Drug General Information (ID: DDIDYGAM0C)
Drug Name			Clorazepic acid		Drug Info		Sodium bicarbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Antidiarrheals
Structure

Mechanism of Clorazepic acid-Sodium bicarbonate Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Clorazepic acid				Sodium bicarbonate
Mechanism 1		Benzodiazepines				Delay absorption of benzodiazepines
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Clorazepic acid due to GI dynamics variation caused by Sodium bicarbonate
Mechanism 2		Benzodiazepine				Delay absorption of benzodiazepines
Key Mechanism Factor 2
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Clorazepic acid due to GI dynamics variation caused by Sodium bicarbonate

References
1	Greenblatt DJ, Allen MD, MacLaughlin DS, Harmatz JS, Shader RI "Diazepam absorption: effect of antacids and food." Clin Pharmacol Ther 24 (1978): 600-9. [PMID: 699484]
2	Greenblatt DJ, Shader RI, Harmatz JS, Franke K, Koch-Weser J "Absorption rate, blood concentrations, and early response to oral chlordiazepoxide." Am J Psychiatry 134 (1977): 559-62. [PMID: 848586]
3	Kroboth PD, Smith RB, Silver MR, Rault R, Sorkin MI, Puschett JB, Juhl RP "Effects of end stage renal disease and aluminium hydroxide on triazolam pharmacokinetics." Br J Clin Pharmacol 19 (1985): 839-42. [PMID: 2862896]