Drug General Information (ID: DDIOIZKE4G)
Drug Name			Pancrelipase		Drug Info		Sodium bicarbonate		Drug Info
Drug Type		Protein/peptide				Small molecule
Therapeutic Class		Digestive Enzymes				Antidiarrheals
Structure

Mechanism of Pancrelipase-Sodium bicarbonate Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Pancrelipase				Sodium bicarbonate
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Pancrelipase due to altered gastric pH caused by Sodium bicarbonate

Recommended Action
Management		The administration of antacids and enteric-coated pancreatic enzyme products should be separated by at least one hour.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Multum Information Services, Inc. Expert Review Panel.