Drug General Information (ID: DDIVKBY6NR)
  Drug Name Naproxen Drug Info Sodium bicarbonate Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Nsaids/Analgesics Antidiarrheals
  Structure

 Mechanism of Naproxen-Sodium bicarbonate Interaction (Severity Level: Minor)
     Altered gastric pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Naproxen Sodium bicarbonate
      Mechanism Gastric pH sensitive Gastric alkalinizer
      Key Mechanism Factor 1
Factor Name Gastric pH
Factor Description The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
      Mechanism Description
  • Decreased absorption of Naproxen due to altered gastric pH caused by Sodium bicarbonate 

References
1 Brogden RN, Heel RC, Speight TM, Avery GS "Naproxen up to date: a review of its pharmacological properties and therapeutic efficacy and use in rheumatic diseases and pain states." Drugs 18 (1979): 241-77. [PMID: 387372]
2 Segre EJ, Sevelius H, Varady J "Effects of antacids on naproxen absorption." N Engl J Med 291 (1974): 582-3. [PMID: 4852768]