Details of Drug

Drug General Information (ID: D1480)
Drug Name	Sodium bicarbonate
Drug Type	Small molecule
Drug Synonymous	Acidosan; Colovage; Glycoprep; Golytely; Jusonin; Meylon; Natriumhydrogenkarbonat; Natron; Neut; Nulytely; Soludal; BSS plus; Baking soda; Bicarbonate of soda; Carbonic acid monosodium salt; Gripe water; Lithium bicarbonate; Monosodium hydrogen carbonate; Natrii hydrogencarbonas; Natrium bicarbonicum; Natrium hydrogencarbonicum; Natrum bicarbonicum; Sandoz sodium bicarbonate; Sel De vichy; Soda Mint; Sodium acid carbonate; Sodium bicarbonate in plastic container; Sodium bicarbonate liquid concentrate; Sodium bicarbonate solution; Sodium hydrocarbonate; Sodium hydrogen carbonate; Sodium hydrogencarbonate; NaHCO3; Bicarbonate, Sodium; Carbonic acid, monosodium salt; Co-lav; Col-evac; Go-evac; Hema BP-38; Hydrogen Carbonate, Sodium; Meylon (TN); Neut (TN); Peg-lyte; Soda (van); Soda, Baking; Sodium bicarbonate [USAN:JAN]; Carbonic acid sodium salt (1:1); E-Z-EM Prep Lyte; Sodium bicarbonate (1:1); Sodium bicarbonate (JP15/USP); Sodium carbonate (Na(HCO3)); 800 Sodium Bicarbonate Powder Click to Show/Hide
Disease Class	5C73: Acidosis
Therapeutic Class	Antidiarrheals
Structure
Structure	3D Structure		2D Structure
Formula	CHNaO3
InChI	1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChIKey	UIIMBOGNXHQVGW-UHFFFAOYSA-M
Canonical SMILES	C(=O)(O)[O-].[Na+]
External Link
	Pubchem ID	516892
	CAS Number	144-55-8
	CHEBI ID	32139
	TTD ID	D02FLB
	VARIDT ID	DR00038

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM001 Altered gastrointestinal dynamics BM003 Complex formation BM004 Adsorption BM005 Altered gastric pH BM009 Altered absorption (Unspecific) BM014 Interference of cell/tissue uptake BM029 Altered urine pH BM082 Increased risk of hypernatremia
Relation Graph

Full list of drugs interacting with Sodium bicarbonate
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D0356		Clobazam	C16H13ClN2O2	2789	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D0362		Clonazepam	C15H10ClN3O3	2802	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Minor		Inter Info	[98], [99], [102]
D0473		Diazepam	C16H13ClN2O	3016	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D0604		Estazolam	C16H11ClN4	3261	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D0679		Flurazepam	C21H23ClFN3O	3393	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D0748		Halazepam	C17H12ClF3N2O	31640	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D1060		Midazolam	C18H13ClFN3	4192	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D1197		Oxazepam	C15H11ClN2O2	4616	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D1367		Quazepam	C17H11ClF4N2S	4999	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D1547		Temazepam	C16H13ClN2O2	5391	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D1632		Triazolam	C17H12Cl2N4	5556	Minor		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
	Complex formation					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0515		Dolutegravir	C20H19F2N3O5	54726191	Major		Inter Info	[1]
D0491		Digoxin	C41H64O14	2724385	Minor		Inter Info	[121], [122], [123], [124], [125], [126], [127], [128], [129]
D0490		Digitoxin	C41H64O13	441207	Minor		Inter Info	[121], [122], [123], [124], [125], [126], [127], [128], [129]
	Adsorption					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[24]
D1350		Proguanil	C11H16ClN5	6178111	Moderate		Inter Info	[24], [30]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[40]
D1366		Pyrimethamine	C12H13ClN4	4993	Moderate		Inter Info	[24], [30]
	Altered gastric pH					Drug Num: 64
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[2]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[19], [20]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[21], [22], [23]
D0278		Cefditoren	C19H18N6O5S3	9870843	Moderate		Inter Info	[25]
D0297		Cefuroxime	C16H16N4O8S	5479529	Moderate		Inter Info	[26], [27], [28], [29]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[32]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[40], [24], [41], [42]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[43], [44], [45], [46], [47]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[43], [44], [48], [49], [24], [50], [51], [47]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[54], [55], [56], [57]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[54], [55], [56], [57]
D1218		Pancrelipase	C8H8Na2O5	8519	Moderate		Inter Info	[40], [24], [30]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[61]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[62]
D0141		Bacampicillin	C21H27N3O7S	441397	Moderate		Inter Info	[26], [29]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[24]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[24], [63]
D0229		Cabotegravir	C19H17F2N3O5	54713659	Moderate		Inter Info	[49]
D0288		Cefpodoxime	C15H17N5O6S2	6335986	Moderate		Inter Info	[26], [27], [28], [29]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[64]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[40], [24], [67], [68], [69], [70], [71]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[72]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[81]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[40], [24]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[24], [82], [83], [84], [85], [86]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[87]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[88]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[89]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[94]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[95], [96]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D0156		Benazepril	C24H28N2O5	5362124	Minor		Inter Info	[106]
D0172		Betamethasone	C22H29FO5	9782	Minor		Inter Info	[107], [108], [109]
D0254		Captopril	C9H15NO3S	44093	Minor		Inter Info	[106]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[110], [107], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120]
D0453		Dexamethasone	C22H29FO5	5743	Minor		Inter Info	[107], [108], [109]
D0539		Duloxetine	C18H19NOS	60835	Minor		Inter Info	[130]
D0567		Enalapril	C20H28N2O5	5388962	Minor		Inter Info	[106]
D0636		Famotidine	C8H15N7O2S3	5702160	Minor		Inter Info	[110], [107], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120]
D0671		Fludrocortisone	C21H29FO5	31378	Minor		Inter Info	[107], [108], [109]
D0695		Fosinopril	C30H46NO7P	55891	Minor		Inter Info	[106]
D0773		Hydrocortisone	C21H30O5	5754	Minor		Inter Info	[107], [108], [109]
D0918		Levodopa	C9H11NO4	6047	Minor		Inter Info	[132], [133], [134], [135]
D0938		Lisinopril	C21H31N3O5	5362119	Minor		Inter Info	[106]
D1041		Methylprednisolone	C22H30O5	6741	Minor		Inter Info	[107], [108], [109]
D1082		Moexipril	C27H34N2O7	91270	Minor		Inter Info	[106]
D1109		Naproxen	C14H14O3	156391	Minor		Inter Info	[139], [140]
D1151		Nizatidine	C12H21N5O2S2	3033637	Minor		Inter Info	[110], [107], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120]
D1256		Perindopril	C19H32N2O5	107807	Minor		Inter Info	[106]
D1332		Prednisolone	C21H28O5	5755	Minor		Inter Info	[107], [108], [109]
D1334		Prednisone	C21H26O5	5865	Minor		Inter Info	[107], [108], [109]
D1369		Quinapril	C25H30N2O5	54892	Minor		Inter Info	[106]
D1379		Ramipril	C23H32N2O5	5362129	Minor		Inter Info	[106]
D0133		Axitinib	C22H18N4OS	6450551	Minor		Inter Info	[141]
D1313		Ponatinib	C29H27F3N6O	24826799	Minor		Inter Info	[40], [142]
D1701		Vismodegib	C19H14Cl2N2O3S	24776445	Minor		Inter Info	[40], [24], [143]
D1581		Ticlopidine	C14H14ClNS	5472	Minor		Inter Info	[144]
D1618		Trandolapril	C24H34N2O5	5484727	Minor		Inter Info	[106]
D1628		Triamcinolone	C21H27FO6	31307	Minor		Inter Info	[107], [108], [109]
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[33]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1906		Thallous Chloride	ClTl	24642	Moderate		Inter Info	[40], [90], [91]
Affected excretion pathways
	Altered urine pH					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[10], [11], [12]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[13], [14], [15], [16], [17], [18]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[13], [14], [15], [16], [17], [18]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[30], [31]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[34], [35], [36]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[34], [35], [36]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[37], [38], [39]
D0580		Ephedrine (nasal)	C10H15NO	9294	Moderate		Inter Info	[37], [38], [39]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[30], [31]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[30], [31]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[52]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[53]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[34], [35], [36]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[30], [31]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[30], [31]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[30], [31]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[30], [31]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[34], [35], [36]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[37], [38], [39]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[58], [59], [60]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[10], [11], [12]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[65], [66], [10], [11], [12]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[13], [14], [15], [16], [17], [18]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[73], [74], [75]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[13], [17], [18]
D1020		Methenamine	C6H12N4	4101	Moderate		Inter Info	[76], [77], [78], [79], [80]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[65], [66], [10], [11], [12]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[34], [35], [36]
D0664		Flecainide	C17H20F6N2O3	3356	Minor		Inter Info	[131]
D0998		Memantine	C12H21N	4054	Minor		Inter Info	[136]
D1025		Methotrexate	C20H22N8O5	126941	Minor		Inter Info	[137], [80], [138]
Pharmacodynamic additive effects
	Increased risk of hypernatremia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[24], [92], [93]

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144	Product Information. Ticlid (ticlopidine). Syntex Laboratories Inc, Palo Alto, CA.

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