Details of Drug-Drug Interaction
| Drug General Information (ID: DDI93UEO2K) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Duloxetine | Drug Info | Sodium bicarbonate | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antidepressants | Antidiarrheals | |||||||
| Structure | |||||||||
| Mechanism of Duloxetine-Sodium bicarbonate Interaction (Severity Level: Minor) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered gastric pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Duloxetine | Sodium bicarbonate | |||||||
| Mechanism | Gastric alkalinizer | Gastric pH sensitive | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastric pH | ||||||||
| Factor Description | The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs. | ||||||||
| Mechanism Description |
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| References | |||||||||||||||||||
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| 1 | Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN. | ||||||||||||||||||