Drug General Information (ID: DDIIUW9PZG)
Drug Name			Atropine		Drug Info		Cisapride		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Gastrointestinal Agents
Structure

Mechanism of Atropine-Cisapride Interaction (Severity Level: Moderate)
Antagonize the effect of prokinetic agents Click to Show/Hide Mechanism Graph
Drug Name		Atropine				Cisapride
Mechanism		Decrease gastrointestinal motility				Increase gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Prokinetic agents
		Factor Description		The efficacy of prokinetic agents may be reduced, leading to delayed gastric emptying and worsening esophageal reflux.
Mechanism Description		Antagonize the effect of Cisapride when combined with Atropine

Recommended Action
Management		This combination should be avoided.

References
1	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.