Drug General Information (ID: DDI1CJNOZ6)
Drug Name			Cisapride		Drug Info		Doxepin (topical)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gastrointestinal Agents				Antidepressants
Structure

Mechanism of Cisapride-Doxepin (topical) Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Cisapride				Doxepin (topical)
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Cisapride and Doxepin (topical)

Recommended Action
Management		Coadministration of cisapride with other drugs that can prolong the QT interval is considered contraindicated.

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.