Details of Drug

Drug General Information (ID: D0342)
Drug Name	Cisapride
Drug Type	Small molecule
Drug Synonymous	cisapride; Propulsid; Prepulsid; Syspride; Pridesia; Risamal; Acenalin; Alimix; Propulsin; Propulsid Quicksolv; Enteropride; Kinestase; 81098-60-4; Cisawal; Vomiprid; Colinorm; Cisapron; Vomipride; Unipride; Kaudalit; Alipride; Acpulsif; Rapulid; Cipride; Pulsid; Esorid; Dispep; Presid; Unamol; Guptro; Alimix Forte; Cisapridum [Latin]; Cisaprida [Spanish]; R-51619; Cisapridum [INN-Latin]; R 51619; Cisaprida [INN-Spanish]; 104860-73-3; DCSUBABJRXZOMT-UHFFFAOYSA-N; T 1341; DSSTox_CID_2825; Acenalin; Cisaprida; Cisapridum; Risamol; Prepulsid (TN); Propulsid (TN); Cisapride (USAN/INN); Cisapride [USAN:BAN:INN:JAN]; Cis-4-Amino-5-chloro-N-(1-(3-(p-fluorophenoxy)propyl)-3-methoxy-4-piperidyl)-o-anisamide; (+-)-Cisapride; 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide; 4-amino-5-chloro-N-[1-{3-[(4-fluorophenyl)oxy]propyl}-3-(methyloxy)piperidin-4-yl]-2-(methyloxy)benzamide; 4-amino-5-chloro-N-{1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide; E-1454 Click to Show/Hide
Disease Class	DA22: Gastro-oesophageal reflux disease; DE2Z: Digestive system disease
Therapeutic Class	Gastrointestinal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C23H29ClFN3O4
InChI	1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)/t20-,22+/m1/s1
InChIKey	DCSUBABJRXZOMT-IRLDBZIGSA-N
Canonical SMILES	COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
External Link
	Pubchem ID	6917698
	CAS Number	81098-60-4
	CHEBI ID	3720
	TTD ID	D0BD8D
	INTEDE ID	DR0331
	VARIDT ID	DR00794

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM097 Antagonize the effect of prokinetic agents
Relation Graph

Full list of drugs interacting with Cisapride
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[133]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[5], [170]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[171], [172], [173]
D1381		Ranitidine	C13H22N4O3S	3001055	Minor		Inter Info	[181]
D1089		Morphine	C17H19NO3	5288826	Minor		Inter Info	[133], [183]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 54
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D0337		Cimetidine	C10H16N6S	2756	Major		Inter Info	[9], [10], [11], [7], [12], [13], [16], [8], [4], [5]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[7], [23], [5]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[24], [25]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[10], [11], [7], [28], [12], [13], [8], [29], [30], [14], [4], [31], [32], [33], [34], [35], [23], [36], [5], [37], [38], [39]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[40], [2], [3], [41]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[42], [9], [10], [11], [7], [12], [13], [43], [8], [14], [4], [44], [45], [5], [46], [6], [47], [48], [49]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[10], [50], [11], [7], [12], [13], [8], [4], [51], [5], [52], [53], [54], [48]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[9], [10], [50], [11], [7], [12], [13], [43], [8], [14], [4], [44], [55], [6], [47]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[56], [57], [58]
D0416		Danazol	C22H27NO2	28417	Major		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[10], [11], [7], [28], [12], [13], [8], [29], [30], [14], [4], [31], [32], [33], [34], [35], [23], [36], [5], [37], [38], [39]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[10], [12], [13]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[9], [4], [15]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[10], [11], [7], [12], [13], [8], [4], [60], [61]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[10], [11], [7], [28], [12], [13], [8], [29], [30], [14], [4], [31], [32], [33], [34], [35], [23], [36], [5], [37], [38], [39]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[24], [25]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[10], [50], [11], [7], [12], [13], [8], [4], [51], [5], [52], [53], [54], [48]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[9], [10], [2], [11], [7], [12], [8], [4], [67], [68], [69], [5], [70], [71], [72]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[9], [10], [2], [11], [7], [12], [8], [4], [67], [68], [69], [5], [70], [71], [72]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[11], [5], [52]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[10], [50], [11], [7], [12], [13], [8], [4], [51], [5], [52], [53], [54], [48]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[10], [50], [11], [7], [12], [13], [8], [4], [51], [5], [52], [53], [54], [48]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[9], [10], [2], [11], [7], [12], [8], [4], [67], [68], [69], [5], [70], [71], [72]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[10], [11], [7], [28], [12], [13], [8], [29], [30], [14], [4], [31], [32], [33], [34], [35], [23], [36], [5], [37], [38], [39]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[9], [4], [15]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[11], [5], [46]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[11], [5], [52]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[9], [4], [15]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[42], [9], [10], [11], [7], [12], [13], [43], [8], [14], [4], [44], [45], [5], [46], [6], [47], [48], [49]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[9], [10], [2], [11], [7], [12], [8], [4], [67], [68], [69], [5], [70], [71], [72]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[10], [50], [11], [7], [12], [13], [8], [4], [51], [108], [54]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[10], [11], [7], [28], [12], [13], [8], [29], [30], [14], [4], [31], [32], [33], [34], [35], [23], [36], [5], [37], [38], [39]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[10], [11], [7], [28], [12], [13], [8], [29], [30], [14], [4], [31], [32], [33], [34], [35], [23], [36], [5], [37], [38], [39]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[10], [11], [7], [28], [12], [13], [8], [29], [30], [14], [4], [31], [32], [33], [34], [35], [23], [36], [5], [37], [38], [39]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[9], [10], [2], [11], [7], [12], [8], [4], [67], [68], [69], [5], [70], [71], [72]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[116]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[131], [132]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[141]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[142]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[2], [3], [143]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[9], [10], [11], [7], [12], [8], [4], [67], [147], [5]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[2], [3]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[9], [10], [11], [7], [12], [13], [8], [14], [4], [5], [15]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[3], [175]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[9], [10], [11], [7], [12], [8], [4], [67], [147], [5]
	CYP450 enzyme induction					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[3], [113], [114]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[115]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[129]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3], [130]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[2], [137]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[138]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[139]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[146]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[2], [148], [149], [150], [151], [152]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[153], [154], [155]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[156], [157]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[168], [169]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[2], [3], [176], [177]
Pharmacodynamic additive effects
	Increased risk of prolong QT interval					Drug Num: 141
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[1], [2], [5]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[1], [2], [5]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[1], [2], [5]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3], [59]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[1], [2], [5]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[1], [2], [5]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[1], [2], [5]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[1], [2], [5]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[1], [2], [5]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[1], [2], [5]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[1], [2], [5]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1], [2], [5]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[1], [2], [5]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[75], [76], [77]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1], [2], [5]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[1], [2], [5]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1], [2], [5]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[1], [2], [5]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1], [2], [5]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[1], [2], [5]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3], [105], [106], [107], [63]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[109], [110]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2], [3], [111], [112], [107]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[2], [3], [120], [121], [122], [123], [124], [125]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[2], [3], [140]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[144], [145]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[158], [159], [160], [161], [162], [163], [164], [165], [166], [167]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[2], [178], [179], [180]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[1], [2], [182]
	Increased risk of ventricular arrhythmias					Drug Num: 43
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Major		Inter Info	[7], [8], [5]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Major		Inter Info	[5]
D0012		Acetazolamide	C4H6N4O3S2	1986	Major		Inter Info	[5]
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[17], [3], [18], [19], [20], [4], [21], [22]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[26], [27]
D0217		Bumetanide	C17H20N2O5S	2471	Major		Inter Info	[5]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Major		Inter Info	[5]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Major		Inter Info	[7], [8], [5]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Major		Inter Info	[7], [8], [5]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[1], [2], [3], [62], [63]
D0704		Furosemide	C12H11ClN2O5S	3440	Major		Inter Info	[5]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Major		Inter Info	[5]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Major		Inter Info	[7], [8], [5]
D0798		Indapamide	C16H16ClN3O3S	3702	Major		Inter Info	[5]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[64], [65], [66]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[3], [73], [74]
D1018		Methazolamide	C5H8N4O3S2	4100	Major		Inter Info	[5]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[64], [65], [66]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Major		Inter Info	[78], [79], [80]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Major		Inter Info	[78], [79], [80]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Major		Inter Info	[7], [8], [5]
D1488		Sodium sulfate	Na2O4S	24436	Major		Inter Info	[78], [79], [80]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[64], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [65], [99], [100], [101], [102], [66], [103], [104]
D1048		Metolazone	C16H16ClN3O3S	4170	Major		Inter Info	[5]
D1611		Torasemide	C16H20N4O3S	41781	Major		Inter Info	[7], [8], [5]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[64], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [117], [118], [93], [94], [95], [96], [97], [119], [98], [65], [99], [100], [101], [102], [66], [103], [104]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[1], [2], [3], [126], [127], [128]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[1], [2], [3], [126], [127], [128]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[1], [2], [3], [134], [135], [136]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[64], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [117], [118], [93], [94], [95], [96], [97], [119], [98], [65], [99], [100], [101], [102], [66], [103], [104]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[2], [3], [128]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[1], [2], [3], [126], [127], [128]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[2], [3], [128]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[117], [99], [102]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1], [2], [3], [126], [127], [128]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[1], [2], [3], [126], [127], [128]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[64], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [117], [118], [93], [94], [95], [96], [97], [119], [98], [65], [99], [100], [101], [102], [66], [103], [104]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[117], [99], [102]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[2], [3], [128]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[1], [2], [3], [134], [135], [136]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[2], [3], [174]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[117], [99], [102]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[1], [2], [3], [126], [127], [128]
Pharmacodynamic antagonistic effects
	Antagonize the effect of prokinetic agents					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[5]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[5]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[5]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[5]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[7], [8], [5]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[7], [8], [5]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[5]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[5]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[5]

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