Brand of Procetofen; Stada, Fenofibrat; TRICOR (MICRONIZED); Tricor (TN); Triglide (TN); Trilipix (TN); Apo-Feno-Micro; Fenocor-67 (TN); Fenofibrate (JAN/INN); Isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate; Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate; Isopropyl 2-(p-(p-chlorobenzoyl)phenoxy)-2-methylpropionate Click to Show/Hide
Disease Class	5C80: Hyper-lipoproteinaemia
Therapeutic Class	Antihyperammonia Agents
Structure
Structure	3D Structure		2D Structure
Formula	C20H21ClO4
InChI	1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
InChIKey	YMTINGFKWWXKFG-UHFFFAOYSA-N
Canonical SMILES	CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
External Link
	Pubchem ID	3339
	CAS Number	49562-28-9
	CHEBI ID	5001
	TTD ID	D07XGR
	INTEDE ID	DR0688
	VARIDT ID	DR00415

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM003 Complex formation BM013 Competitive binding of plasma proteins BM017 CYP450 enzyme inhibition BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM072 Increased risk of nephrotoxicity BM075 Increased risk of photosensitivity reactions BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Fenofibrate
Affected gastrointestinal absorption
	Complex formation					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[7], [13], [14]
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[7], [13], [14]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[7], [5], [8]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[9], [10], [7], [5], [11], [12], [8], [13], [14]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[9], [10], [7], [5], [11], [12], [8], [13], [14]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 56
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[4], [5], [6]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[4], [20]
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[4], [5], [6]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[4], [5], [6]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[4], [5], [6]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[4], [5], [6]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[133]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[4], [5], [6]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[4], [5], [6]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[4], [5], [6]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[4], [5], [6]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[4], [5], [6]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[4], [5], [6]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[161], [162], [163], [164], [165], [166], [167], [168], [169]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[4], [5], [6]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[170]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[5], [171]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[4], [5], [6]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[4], [5], [6]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[4], [5], [6]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[180]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[181]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[4], [5], [6]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[4], [5], [6]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[5], [186], [187]
D1350		Proguanil	C11H16ClN5	6178111	Moderate		Inter Info	[4], [5], [6]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[4], [5], [6]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[4], [5], [6]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[194]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[4], [5], [6]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[4], [5], [6]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[4], [5], [6]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[4], [5], [6]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[4], [5], [6]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[4], [5], [6]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[4], [5], [6]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[4], [5], [6]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[196], [197]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[4], [5], [6]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[4], [5], [6]
D1133		Nicotine	C10H14N2	89594	Moderate		Inter Info	[4], [5], [6]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[4], [5], [6]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[4], [5], [6]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[4], [5], [6]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[4], [5], [6]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[4], [5], [6]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[4], [5], [6]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[4], [5], [6]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[4], [5], [6]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[204], [205], [206]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[4], [5], [6]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[4], [5], [6]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[207], [208]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[4], [5], [6]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[4], [5], [6]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[7], [15], [16]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[17]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[18]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[19]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[7], [15], [16]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[122], [123], [124], [4], [5], [125], [126], [127], [128], [129], [130], [131], [132]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[134]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[155], [156]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[4], [5], [157]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[122], [123], [124], [4], [5], [125], [126], [127], [128], [129], [130], [131], [132]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[158]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[159]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[122], [123], [124], [4], [5], [125], [126], [127], [128], [129], [130], [131], [132]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[5], [160]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[172]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[182], [183], [184], [185]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[4], [5], [188], [189], [190]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[5], [193]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[182], [183], [184], [185]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[182], [183], [184], [185]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[5], [195]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[198]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[122], [123], [124], [4], [5], [125], [126], [199], [128], [129], [130], [131], [132]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[202], [203]
	Increased risk of hypoglycemia					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[28], [85], [102]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[28], [85], [102]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [173], [32], [33], [34], [35], [36], [37], [38], [39], [41], [42], [43], [45], [46], [47], [48], [50], [51], [52], [54], [56], [57], [58], [59], [60], [61], [62], [63], [64], [66], [69], [71], [72], [73], [76], [77], [79], [80], [81], [83], [174], [85], [175], [176], [90], [177], [178], [96], [98], [99], [100], [102], [104], [106], [108], [109], [113], [114], [115], [116], [179], [117], [118], [120], [121]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [173], [32], [33], [34], [35], [36], [37], [38], [39], [41], [42], [43], [45], [46], [47], [48], [50], [51], [52], [54], [56], [57], [58], [59], [60], [61], [62], [63], [64], [66], [69], [71], [72], [73], [76], [77], [79], [80], [81], [83], [174], [85], [175], [176], [90], [177], [178], [96], [98], [99], [100], [102], [104], [106], [108], [109], [113], [114], [115], [116], [179], [117], [118], [120], [121]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [173], [32], [33], [34], [35], [36], [37], [38], [39], [41], [42], [43], [45], [46], [47], [48], [50], [51], [52], [54], [56], [57], [58], [59], [60], [61], [62], [63], [64], [66], [69], [71], [72], [73], [76], [77], [79], [80], [81], [83], [174], [85], [175], [176], [90], [177], [178], [96], [98], [99], [100], [102], [104], [106], [108], [109], [113], [114], [115], [116], [179], [117], [118], [120], [121]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [173], [32], [33], [34], [35], [36], [37], [38], [39], [41], [42], [43], [45], [46], [47], [48], [50], [51], [52], [54], [56], [57], [58], [59], [60], [61], [62], [63], [64], [66], [69], [71], [72], [73], [76], [77], [79], [80], [81], [83], [174], [85], [175], [176], [90], [177], [178], [96], [98], [99], [100], [102], [104], [106], [108], [109], [113], [114], [115], [116], [179], [117], [118], [120], [121]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [85], [102]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [85], [102]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [85], [102]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [85], [102]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [85], [102]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [85], [102]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [173], [32], [33], [34], [35], [36], [37], [38], [39], [41], [42], [43], [45], [46], [47], [48], [50], [51], [52], [54], [56], [57], [58], [59], [60], [61], [62], [63], [64], [66], [69], [71], [72], [73], [76], [77], [79], [80], [81], [83], [174], [85], [175], [176], [90], [177], [178], [96], [98], [99], [100], [102], [104], [106], [108], [109], [113], [114], [115], [116], [179], [117], [118], [120], [121]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[28], [85], [102]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121]
	Increased risk of nephrotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[9], [7], [5], [154], [12], [13], [14]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[200], [5], [201]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0303		Cerivastatin	C26H34FNO5	446156	Major		Inter Info	[1], [2], [3]
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[1], [2], [3]
D0686		Fluvastatin	C24H26FNO4	446155	Major		Inter Info	[1], [2], [3]
D1301		Pitavastatin	C25H24FNO4	5282452	Major		Inter Info	[1], [2], [3]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Major		Inter Info	[1], [2], [3]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[1], [2], [3]
D1329		Pravastatin	C23H36O7	54687	Major		Inter Info	[1], [2], [3]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[1], [2], [3]
D0421		Daptomycin	C72H101N17O26	16134395	Moderate		Inter Info	[5]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[191], [192]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[191], [192]

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84	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
85	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
86	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
87	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
88	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
89	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
90	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
91	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
92	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
93	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
94	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
95	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
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128	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
129	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
130	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
131	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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147	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
148	Product Information. Kapidex (dexlansoprazole). Takeda Pharmaceuticals America, Lincolnshire, IL.
149	Product Information. Plavix (clopidogrel). Bristol-Myers Squibb, Princeton, NJ.
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156	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
157	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
158	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
159	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
160	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
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170	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
171	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
172	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
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175	Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
176	Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
177	Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
178	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
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180	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
181	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
182	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
183	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
184	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
185	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
186	Product Information. Esbriet (pirfenidone). Intermune Inc, Brisbane, CA.
187	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
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191	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
192	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.
193	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
194	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
195	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
196	Karonen T, Filppula A, Laitila J, Niemi M, Neuvonen PJ, Backman JT "Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast." Clin Pharmacol Ther (2010):. [PMID: 20592724]
197	Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
198	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
199	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine. [PMID: 26722167]
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201	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
202	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
203	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
204	Miners JO, Rees DLP, Valente L, Veronese ME, Birkett DJ "Human hepatic cytochrome p450 2c9 catalyzes the rate-limiting pathway of torsemide metabolism." J Pharmacol Exp Ther 272 (1995): 1076-81. [PMID: 7891318]
205	Product Information. Demedex (torsemide). Boehringer Mannheim, Gaithersburg, MD.
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207	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
208	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.

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