Drug General Information (ID: DDIG05HZ4U)
Drug Name			Morphine		Drug Info		Cisapride		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Gastrointestinal Agents
Structure

Mechanism of Morphine-Cisapride Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Morphine				Cisapride
Mechanism		Absorption is influenced by gastrointestinal motility				Increase gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Morphine due to GI dynamics variation caused by Cisapride

References
1	Greiff JMC, Rowbotham D "Pharmacokinetic drug interactions with gastrointestinal motility modifying agents." Clin Pharmacokinet 27 (1994): 447-61. [PMID: 7882635]
2	Rowbotham DJ, Milligan K, McHugh P "Effect of cisapride on morphine absorption after oral administration of sustained-release morphine." Br J Anaesth 67 (1991): 421-5. [PMID: 1718364]