Details of Drug-Drug Interaction
| Drug General Information (ID: DDIN37OCS1) | |||||||||
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| Drug Name | Cisapride | Drug Info | Diazepam | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Gastrointestinal Agents | Benzodiazepine Anticonvulsants | |||||||
| Structure | |||||||||
| Mechanism of Cisapride-Diazepam Interaction (Severity Level: Moderate) | |||||||||
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| Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Cisapride | Diazepam | |||||||
| Mechanism | Increase gastrointestinal motility | Absorption is influenced by gastrointestinal motility | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastrointestinal Motility | ||||||||
| Factor Description | Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | It is recommended that patients be monitored for excessive CNS depression during concomitant therapy. Patients should be advised to report prolonged or excessive sedation to their physician. | ||||||||
| References | |||||||||||||||||||
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| 1 | Greiff JMC, Rowbotham D "Pharmacokinetic drug interactions with gastrointestinal motility modifying agents." Clin Pharmacokinet 27 (1994): 447-61. [PMID: 7882635] | ||||||||||||||||||