Drug General Information (ID: DDI4I6NLZ8)
Drug Name			Memantine		Drug Info		Sodium bicarbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cholinesterase Inhibitors				Antidiarrheals
Structure

Mechanism of Memantine-Sodium bicarbonate Interaction (Severity Level: Minor)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Memantine				Sodium bicarbonate
Mechanism		Urine pH sensitive				Urine alkalinizer Decrease the renal excretion
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Memantine caused by Sodium bicarbonate mediated altered urine pH

References
1	Product Information. Namenda (memantine). Forest Pharmaceuticals, St. Louis, MO.