Drug General Information (ID: DDICEB7T50)
Drug Name			Cefditoren		Drug Info		Sodium bicarbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antidiarrheals
Structure

Mechanism of Cefditoren-Sodium bicarbonate Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Cefditoren				Sodium bicarbonate
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Cefditoren due to altered gastric pH caused by Sodium bicarbonate

Recommended Action
Management		The manufacturer recommends that cefditoren pivoxil not be administered concomitantly with antacids or oral medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution).

References
1	Product Information. Spectracef (cefditoren). TAP Pharmaceuticals Inc, Deerfield, IL.