Drug General Information (ID: DDIEXVTSZW)
Drug Name			Cisapride		Drug Info		Propantheline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gastrointestinal Agents				Antispasmodics
Structure

Mechanism of Cisapride-Propantheline Interaction (Severity Level: Moderate)
Antagonize the effect of prokinetic agents Click to Show/Hide Mechanism Graph
Drug Name		Cisapride				Propantheline
Mechanism		Increase gastrointestinal motility				Decrease gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Prokinetic agents
		Factor Description		The efficacy of prokinetic agents may be reduced, leading to delayed gastric emptying and worsening esophageal reflux.
Mechanism Description		Antagonize the effect of Propantheline when combined with Cisapride

Recommended Action
Management		This combination should be avoided.

References
1	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.