Drug General Information (ID: DDI6APRVMD)
Drug Name			Cisapride		Drug Info		Ranitidine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gastrointestinal Agents				Antiulcer Agents
Structure

Mechanism of Cisapride-Ranitidine Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Cisapride				Ranitidine
Mechanism		Increase gastrointestinal motility				Absorption is influenced by gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Ranitidine due to GI dynamics variation caused by Cisapride

References
1	Rowbotham DJ, Milligan K, McHugh P "Effect of single doses of cisapride and ranitidine administered simultaneously on plasma concentrations of cisapride and ranitidine." Br J Anaesth 67 (1991): 302-5. [PMID: 1911017]