Drug General Information (ID: DDIRL3O8GY)
Drug Name			Trazodone		Drug Info		Anisindione		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidepressants				Anticoagulants
Structure

Mechanism of Trazodone-Anisindione Interaction (Severity Level: Minor)
Antagonize the effect of antithrombotic agents Click to Show/Hide Mechanism Graph
Drug Name		Trazodone				Anisindione
Mechanism		Decrease the hypoprothrombinemic effect of vitamin K antagonist				Vitamin K antagonist
Key Mechanism Factor 1
		Factor Name		Antithrombotic agents
		Factor Description		The beneficial effects of antithrombotic agents are reduced, leading to an increased risk of thromboembolism, stroke and/or myocardial infarction.
Mechanism Description		Antagonize the effect of Anisindione when combined with Trazodone

References
1	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
2	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
3	Hardy JL, Sirois A "Reduction of prothrombin and partial thromboplastin times with trazodone." Can Med Assoc J 135 (1986): 1372