Drug General Information (ID: DDI549N1WV)
Drug Name			Cisapride		Drug Info		Mepenzolate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gastrointestinal Agents				Parasympatholytics
Structure

Mechanism of Cisapride-Mepenzolate Interaction (Severity Level: Moderate)
Antagonize the effect of prokinetic agents Click to Show/Hide Mechanism Graph
Drug Name		Cisapride				Mepenzolate
Mechanism		Increase gastrointestinal motility				Decrease gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Prokinetic agents
		Factor Description		The efficacy of prokinetic agents may be reduced, leading to delayed gastric emptying and worsening esophageal reflux.
Mechanism Description		Antagonize the effect of Mepenzolate when combined with Cisapride

Recommended Action
Management		This combination should be avoided.

References
1	Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57. [PMID: 10668858]
2	Lewin MB, Bryant RM, Fenrich AL, Grifka RG "Cisapride-induced long QT interval." J Pediatr 128 (1996): 279-81. [PMID: 8636830]
3	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.