Drug General Information (ID: DDI5RFLGCU)
Drug Name			Cisapride		Drug Info		Clidinium		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gastrointestinal Agents				Analgesics
Structure

Mechanism of Cisapride-Clidinium Interaction (Severity Level: Moderate)
Antagonize the effect of prokinetic agents Click to Show/Hide Mechanism Graph
Drug Name		Cisapride				Clidinium
Mechanism		Increase gastrointestinal motility				Decrease gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Prokinetic agents
		Factor Description		The efficacy of prokinetic agents may be reduced, leading to delayed gastric emptying and worsening esophageal reflux.
Mechanism Description		Antagonize the effect of Clidinium when combined with Cisapride

Recommended Action
Management		This combination should be avoided.

References
1	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.