Drug General Information (ID: DDI37A6T4K)
Drug Name			Alfuzosin		Drug Info		Cisapride		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Gastrointestinal Agents
Structure

Mechanism of Alfuzosin-Cisapride Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Alfuzosin				Cisapride
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Alfuzosin and Cisapride

Recommended Action
Management		Coadministration of cisapride with other drugs that can prolong the QT interval is considered contraindicated.

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
5	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
6	Trinkle R "Comment: syncopal episodes associated with cisapride." Ann Pharmacother 33 (1999): 251. [PMID: 10084425]