Drug General Information (ID: DDIHUZLKMG)
Drug Name			Ofloxacin		Drug Info		Sodium bicarbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antidiarrheals
Structure

Mechanism of Ofloxacin-Sodium bicarbonate Interaction (Severity Level: Moderate)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Ofloxacin				Sodium bicarbonate
Mechanism		Urine pH sensitive				Urine alkalinizer Increase the risk of crystalluria
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Ofloxacin caused by Sodium bicarbonate mediated altered urine pH

Recommended Action
Management		Concomitant use should generally be avoided. Patients receiving this combination should be monitored for signs of renal toxicity and crystalluria.

References
1	Multum Information Services, Inc. Expert Review Panel.
2	Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.